data stringlengths 62 36k | criteria stringlengths 174 19.2k | NCT_ID stringlengths 11 11 | metadata dict |
|---|---|---|---|
#Study Description
Brief Summary
The overall goal of this research is to develop a platform that can increase patient access to expert skin cancer diagnostic services via telemedicine. This is especially important for medically underserved areas where melanoma outcomes are worse than in areas with greater access to i... | #Eligibility Criteria:
Inclusion Criteria:
* Be 18 years or older
* Have 1 <= age <= 3 lesions for evaluation
Exclusion Criteria:
* Lesions of the hair-bearing scalp, in the mouth, on the lips, genitalia, nails, on/around the eyes, inside the ear
Sex :
ALL
Ages :
- Minimum Age : 18 Years
- Maximum Age : 90 Years
... | NCT04411810 | {
"brief_title": "SpotCheck: Comparison of Enhanced Telemedicine Versus In-person Evaluation for the Diagnosis of Skin Cancer",
"conditions": [
"Skin Cancer"
],
"interventions": [
"Device: Nevisense 3.0",
"Procedure: Skin biopsy",
"Device: Dermlite Cam",
"Device: Barco Demetra"
],
"locat... |
#Study Description
Brief Summary
The purpose of this study is to test SU011248 (sunitinib) in combination with paclitaxel/carboplatin. This combination regimen will be tested for safety and antitumor activity.
#Intervention
- DRUG : carboplatin + SU011248 (sunitinib) + paclitaxel
- AUC of 6 mg\*min/mL administere... | #Eligibility Criteria:
Inclusion Criteria:
* Histologically or cytologically proven diagnosis of any advanced solid malignancy that is not amenable to treatment with curative intent
* Candidates for treatment with carboplatin and paclitaxel with maximum of 2 prior chemotherapy regimens
* ECOG performance status 0 or 1... | NCT00511849 | {
"brief_title": "Study Of SU011248 In Combination With Paclitaxel/Carboplatin In Patients With Advanced Solid Tumors",
"conditions": [
"Neoplasms"
],
"interventions": [
"Drug: carboplatin + SU011248 (sunitinib) + paclitaxel"
],
"location_countries": [
"United States"
],
"nct_id": "NCT005118... |
#Study Description
Brief Summary
The primary objective of this study is to substantiate prediction accuracy(with a tighter 95% confidence interval compared to current diagnostic modalities), of a lung cancer biomarker for risk stratification of patients into high and low risk categories to aid in clinical evaluation ... | #Eligibility Criteria:
Inclusion Criteria:
* The patient is being evaluated for the diagnosis of possible lung cancer or 'rule out lung cancer' and is indicated for bronchoscopy.
* The patient is undergoing bronchoscopy
* >= 21 years
* Patient meets local site's standard of care (SOC) for performing diagnostic broncho... | NCT01309087 | {
"brief_title": "Airway Epithelium Gene Expression in the Diagnosis of Lung Cancer: AEGIS CLIA",
"conditions": [
"Lung Cancer"
],
"interventions": null,
"location_countries": [
"Canada",
"Ireland",
"United States"
],
"nct_id": "NCT01309087",
"official_title": "Airway Epithelium Gene Exp... |
#Study Description
Brief Summary
The aim of the present study is to evaluate an innovative virtual reality-based balance training intervention for improving clinically relevant motor performances (balance and gait) in people with mild cognitive impairment.
The investigators hypothesize that the virtual reality-based... | #Eligibility Criteria:
Inclusion Criteria:
* diagnosis of Mild Cognitive Impairment
* willingness to provide informed consent
Exclusion Criteria:
* severe neurologic, cardiovascular, metabolic, or psychiatric disorders
* severe visual impairment
* severe cognitive impairment
* dementia
Sex :
ALL
Ages :
- Age Grou... | NCT02214342 | {
"brief_title": "Virtual Reality Based Balance Training in People With Mild Cognitive Impairment",
"conditions": [
"Distorted; Balance",
"Motor Deficit",
"Cognitive Deficit"
],
"interventions": [
"Other: Balance Training"
],
"location_countries": [
"United States"
],
"nct_id": "NCT0... |
#Study Description
Brief Summary
The purpose of this study is to demonstrate safety and efficacy of SH T00660AA compared to placebo in the treatment of endometriosis
Detailed Description
The study has previously been posted by Schering AG, Germany. Schering AG, Germany has been renamed to Bayer Schering Pharma AG, ... | #Eligibility Criteria:
Inclusion Criteria:
* Female patients with endometriosis-associated pelvic pain
Exclusion Criteria:
* Pregnant or lactating women
* history or suspicion of hormone dependent tumor
* therapy resistant endometriosis
* need for primary surgical treatment
* any other conditions which forbid the pa... | NCT00225199 | {
"brief_title": "Efficacy and Safety of SH T00660AA in Treatment of Endometriosis",
"conditions": [
"Endometriosis"
],
"interventions": [
"Drug: Placebo",
"Drug: Visanne (BAY86-5258, SH T00660AA)"
],
"location_countries": null,
"nct_id": "NCT00225199",
"official_title": "A Multicenter, Doub... |
#Study Description
Brief Summary
The purpose of this study is to determine the effect of a pre-discharge written personal endorsement to the patient by the patient's attending cardiologist or cardiac surgeon (MD endorsement) to take part in the Cardiac Rehabilitation and Secondary Prevention (CR) program, in addition... | #Eligibility Criteria:
Inclusion Criteria:
* Patient is admitted to hospital for myocardial infarction (MI), unstable angina (UA), percutaneous transluminal coronary angioplasty (PTCA), or coronary artery bypass surgery (CABS)
* Patient resides within 1 hour driving time from London
Exclusion Criteria:
* Inability t... | NCT00336830 | {
"brief_title": "Improving Cardiac Rehabilitation Participation in Women and Men",
"conditions": [
"Myocardial Infarction",
"Unstable Angina",
"Coronary Disease"
],
"interventions": [
"Behavioral: Standard Cardiac Rehabilitation referral",
"Behavioral: MD-endorsed Cardiac Rehabilitation ref... |
#Study Description
Brief Summary
This is a prospective, observational study, aimed to establish the relationship between an inefficient endogenous pain modulation before surgery (total knee arthroplasty; TKA) and the probability to develop chronic pain after surgery (persistent post surgical pain). Endogenous analges... | #Eligibility Criteria:
Inclusion Criteria:
* >= 18 years patients
* Scheduled for primary total knee arthroplasty
* Disposition to visits and scheduled tests
Exclusion Criteria:
* Previous surgery on knee to be operated
* Documented peripheral neuropathy
* Severe disease or condition that could potentially interfere... | NCT01811888 | {
"brief_title": "Painful Knee Prosthesis. Relationship Between Endogenous Analgesia and Persistent Post Surgical Pain.",
"conditions": [
"Knee Osteoarthritis"
],
"interventions": [
"Behavioral: Quantitative sensory testing (QST)"
],
"location_countries": [
"Spain"
],
"nct_id": "NCT01811888"... |
#Study Description
Brief Summary
The aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits. Patients who applied to Hacettepe University Hospitals Physical Medicine and Rehabilitation D... | #Eligibility Criteria:
Inclusion Criteria for patients with disc herniation:
* Diagnosis of disc herniation (protrusion, extrusion, sequestered disc)
* not an indication for lumbar disc herniation surgery
* for patients with neurological deficits, loss of strength, decrease in DTRs, loss of sensation and at least one ... | NCT04912388 | {
"brief_title": "Serum Cytokine Levels in Patients with Lumbal Disc Herniation and Effectiveness of Exercise",
"conditions": [
"Low Back Pain"
],
"interventions": [
"Other: Lumbal stabilization excercises",
"Other: Conventional exercises"
],
"location_countries": [
"Turkey"
],
"nct_id":... |
#Study Description
Brief Summary
This is an open-label, non-randomized, phase II, single arm, multi-center controlled clinical trial.
47 patients will be enrolled in this trial to determine the efficacy and safety of Bintrafusp alfa (M7824) in advanced malignant pleural mesothelioma patients previously treated with ... | #Eligibility Criteria:
Inclusion Criteria:
* Male or female subjects aged >= 18 years and capable of giving signed informed consent or requirement per local legislation.
* ECOG performance status of 0 <= age <= 2.
* Histologically confirmed malignant pleural mesothelioma (all histological subtypes are eligible), unres... | NCT05005429 | {
"brief_title": "Study of the Efficacy and Safety of the Bintrafusp Alfa in Previously Treated Advanced Malignant Pleural Mesothelioma",
"conditions": [
"Mesothelioma; Lung"
],
"interventions": [
"Drug: Bintrafusp alfa"
],
"location_countries": [
"Spain"
],
"nct_id": "NCT05005429",
"offic... |
#Study Description
Brief Summary
In this trial the investigators will evaluate the outcomes of 4 pre-defined groups of individuals according to the therapeutic intervention. The investigators will determine the outcome of each group by monitoring the survival and the response rates of patients with FLT3-ITD AML relap... | #Eligibility Criteria:
Inclusion Criteria:
* Histology/PCR proven relapse of FLT3-ITD+ AML after allo-HSCT
* Age >=18 years
* Treatment with either chemotherapy-alone, chemotherapy/DLI, sorafenib alone or sorafenib/DLI
* Written informed consent
* Ability to understand the nature of the study and the study related pro... | NCT02867891 | {
"brief_title": "Sorafenib In Relapse of FMS-like Tyrosine Kinase 3 (FLT3)-Internal Tandem Duplication (ITD) AML Trial",
"conditions": [
"Acute Myeloid Leukemia"
],
"interventions": null,
"location_countries": null,
"nct_id": "NCT02867891",
"official_title": "Multicenter, Observational Trial to Deter... |
#Study Description
Brief Summary
The purpose of the study is to determine if an oral ketone beverage is safe and well-tolerated during moderate intensity exercise in participants with long-chain fatty acid oxidation disorders and if it will raise blood ketones to levels similar to that reported among normal healthy s... | #Eligibility Criteria:
Inclusion Criteria:
* confirmed diagnosis of VLCAD, LCHAD/TFP or CPT2 deficiency
* speak English
* willing to complete 2 moderate intensity exercise treadmills
Exclusion Criteria:
* subjects actively participating in another research study that prohibits their participation
* pregnant females
... | NCT05411835 | {
"brief_title": "Oral Ketones and Exercise Among Patients With Long-chain Fatty Acid Oxidation Disorders",
"conditions": [
"Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency",
"Carnitine Palmitoyltransferase Deficiency 2",
"Very Long Chain Acyl Coa Dehydrogenase Deficiency",
"Trifunctional Prot... |
#Study Description
Brief Summary
This is designated to validate patient-reported outcomes (PRO) measures in itch-specific pediatric skin conditions, such as atopic dermatitis, and examine the ability of a modified stigma instrument to assess the severity and type of stigma experienced in atopic dermatitis and other p... | #Eligibility Criteria:
Inclusion Criteria:
* Affected children must have moderate to severe AD or another skin condition that causes itch, experience itch, understand English, and be able to complete an English-based survey
* Any child with a potentially disfiguring skin condition or change in appearance related to di... | NCT03051347 | {
"brief_title": "Asthma and Atopic Dermatitis Validation of PROMIS Pediatric Instruments",
"conditions": [
"Atopic Dermatitis",
"Ichthyosis",
"Psoriasis"
],
"interventions": [
"Other: Itch Questionnaire and Interview",
"Other: Cognitive Interview and PROMIS Itch Questionnaire",
"Other: ... |
#Study Description
Brief Summary
The 6-month clinical study was designed to investigate clinical efficacy on plaque and gingivitis for the stannous fluoride containing toothpaste (SNAP) compared to Colgate Cavity Protection Toothpaste after 3 and 6 months of product use.
#Intervention
- DRUG : Test
- test toothpa... | #Eligibility Criteria:
Inclusion Criteria:
* Potential subjects must meet all of the following criteria
* Subjects, ages 18 <= age <= 70, inclusive
* Availability for the six-month duration of the clinical research study
* Good general health
* Initial gingivitis index of at least 1.0 as determined by the use of the L... | NCT06300866 | {
"brief_title": "Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste",
"conditions": [
"Gingivitis",
"Plaque, Dental"
],
"interventions": [
"Drug: Test",
"Drug: Control"
],
"location_countries": [
"United States"
],
"nct_id": "NCT06300866",
"official_title": "The ... |
#Study Description
Brief Summary
Type 2 Diabetes (TD2) is the leading cause of new cases of preventable blindness in these countries (and the gold-standard treatment, laser photocoagulation has proven to be effective in preventing vision loss at the end stage of eye disease due to proliferative diabetic retinopathy (... | #Eligibility Criteria:
Inclusion Criteria:
* type 2 diabetic patients
* patient with proliferative diabetic retinopathy (for arm 1)
* patient with non proliferative diabetic retinopathy (for arm 2)
* patient older than 18 years
* patient consenting to participate to the study
* patient enrolled in the national healthc... | NCT02879422 | {
"brief_title": "Genetic Markers and Proliferative Diabetic Retinopathy",
"conditions": [
"Proliferative Diabetic Retinopathy"
],
"interventions": [
"Genetic: genetic analysis"
],
"location_countries": [
"France"
],
"nct_id": "NCT02879422",
"official_title": "Study of the Association Betw... |
#Study Description
Brief Summary
Omega-3 fatty acids are provided through dietary intake of fish and seafood. Several dietary supplements containing omega-3 fatty acids are also commercially available. Some studies have described beneficial effects from omega-3 fatty acids, among them are anti-inflammatory, anti-thro... | #Eligibility Criteria:
Inclusion Criteria:
* Patients over the age of 18 who have received a kidney transplant. Patients with a functioning kidney transplant, defined as eGFR>30 ml/min. Signed informed consent.
Exclusion Criteria:
* Patients participating in clinical trials with other investigational drugs. Patients... | NCT01744067 | {
"brief_title": "The Effects of Omega-3 Fatty Acids in Renal Transplantation",
"conditions": [
"Disorder Related to Renal Transplantation"
],
"interventions": [
"Drug: Placebo",
"Drug: Omega-3 fatty acids"
],
"location_countries": [
"Norway"
],
"nct_id": "NCT01744067",
"official_title... |
#Study Description
Brief Summary
This study aims to analyze the factors influencing the abortion interval of second-trimester termination of pregnancy using misoprostol.
Detailed Description
Misoprostol is the primary drug of choice for medical termination. It is not only cheap, but also stable at room temperature ... | #Eligibility Criteria:
Inclusion Criteria:
*All female patients who were admitted for medical termination of second-trimester pregnancy
Exclusion Criteria:
* Patients who are allergy to Cytotec.
Sex :
FEMALE
Ages :
- Minimum Age : 13 Years
- Maximum Age : 50 Years
- Age Group (Child: birth-17, Adult: 18-64, Older... | NCT01927822 | {
"brief_title": "Factors Influencing the Abortion Interval of Second-trimester Termination of Pregnancy Using Misoprostol",
"conditions": [
"Labor Induction"
],
"interventions": null,
"location_countries": [
"Taiwan"
],
"nct_id": "NCT01927822",
"official_title": null,
"recruitment_information... |
#Study Description
Brief Summary
The study is to measure how dense or solid the infant's bones are using a new ultrasound machine and how that density changes over time.
Detailed Description
premature infants weighing less than 1500 gms and less than 33 weeks gestation are eligible for the study
#Intervention
- D... | #Eligibility Criteria:
Inclusion Criteria:
* premature infants born less than 33 weeks, weighing less than 1500 gms
Exclusion Criteria:
* congenital anomalies weight greater than 1500 gms
Sex :
ALL
Ages :
- Minimum Age : 24 Weeks
- Maximum Age : 33 Weeks
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65... | NCT00631397 | {
"brief_title": "A Preliminary Study of Bone Density in Neonates",
"conditions": [
"Osteopenia Of Prematurity"
],
"interventions": [
"Device: Ultrasound machine"
],
"location_countries": [
"United States"
],
"nct_id": "NCT00631397",
"official_title": "A Preliminary Study of Bone Density M... |
#Study Description
Brief Summary
The purpose of this study is to evaluate the effect of immediate versus deferred indinavir (IDV) in addition to background therapy on disease progression or death in patients with CD4+ cell counts between 200 and 500 cells/mm3 and plasma HIV RNA levels \>= 10,000 copies/ml.
This stud... | #Eligibility Criteria:
Inclusion Criteria
Concurrent Medication:
Allowed:
* Topical and/or antifungal agents, except ketoconazole.
* Treatment, maintenance, or chemoprophylaxis with approved agents for OIs will be given as clinically indicated.
* Clinically indicated antibiotics, unless excluded.
* Systemic corticos... | NCT00000861 | {
"brief_title": "The Addition of Indinavir to Anti-HIV Treatment in HIV-Infected Patients",
"conditions": [
"HIV Infections"
],
"interventions": null,
"location_countries": [
"United States"
],
"nct_id": "NCT00000861",
"official_title": "A Randomized Trial of Immediate Versus Deferred Indinavir... |
#Study Description
Brief Summary
This is retrospective research mainly aims to determine the patterns of symptoms, clinical and radiological findings and outcomes in patients with trigeminal neuropathy following trauma or iatrogenic damage and how this translates into costs for the patient and society, work disabilit... | #Eligibility Criteria:
Inclusion Criteria:
* Presentation with post traumatic, iatrogenic, injury of the trigeminal nerve or its branches (eg. inferior alveolar nerve, lingual nerve)
* Iatrogenic nerve injury caused by M3 removal, implant placement, orthognathic surgery, endodontic therapy, non-M3 removal, local anest... | NCT04612855 | {
"brief_title": "Post-traumatic Neuropathy of the Trigeminal Nerve",
"conditions": [
"Nerve Injury",
"Orofacial Pain",
"Trigeminal Nerve Injuries",
"Trigeminal Neuropathy"
],
"interventions": [
"Other: Groupwise comparison of primary and secondary outcomes"
],
"location_countries": [
... |
#Study Description
Brief Summary
This study adopted a practical approach in intermittent cooling on forehead and neck during an intra-squad baseball game. Exit velocity of batted balls was used as an indicator for hitting performance and a baseball-specific reactive agility test to evaluate the cognitive performance ... | #Eligibility Criteria:
Inclusion Criteria:
* baseball players from National Taiwan University of Sport, Taiwan
* at least 6 years of experience in baseball training
* have competed nationally.
Exclusion Criteria:
* having cardiovascular or other known chronic diseases
* taking any medication in the preceding 2 month... | NCT05068804 | {
"brief_title": "Intermittent Cooling During Baseball Games on Hitting and Defense Performance",
"conditions": [
"Decline, Cognitive"
],
"interventions": [
"Other: control",
"Procedure: Cooling"
],
"location_countries": [
"Taiwan"
],
"nct_id": "NCT05068804",
"official_title": "Intermi... |
#Study Description
Brief Summary
The purpose of this study is to see if Arimidex, an aromatase inhibitor, can delay epiphyseal fusion and increase predicted adult height in boys who are growth hormone deficient, in puberty, and who are taking growth hormone. This is a double blind, placebo controlled 3 year trial.
#... | #Eligibility Criteria:
Inclusion Criteria:
* Growth hormone deficient by formal testing with two provocative agents.
* Treated with growth hormone for a minimum of 6 months prior to study entry.
* Growth hormone doses must be maintained at 0.2 <= age <= 0.4mg/kg/wk while in protocol.
* Stable organic pathology
* Prese... | NCT00133354 | {
"brief_title": "Arimidex Multicenter Trial in Growth Hormone (GH) Deficient Boys",
"conditions": [
"Hypopituitarism"
],
"interventions": [
"Drug: Arimidex (Anastrozole)",
"Drug: Placebo",
"Drug: Growth Hormone"
],
"location_countries": [
"United States"
],
"nct_id": "NCT00133354",
... |
#Study Description
Brief Summary
This is an observational study, hence there is no study hypothesis
#Intervention
- OTHER : Patients using Wilate as standard of care
- Patients with von Willebrand Disease using Wilate for a period of 2 years. | #Eligibility Criteria:
Inclusion Criteria:
* Patients with a diagnosis of von Willebrand Disease who have been prescribed Wilate
Sex :
ALL
Ages :
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65+) : OLDER_ADULT, ADULT, CHILD
Accepts Healthy Volunteers:
No
| NCT01602419 | {
"brief_title": "Surveillance of Safety and Efficacy of Wilate in Patients With Von Willebrand Disease",
"conditions": [
"Von Willebrand Disease"
],
"interventions": [
"Other: Patients using Wilate as standard of care"
],
"location_countries": [
"Sweden",
"United States",
"Portugal",
... |
#Study Description
Brief Summary
This study is being conducted to evaluate the hypothesis that use of pharmacological and non-pharmacological interventions may allow subjects at high risk for chronic migraine to avoid or reverse the transformation of episodic migraine to chronic migraine.
Detailed Description
Two i... | #Eligibility Criteria:
Inclusion Criteria:
Subject
* Is male or female, in otherwise good health, 18 <= age <= 65 of age.
* Has history of frequent episodic migraine (6 <= age <= 14 migraine days per month) (with or without aura) according to the 2nd Edition of The International Headache Classification (ICHD-2) for a... | NCT01300546 | {
"brief_title": "Treximet Trademark (TM) in the Prevention and Modification of Disease Progression in Migraine",
"conditions": [
"Migraine"
],
"interventions": [
"Drug: Naproxen Sodium",
"Drug: Sumatriptan/Naproxen Sodium"
],
"location_countries": [
"United States"
],
"nct_id": "NCT0130... |
#Study Description
Brief Summary
Inaccuracy of laboratory medicine diagnostic tests may be associated with ingestion of over-the-counter biotin supplements.
Detailed Description
Study group 1) Due to a lack of systematic studies, little is known about how performance of specific biotinylated immunoassays is associa... | #Eligibility Criteria:
Inclusion Criteria:
* Age above 18 years
* Apparently healthy
Exclusion Criteria:
* Pre-existing condition other than hypothyroidism
* Intake of dietary supplements containing biotin
Sex :
ALL
Ages :
- Minimum Age : 18 Years
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65+) : OL... | NCT03995277 | {
"brief_title": "Effect of Biotin on Routine Laboratory Values",
"conditions": [
"Biotin Ingestion",
"Interference With Routine Analyical Tests"
],
"interventions": [
"Dietary Supplement: Biotin"
],
"location_countries": [
"Germany"
],
"nct_id": "NCT03995277",
"official_title": "Inves... |
#Study Description
Brief Summary
The main objective of this project is to evaluate the effects sought and the effects felt by children when EMONO is used in pediatric dental care. The Investigators will try to characterize the children who have submitted a request to extend contact with EMONO. The maintenance of a fr... | #Eligibility Criteria:
Inclusion Criteria:
* Children aged 3 to 15, requiring care under MEOPA
Exclusion Criteria:
* Do not fit into the inclusion criteria
Sex :
ALL
Ages :
- Minimum Age : 3 Years
- Maximum Age : 15 Years
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65+) : CHILD
Accepts Healthy Volun... | NCT03453411 | {
"brief_title": "Effects of EMONO in Children During Dental Care",
"conditions": [
"Dental Care"
],
"interventions": [
"Other: Non interventional study"
],
"location_countries": [
"France"
],
"nct_id": "NCT03453411",
"official_title": "Multicentre, Prospective, Uncontrolled Study to Descr... |
#Study Description
Brief Summary
A cross-sectional analysis of prevalence data from a stratified sample of 23 countries used to estimate the global need for palliative care for children aged 0-19 years. Prevalence data, from the Institute for Health Metrics and Evaluation, was for 12 major diagnostic groups needing c... | #Eligibility Criteria:
Inclusion Criteria:
* have one of the conditions above
Exclusion Criteria:
* greater than 19 years
Sex :
ALL
Ages :
- Maximum Age : 19 Years
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65+) : ADULT, CHILD
Accepts Healthy Volunteers:
Yes
| NCT02553148 | {
"brief_title": "Estimating the Global Need for Palliative Care for Children",
"conditions": [
"Cancer",
"Congenital Anomalies",
"Cardiovascular Disease",
"HIV"
],
"interventions": [
"Other: Need for children's palliative care"
],
"location_countries": [
"United States"
],
"nct_... |
#Study Description
Brief Summary
This randomized clinical trial studies ABH (lorazepam, diphenhydramine hydrochloride, and haloperidol) gel in patients with nausea. ABH gel, when absorbed into the skin, may be an effective treatment for nausea and vomiting. The general purpose of this research study is to improve the... | #Eligibility Criteria:
Inclusion Criteria:
* English speaking
* No allergies to the drugs
* Able to complete the forms
* If a woman of childbearing age, agree to use contraception; women will be offered a pregnancy test before doing the trial if they request one, as stated in the Informed Consent Form
* Patients must ... | NCT01556932 | {
"brief_title": "Randomized Trial of the Effectiveness of Topical 'ABH Gel' vs. Placebo in Cancer Patients With Nausea",
"conditions": [
"Nausea",
"Vomiting"
],
"interventions": [
"Drug: ABH gel",
"Other: placebo"
],
"location_countries": [
"United States"
],
"nct_id": "NCT01556932"... |
#Study Description
Brief Summary
The investigators are looking to see if a certain dose of stereotactic body radiation therapy (SBRT) may be a viable treatment option for recurrent or residual pancreatic or periampullary adenocarcinoma.
Detailed Description
No standard treatment option has yet been established for ... | #Eligibility Criteria:
Inclusion Criteria:
* 18 years or older
* Karnofsky Performance Status greater than or equal to 70%
* confirmed pancreatic or periampullary adenocarcinoma
* pancreatic or periampullary tumor less than 8.0 cm in greatest axial dimension
* Either:
* standard of care treatment for pancreatic can... | NCT01781728 | {
"brief_title": "Palliative Stereotactic Radiation for Pancreatic or Periampullary Adenocarcinoma",
"conditions": [
"Pancreatic Cancer",
"Periampullary Adenocarcinoma"
],
"interventions": [
"Radiation: Stereotactic Body Radiation Therapy (SBRT)"
],
"location_countries": [
"United States"
... |
#Study Description
Brief Summary
The purpose of this study is to compare bedside rounding with hallway and conference room rounding on the neurology inpatient ward service at an academic hospital and identify best practices associated with educational and patient care outcomes. Specifically, this study will determine... | #Eligibility Criteria:
Inclusion Criteria:
* new admission to neurology team
Exclusion Criteria:
* comfort measures as sole treatment goal
Sex :
ALL
Ages :
- Minimum Age : 18 Years
- Maximum Age : 100 Years
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65+) : OLDER_ADULT, ADULT
Accepts Healthy Volunte... | NCT04754828 | {
"brief_title": "A Study of Bedside Versus Hallway Rounding",
"conditions": [
"Education, Medical"
],
"interventions": [
"Other: Assigned to a rounding style"
],
"location_countries": [
"United States"
],
"nct_id": "NCT04754828",
"official_title": "A Study of Bedside Versus Hallway Roundi... |
#Study Description
Brief Summary
This study aimed to research the effect of different general anesthesia administration on postoperative smell functions and memory.
#Intervention
- DIAGNOSTIC_TEST : butanol threshold test and smell identification tests
- no additional intervention | #Eligibility Criteria:
Inclusion Criteria:
* American Society of Anesthesiologists (ASA) I-II risk groups
* operated under elective conditions with general anesthesia requiring intubation
* operation durations of 40 <= age <= 180 minutes.
Exclusion Criteria:
* intracranial,
* endocrine or nasal surgery,
* pregnant c... | NCT05499845 | {
"brief_title": "Effects of Different Anesthesia on Odor Memory",
"conditions": [
"Smell Functions",
"Odor Memory"
],
"interventions": [
"Diagnostic Test: butanol threshold test and smell identification tests"
],
"location_countries": [
"Turkey"
],
"nct_id": "NCT05499845",
"official_t... |
#Study Description
Brief Summary
A retrospective analysis of historical data looking at hematological remission and survival in adult relapsed / refractory B-precursor acute lymphoblastic leukemia patients.
Detailed Description
A retrospective observational study reviewing historical survival data (hematological re... | #Eligibility Criteria:
Inclusion Criteria:
* adult patients with relapsed / refractory B-precursor acute lymphoblastic leukemia
* age >= 15 years at time of de novo (initial) diagnosis of acute lymphoblastic leukemia
* initial diagnosis of acute lymphoblastic leukemia in the year 1990 or later
* No CNS involvement at ... | NCT02003612 | {
"brief_title": "Historical Data Analysis of Hematological Remission and Survival in Adults With R/R Acute Lymphoblastic Leukemia",
"conditions": [
"Acute Lymphoblastic Leukemia"
],
"interventions": [
"Other: Not applicable - observational study"
],
"location_countries": [
"France",
"United... |
#Study Description
Brief Summary
The study objective is to characterize the shift in the diversity and abundance of the skin microbial community at baseline and in response to Altreno monotherapy as compared to benzoyl peroxide (BPO) 2.5% leave-on gel monotherapy in acne patients.
Detailed Description
With the adve... | #Eligibility Criteria:
Inclusion Criteria:
* A confirmed diagnosis of acne that warrants initiating topical medications.
* Denies use of any prescribed systemic acne treatments in the past 30 days.
* Denies use of any prescribed topical medications in the past 30 days.
* Denies use of any OTC topical acne medications ... | NCT04548349 | {
"brief_title": "Profiling the Skin Microbiome in Response to Altreno in Acne Patients",
"conditions": [
"Acne",
"Healthy"
],
"interventions": [
"Drug: Altreno",
"Drug: Benzoyl peroxide"
],
"location_countries": [
"United States"
],
"nct_id": "NCT04548349",
"official_title": "Prof... |
#Study Description
Brief Summary
The study aim is to assess whether premedication with midazolam prior to surgery affects copeptin concentration in blood.
#Intervention
- DRUG : Midazolam Oral Tablet
- Midazolam Oral tablet
- OTHER : Placebo Oral Tablet
- Glucose 1000mg tablet night before surgery and 60 minute... | #Eligibility Criteria:
Inclusion Criteria:
* Patients scheduled for elective surgery
* Patients with no chronić illness and considered ASA 1 by anesthesiologist
* Patients with mild and controlled chronic illness considered ASA 2 by anesthesiologist
Exclusion Criteria:
* Patient refusal
* Chronic illness requiring i... | NCT03474939 | {
"brief_title": "The Effect of Midazolam Premedication on Copeptine Concentration in Blood",
"conditions": [
"Preanesthetic Medication",
"Copeptin"
],
"interventions": [
"Drug: Midazolam Oral Tablet",
"Other: Placebo Oral Tablet"
],
"location_countries": [
"Poland"
],
"nct_id": "NCT... |
#Study Description
Brief Summary
The study enabled assessment of changes in body mass composition, metabolic syndrome and lipid profile in patients after stroke, following rehabilitation in hospital.
Detailed Description
Stroke is estimated to affect 24-54% of the global population and is one of the leading causes ... | #Eligibility Criteria:
Inclusion criteria:
* Stroke experienced.
* Ability to stand without assistance.
* Ability to walk without aid.
* No impairments in higher mental functions
* Patient's informed, voluntary consent to participate in the study.
Exclusion criteria:
* Lack of patient's consent to participate in the... | NCT03722602 | {
"brief_title": "Body Composition of People After a Stroke",
"conditions": [
"Rehabilitation",
"Stroke",
"Body Composition"
],
"interventions": [
"Other: Standard rehabilitation after stroke"
],
"location_countries": [
"Poland"
],
"nct_id": "NCT03722602",
"official_title": "Effect... |
#Study Description
Brief Summary
A randomized 1:1 crossover trial that intends to demonstrate feasibility and safety of the Automated Insulin Delivery as Adaptive NETwork (AIDANET) system run in a new smaller network version, used in full closed loop (FCL) by adults who have been diagnosed with type 1 diabetes (T1D).... | #Eligibility Criteria:
Inclusion Criteria:
* Age >=18.0 and <=60 years at time of consent
* Clinical diagnosis, based on investigator assessment, of type 1 diabetes for at least one year
* Currently using insulin pump for at least three months; Any pump, either open loop or hybrid closed loop may be used.
* Currently ... | NCT06633965 | {
"brief_title": "Safety and Feasibility Testing of a Smaller Network Version of AIDANET",
"conditions": [
"Type 1 Diabetes"
],
"interventions": [
"Device: AIDANET"
],
"location_countries": [
"United States"
],
"nct_id": "NCT06633965",
"official_title": "Safety and Feasibility Testing of a... |
#Study Description
Brief Summary
This is a double-blind, randomized, placebo-controlled, multicenter study comprised of 3 phases:screening (up to 2 weeks \[Day -15 to Day -2\]), In-Clinic Treatment (Day -1 to Day 2; including double-blind treatment \[Day 1\]), and post-treatment follow-up (7 and 14 days after infusio... | #Eligibility Criteria:
Inclusion Criteria:
* Capable of giving and give signed informed consent
* Weigh >= 50 kg and have a body mass index >= 18 and <= 35
* Diagnosis of recurrent major depressive disorder (MDD) without psychotic features per Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V... | NCT05414422 | {
"brief_title": "A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRD",
"conditions": [
"Treatment Resistant Depression"
],
"interventions": [
"Drug: PCN-101",
"Drug: Placebo"
],
"location_countries": [
"Poland",
"Germany",
"United Sta... |
#Study Description
Brief Summary
Childhood cancer survivors are at an increased risk of cardiac toxicity due to prior anti-cancer therapy. However, adherence to cardiac screening in this population remains low. This study aims to assess the feasibility of an mHealth motivational interviewing platform called Computeri... | #Eligibility Criteria:
Inclusion Criteria:
* 18 years or older
* Diagnosed with cancer at age 17 or younger
* 2 or more years after completion of cancer therapy
* Receipt of cardiotoxic therapy (Any dose of anthracycline or 15 Gy chest radiation involving cardiac structures)
* No history of cardiomyopathy
* Have not r... | NCT05923242 | {
"brief_title": "Translating ECHOS2 Into an mHealth Platform",
"conditions": [
"Childhood Cancer",
"Cardiac Toxicity",
"Pediatric Cancer"
],
"interventions": [
"Behavioral: Computerized Intervention Authoring Software (CIAS)"
],
"location_countries": [
"United States"
],
"nct_id": "... |
#Study Description
Brief Summary
When the COVID-19 virus infects a person, it enters the lung epithelial cells of its host and uses its genetic material to replicate.
The pulmonary epithelial cells of a part of the population, known as 'secretors', are capable of expressing the antigens of the 'ABO' system on their ... | #Eligibility Criteria:
Inclusion Criteria:
* COVID19 positive patients admitted within the CHU Brugmann Hospital
Exclusion Criteria:
* None
Sex :
ALL
Ages :
- Minimum Age : 18 Years
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65+) : OLDER_ADULT, ADULT
Accepts Healthy Volunteers:
Yes
| NCT04462627 | {
"brief_title": "Reduction of COVID 19 Transmission to Health Care Professionals",
"conditions": [
"COVID 19"
],
"interventions": [
"Diagnostic Test: Blood group determination",
"Diagnostic Test: Antibody titration",
"Dietary Supplement: Probiotic"
],
"location_countries": [
"Belgium"
... |
#Study Description
Brief Summary
The purpose of this study is to evaluate the safety and efficacy of the BrainPort balance device in improving balance in people with balance deficits due to stroke.
Detailed Description
Following baseline assessments, subjects participate in 5 consecutive days (10 hours) of clinic t... | #Eligibility Criteria:
Inclusion Criteria:
* At least 18 years.
* Diagnosis of stroke for at least 6 months.
* Reached a plateau and been discharged from physical therapy.
* Able to ambulate with or without assistance.
* Ongoing balance problem.
* Able to read and understand the informed consent form, and willing to s... | NCT00567944 | {
"brief_title": "Use of the BrainPort® Balance Device to Improve Balance in Adults With Balance Deficits Due to Stroke",
"conditions": [
"Cerebrovascular Accident"
],
"interventions": null,
"location_countries": [
"United States"
],
"nct_id": "NCT00567944",
"official_title": "A Substitute Vesti... |
#Study Description
Brief Summary
Sickle cell anemia (SCA) is a serious blood disease with blood vessel changes leading to brain injury and stroke. Studies show about 11% of patients with SCA will develop obvious stroke before age 20 years, with children less than 10 years of age especially vulnerable. The main object... | #Eligibility Criteria:
Inclusion Criteria for Pre-Hydroxyurea or Pre-Transfusion Therapy Study Participants:
* The diagnosis of HbSS or HbS/ß0-thalassemia
* Age: 8.0 -- <19 years
Inclusion Criteria for Study Participants for Observation:
* The diagnosis of HbSS or HbS/ß0-thalassemia
* Age: 8.0 -- <19 years
Inclusio... | NCT01137721 | {
"brief_title": "State Of The Art Functional Imaging In Sickle Cell Disease",
"conditions": [
"Sickle Cell Anemia"
],
"interventions": null,
"location_countries": [
"United States"
],
"nct_id": "NCT01137721",
"official_title": "State Of The Art Functional Imaging In Sickle Cell Disease",
"rec... |
#Study Description
Brief Summary
A multi-center, double-blind, controlled, parallel-designed, prospective trial intended to evaluate the nutritive effects of a partially hydrolyzed cow's milk protein infant formula on infant fussiness.
Detailed Description
A multi-center, double-blind, controlled, parallel-designed... | #Eligibility Criteria:
Inclusion Criteria:
* Primary caregiver has reliable access to the internet and a reliable device (such as a computer, tablet, or smartphone) to access mobile apps and be able to view and complete study questionnaires
* Singleton birth
* 15 to 75 days of age at Visit 1, inclusive (day of birth i... | NCT05245422 | {
"brief_title": "Acceptance of a Partially Hydrolyzed Formula",
"conditions": [
"Fussy Infant (Baby)"
],
"interventions": [
"Other: Infant Formula - Intact protein",
"Other: Infant Formula - Partially hydrolyzed protein"
],
"location_countries": [
"United States"
],
"nct_id": "NCT052454... |
#Study Description
Brief Summary
Periodontitis is an inflammatory disease that causes destruction of periodontal tissues. IL-20, on the other hand, is known as a potent angiogenic, chemotactic, and pro-inflammatory cytokine associated with various chronic inflammatory disorders. IL-20 has a significant role in the re... | #Eligibility Criteria:
Inclusion Criteria:
* The following criteria were required for inclusion: being systemically healthy, not smoking, not using antibiotics or systemic corticosteroids within the previous three months, not being pregnant or nursing, not having a chronic inflammatory disease, not receiving periodont... | NCT06091800 | {
"brief_title": "Interleukin 20 and Periodontal Tisuue Destruction",
"conditions": [
"Periodontitis"
],
"interventions": [
"Other: biochemical analysis"
],
"location_countries": [
"Turkey"
],
"nct_id": "NCT06091800",
"official_title": "Determination of Levels of IL-20, TNF-α, IL1β/IL-10, ... |
#Study Description
Brief Summary
The purpose of this pilot prospective randomized control trial is to compare the initiation of labor epidural analgesia by combined spinal epidural vs. epidural for the influence on risk for postpartum depression symptoms. Investigators will randomize women to the receipt of CSE or E ... | #Eligibility Criteria:
Inclusion Criteria:
* Nulliparous (no prior childbirth)
* Singleton gestation
* Third trimester
* Healthy pregnancy
* English proficiency (surveys validated in English)
* Planned vaginal delivery
* Planning to use labor epidural analgesia
* Term delivery (>= 37.0 weeks)
Exclusion Criteria:
* S... | NCT03022526 | {
"brief_title": "CSE v. Epidural for Postpartum Depression",
"conditions": [
"Depression, Postpartum",
"Labor Pain"
],
"interventions": [
"Procedure: CSE",
"Procedure: Epidural",
"Drug: Bupivacaine / fentaNYL"
],
"location_countries": [
"United States"
],
"nct_id": "NCT03022526"... |
#Study Description
Brief Summary
AllyQuest is a novel, high impact secondary prevention intervention delivered via mobile phones to improve linkage and engagement in care among newly diagnosed HIV+ young men who have sex with men (YMSM). The features of the intervention aim to target previously identified barriers to... | #Eligibility Criteria:
Inclusion Criteria:
* HIV positive
* Diagnosed in the last 12 months
* Assigned male at birth and self identify as male
* Have had sex with another man in the last twelve months
* Own a smart phone
* Between the ages of 16 <= age <= 24
Exclusion Criteria:
* Assigned female at birth
* Non-Engli... | NCT03090958 | {
"brief_title": "AllyQuest: Engaging HIV+ YMSM in Care Through Social Networking and Gamification",
"conditions": [
"Hiv",
"HIV/AIDS"
],
"interventions": [
"Behavioral: AllyQuest"
],
"location_countries": null,
"nct_id": "NCT03090958",
"official_title": "AllyQuest: Engaging HIV+ YMSM in Car... |
#Study Description
Brief Summary
Testing comedogenicity potential of a device cream on humans.
#Intervention
- DEVICE : Lotion
- Formulated Lotion F# 13451-131 was applied on an occlusive patch and placed on a test site on each subjects back three times a week for four weeks.
- OTHER : Negative Control
- Contro... | #Eligibility Criteria:
Inclusion Criteria:
* Male or female.
* 18 <= age <= 45 old.
* Individuals that are willing to provide written informed consent and are able to read, speak, write, and understand English.
* Individuals who are acne-prone with large pores on the back, or individuals who have a history of acne vul... | NCT03428997 | {
"brief_title": "Human Comedogenicity Test",
"conditions": [
"Comedogenicity"
],
"interventions": [
"Device: Lotion",
"Other: Negative Control"
],
"location_countries": [
"United States"
],
"nct_id": "NCT03428997",
"official_title": "Human Comedogenicity Test",
"recruitment_informat... |
#Study Description
Brief Summary
Dithiolethiones, a novel class of adenosine monophosphate-activated protein kinase (AMPK) activators, prevent insulin resistance through AMPK-dependent p70 ribosomal S6 kinase-1 (S6K1) inhibition. And it is well known that the modulation of S6K1 by oltipraz inhibited the development o... | #Eligibility Criteria:
Inclusion Criteria:
* Patients over 19 under 75 years
* Patients with non-alcoholic fatty liver disease except for cirrhosis
* Patients who have abnormal ALT, AST
* Patients who are satisfied with laboratory test
* Patients who agree to contraception
* Patients who can keet the diet
Exclusion C... | NCT02068339 | {
"brief_title": "Efficacy and Safety of Oltipraz for Liver Fat Reduction in Patients With Non-Alcoholic Fatty Liver Disease Except for Liver Cirrhosis",
"conditions": [
"Non-alcholic Fatty Liver Disease"
],
"interventions": [
"Drug: Oltipraz 2 (120mg)",
"Drug: Placebo",
"Drug: Oltipraz 1 (90mg)... |
#Study Description
Brief Summary
This study is to determine whether once-per-cycle DA-3031(PEG-G-CSF) is not inferior to daily G-CSF in chemotherapy-induced neutropenia.
Detailed Description
Eligible subjects are randomly assigned to receive once-per-cycle DA-3031(PEG-G-CSF) or daily G-CSF(up to 10 days). This stud... | #Eligibility Criteria:
Inclusion Criteria:
* Age : >=18, <=70
* Diagnosis of stage II, III or IV breast cancer
* ANC>=1,500/mm3, Platelet>=100,000/mm3, ECOG : 0 or 1
* Creatinine < 1.5 x ULN
* Total bilirubin/AST/ALT < 1.5 x ULN, ALP < 2.5 x ULN
* Have given a written, informed consent
Exclusion Criteria:
* Prior ch... | NCT01674855 | {
"brief_title": "Phase III Study of DA-3031(PEG-G-CSF) in Chemotherapy-induced Neutropenia",
"conditions": [
"Chemotherapy Induced Neutropenia"
],
"interventions": [
"Drug: G-CSF",
"Drug: PEG-G-CSF"
],
"location_countries": [
"Korea, Republic of"
],
"nct_id": "NCT01674855",
"official_... |
#Study Description
Brief Summary
The study is intended to verify through clinical measurement that the NUPRO Sensodyne Prophylaxis Paste with Novamin provides immediate sensitivity relief as well as extended relief up to 28 days.
Detailed Description
It is hypothesized that the prophy paste with Novamin will give p... | #Eligibility Criteria:
Inclusion Criteria:
* Availability to complete in the 28 day duration.
* Two sensitive teeth, which are not adjacent to each other and preferably in different quadrants, which demonstrate cervical erosion, abrasion and gingival recession.
* Qualifying response to tactile stimuli as defined by a ... | NCT01669785 | {
"brief_title": "NUPRO Sensodyne Prophylaxis Paste With NovaMin Sensitivity Relief Study",
"conditions": [
"Tooth Hypersensitivity"
],
"interventions": [
"Device: Group C",
"Device: Group B",
"Device: Group A"
],
"location_countries": [
"United States"
],
"nct_id": "NCT01669785",
... |
#Study Description
Brief Summary
Stage 1 of the study is designed to provide data about the risk-benefit of 4 dose regimens of indacaterol (75, 150, 300 \& 600 µg o.d.) in order to select two doses to carry forward into study Stage 2. Study Stage 2 will provide pivotal confirmation of efficacy, safety, and tolerabili... | #Eligibility Criteria:
Inclusion Criteria:
* Male and female adults aged >= 40 years, who have signed an Informed Consent Form prior to initiation of any study-related procedure
* Co-operative outpatients with a diagnosis of COPD (moderate to severe as classified by the Global Initiative for Chronic Obstructive Pulmon... | NCT00463567 | {
"brief_title": "26 Week Efficacy, Safety and Tolerability Study of Indacaterol in Patients With Chronic Obstructive Pulmonary Disease (COPD)",
"conditions": [
"Pulmonary Disease, Chronic Obstructive",
"COPD",
"Lung Diseases, Obstructive"
],
"interventions": [
"Drug: Tiotropium (18 µg o.d.)",
... |
#Study Description
Brief Summary
The purpose of this study is to determine if a new extensively hydrolyzed formula can be consumed by children with Cow's Milk Allergy.
#Intervention
- OTHER : Experimental Extensively Hydrolyzed Formula
- OTHER : Active Comparator Formula | #Eligibility Criteria:
Inclusion Criteria:
* Good health
* Parent/guardian must be willing to provide informed consent
* Parent/guardian agrees to feed study formula provided
* Confirmation of Cow's Milk Allergy
Exclusion Criteria:
* No clinically significant abnormal findings on medical history, laboratory results,... | NCT02317952 | {
"brief_title": "Formula for Children With Cow's Milk Allergy",
"conditions": [
"Milk Allergy"
],
"interventions": [
"Other: Active Comparator Formula",
"Other: Experimental Extensively Hydrolyzed Formula"
],
"location_countries": [
"United States"
],
"nct_id": "NCT02317952",
"officia... |
#Study Description
Brief Summary
To investigate the efficacy of dydrogesterone 30 mg compared to micronized vaginal progesterone 800 mg daily for luteal phase support in hormone replacement therapy frozen embryo transfer cycles, as confirmed by visualization of fetal heart activity by pelvic ultrasound assessment of ... | #Eligibility Criteria:
Inclusion Criteria:
* <=40 years at the time of IVF/ICSI treatment
* BMI >=18 to <=30 kg/m2 with a documented history of infertility
* Have undergone COS as part of an ART treatment and have had an unsuccessful fresh embryo transfer in that cycle, OR, have undergone freeze all strategy
* Schedul... | NCT04758871 | {
"brief_title": "Oral Versus Vaginal Progesterone for Luteal Phase Supplementation in Frozen Embryo Transfer Cycles",
"conditions": [
"Frozen Embryo Transfer",
"Hormone Replacement Therapy",
"Dydrogesterone",
"Infertility, Female"
],
"interventions": [
"Drug: Micronized progesterone",
"... |
#Study Description
Brief Summary
Data and knowledge gathered on bioavailability of coffee phenolics is becoming more and more important, hence underlying the importance of better understanding the fate of these potential health promoting antioxidants. However, some analytical barriers as well as some key aspects of m... | #Eligibility Criteria:
Inclusion Criteria:
* Healthy men and women
* Aged 20 <= age <= 44 years
* Caucasian origin
* Body mass index (BMI) 19 <= age <= 25 kg/m2
* Used to drinking coffee (similar to study coffee) on a daily basis
* Being able to tolerate a 48-hour coffee abstinence
* Normal oral glucose tolerance test... | NCT01523028 | {
"brief_title": "Influence of Breakfast Consumption on Chlorogenic Acid Metabolism in Humans",
"conditions": [
"Healthy"
],
"interventions": [
"Other: Soluble Coffee"
],
"location_countries": [
"Germany"
],
"nct_id": "NCT01523028",
"official_title": null,
"recruitment_information": {
... |
#Study Description
Brief Summary
This study will evaluate Panda, a smartphone-based pain assessment tool. During a child's recovery from surgery, a Post-Anesthetic Care Unit nurse will assess their pain, which helps determine what medication they need. Traditionally, this involves asking the child to rate their pain ... | #Eligibility Criteria:
Inclusion Criteria:
* Undergoing a surgical procedure for which there is an anticipated post-surgical pain model
* Age 4 - 18 years
* ASA I-III, not requiring admission to PICU
* Written parental/guardian informed consent and subject informed assent when required (subject age >= 7 years)
Exclus... | NCT01610882 | {
"brief_title": "Panda: Evaluation of a Smartphone-based Perioperative Pain Assessment Tool",
"conditions": [
"Acute Post-operative Pain"
],
"interventions": [
"Device: Panda first followed by manual pain assessment",
"Device: Manual first followed by Panda pain assessment"
],
"location_countri... |
#Study Description
Brief Summary
This is a feasibility study using a cross-over design to implement and compare a best practice alert (BPA) with an automated in-basket message to inform providers when a patient with heart failure and reduced ejection fraction (HFrEF) is not on appropriate medical therapy. The data fr... | #Eligibility Criteria:
Inclusion Criteria:
* Cardiologist visit
* Transthoracic echocardiogram with the most recent EF >= 40%
Exclusion Criteria:
* Hypotension: SBP < 95
* Hyperkalemia: most recent K > 5.1, or any K >5.5
* Renal dysfunction: eGFR < 30
* Ventricular assist device
* Hospice care
Sex :
ALL
Ages :
- ... | NCT05077293 | {
"brief_title": "Building Electronic Tools To Enhance and Reinforce Cardiovascular Recommendations - Heart Failure",
"conditions": [
"Heart Failure",
"Heart Failure With Reduced Ejection Fraction"
],
"interventions": [
"Other: In-Basket Message",
"Other: Best Practice Alert (BPA)"
],
"locat... |
#Study Description
Brief Summary
Vancomycin is the most commonly used empiric treatment for infectious peritonitis in patients on peritoneal dialysis. Current dosing and monitoring for safety and efficacy is empiric, especially for those on rapid-cycling modalities. The goal of this study is to understand the pharmac... | #Eligibility Criteria:
Inclusion Criteria:
* Adult male or females between 18 - 85 years
* Stabilized on a PD regimen for > 3 months prior to study initiation
Exclusion Criteria:
* Clinically significant disease unrelated to renal impairment or deemed unfit by the investigator
* Allergy or hypersensitivity to vancom... | NCT03685747 | {
"brief_title": "Vancomycin Pharmacokinetics in Patients on Peritoneal Dialysis",
"conditions": [
"Peritoneal Dialysis-associated Peritonitis"
],
"interventions": [
"Drug: Vancomycin"
],
"location_countries": [
"United States"
],
"nct_id": "NCT03685747",
"official_title": "A Prospective, ... |
#Study Description
Brief Summary
The purpose of this study is to determine whether gabapentin enacarbil (XP13512/GSK1838262), hereafter referred to as GEn is effective in the treatment of neuropathic pain associated with diabetic peripheral neuropathy(DPN)
Detailed Description
This is a dose-response study of XP135... | #Eligibility Criteria:
Inclusion criteria:
* >= 18 years
* Female subjects are eligible to enter if of non-childbearing potential or not lactating, has a negative pregnancy test and agrees to use a specified highly effective method for avoiding pregnancy
* Documented medical diagnosis of Type 1 or 2 diabetes including... | NCT00643760 | {
"brief_title": "A Study In Patients With Neuropathic Pain From Diabetic Peripheral Neuropathy (DPN)",
"conditions": [
"Neuropathy, Diabetic"
],
"interventions": [
"Drug: GEn 2400mg/day",
"Drug: GEn 1200mg/day",
"Drug: Pregabalin",
"Drug: GEn 3600mg/day",
"Drug: Placebo"
],
"locatio... |
#Study Description
Brief Summary
This is a prospective, multi-site, non-randomized, data collection study. The purpose of this study is to investigate the correlation between pacing sites and ECG morphology or pacing parameters during left bundle branch pacing (LBBP) and perform the use condition analysis to assess t... | #Eligibility Criteria:
Inclusion Criteria:
* Aged from 18 <= age <= 80 old;
* Patients providing signed Informed Consent;
* Patients indicated for permanent pacing and implanted with LBBP for at least 3 months, with documentation of implantation records;
* Patients who plan to receive cardiac CT examination.
Exclusio... | NCT04119323 | {
"brief_title": "Image Location and Performance of Left Bundle Branch Pacing",
"conditions": [
"Cardiac Pacing",
"Pacing Therapy"
],
"interventions": null,
"location_countries": [
"China"
],
"nct_id": "NCT04119323",
"official_title": "Image Location and Performance of Left Bundle Branch Pac... |
#Study Description
Brief Summary
Poor diets lead to weight problems, and may increase cancer risk. Cancers may develop over a long period of time, with some possibly initiating in childhood. Therefore, promoting healthy diets and preventing excess weight gain during childhood could be cancer protective. Families infl... | #Eligibility Criteria:
Inclusion Criteria:
* African -American families with 8 <= age <= 10 year old children
* Home computer with dsl line
Exclusion Criteria:
* Parents or children who report a medically prescribed diet, identified through a pre-screening questionnaire, will be excluded because these mothers may ha... | NCT00983840 | {
"brief_title": "Family Eats:Cancer Prevention for Families",
"conditions": [
"Healthy"
],
"interventions": [
"Other: Family Eats"
],
"location_countries": [
"United States"
],
"nct_id": "NCT00983840",
"official_title": "Family Eats:Cancer Prevention for Families",
"recruitment_informat... |
#Study Description
Brief Summary
To assess the safety of a new influenza virus vaccine containing a new virus strain in healthy patients prior to the release of the vaccine.
Detailed Description
This prospective, randomized, double-blind, placebo-controlled release study will enroll approximately 300 healthy adults... | #Eligibility Criteria:
Inclusion Criteria:
* Male or female, 18 through 49 years (not yet reached their 50th birthday) at the time of investigational product administration
* Healthy by medical history and physical examination
* Written informed consent and any locally required authorization (eg, Health Insurance Port... | NCT01104493 | {
"brief_title": "A Clinical Study to Assess the Safety of a New Influenza Vaccine",
"conditions": [
"Healthy"
],
"interventions": [
"Other: Placebo",
"Biological: Monovalent Frozen FluMist®"
],
"location_countries": [
"United States"
],
"nct_id": "NCT01104493",
"official_title": "A Pr... |
#Study Description
Brief Summary
Progressively causes the breakdown of cognitive functions and impairs quality of life for patients and their caregivers. In addition to memory impairment, visual attention is also compromised, even at the stage of mild cognitive impairment due to AD (MCI-AD). No treatment has been fou... | #Eligibility Criteria:
Inclusion Criteria:
* amnestic single or multi-domain mild cognitive impairment patients in accordance with diagnostic criteria (Albert et al., 2011)
Exclusion Criteria:
* psychiatric disorders, including major depression, major vascular lesions, and other brain pathologies detected by MRI tha... | NCT03974087 | {
"brief_title": "The Effect of Transcranial Direct Current Stimulation on Visual Attention in Mild Cognitive Impairment",
"conditions": [
"Mild Cognitive Impairment"
],
"interventions": [
"Device: Transcranial Direct Current Stimulation (tDCS)"
],
"location_countries": [
"Czechia"
],
"nct_i... |
#Study Description
Brief Summary
The conventional total dose of 4 L of polyethylene glycol (PEG) given the day before the procedure is safe and effective. It has been the standard cleansing regimen for the last 25 years. To overcome the difficulty in completing the bowel preparation due to large volume and/or taste, ... | #Eligibility Criteria:
Inclusion Criteria:
* both sexes
* aged between 18 and 85 yr
* undergoing a complete colonoscopy
Exclusion Criteria:
* known or suspected gastrointestinal obstruction or perforation
* toxic megacolon
* major colonic resection
* pregnant or at risk of becoming pregnant women
* lactating women
*... | NCT01533090 | {
"brief_title": "Evaluation of Reduced-volume PEG Bowel Preparation Administered the Same Day of Colonoscopy",
"conditions": [
"Colonic Polyps",
"Cancer Colon",
"Inflammatory Bowel Disease"
],
"interventions": [
"Drug: polyethylene glycol (PEG)",
"Drug: PEG low volume with bisacodyl"
],
... |
#Study Description
Brief Summary
Current cortical EEG based depth of anaesthesia monitors do not accurately reflect the effect of opioid drugs. We have developed a new theoretically-based method of analysing the EEG. Our hypothesis is that this new method will more accurately predict depth of anaesthesia than the Bis... | #Eligibility Criteria:
Inclusion Criteria:
* Male and female patients, aged 18 <= age <= 60 years, of ASA physical status 1 <= age <= 3, presenting for elective surgery under general anaesthesia
Exclusion Criteria:
* Inadequate English comprehension due to a language barrier, cognitive deficit or intellectual disabi... | NCT00455026 | {
"brief_title": "Effect of Remifentanil on Electroencephalographic BAR Index During Propofol Anaesthesia",
"conditions": [
"Depth of Anaesthesia"
],
"interventions": [
"Drug: remifentanil"
],
"location_countries": [
"Australia"
],
"nct_id": "NCT00455026",
"official_title": "Effect of Remi... |
#Study Description
Brief Summary
This study is designed to assess the antiviral activity and safety of a two-drug regimen of CAB LA + RPV LA compared with maintenance of BIK. BIKTARVY is a registered trademark of Gilead Sciences.
#Intervention
- DRUG : Cabotegravir Tablets
- CAB tablets were available as film coa... | #Eligibility Criteria:
Inclusion Criteria:
* Participants aged >= 18 years (or >=19 where required by local regulatory agencies), at the time of signing the informed consent.
* A female participant is eligible to participate if she is not pregnant (as confirmed by a negative serum human chorionic gonadotropin (hCG) te... | NCT04542070 | {
"brief_title": "A Study to Evaluate Efficacy and Safety of Cabotegravir (CAB) Long Acting (LA) Plus (+) Rilpivirine (RPV) LA Versus BIKTARVY® (BIK) in Participants With Human Immunodeficiency Virus (HIV)-1 Who Are Virologically Suppressed",
"conditions": [
"HIV Infections"
],
"interventions": [
"Drug:... |
#Study Description
Brief Summary
This randomized, single-blinded study will investigate the effects of Spinal Manipulative Therapy on Heart Rate Variability and Pain Sensitivity in a population of patients with recurrent and persistent neck pain. Alongside, the study will also develop a clinical test for Conditioned ... | #Eligibility Criteria:
Inclusion Criteria:
* minimum 18 years,
* able to read and understand Swedish,
* persistent or recurrent Neck Pain (duration of current episode more than 6 months and at least one previous episode of NP),
* no chiropractic treatment during the previous 3 months.
Exclusion Criteria:
* condition... | NCT03576846 | {
"brief_title": "Spinal Pain and Autonomic Responses to Chiropractic Care",
"conditions": [
"Neck Pain"
],
"interventions": [
"Other: Stretching",
"Other: Stretching and Spinal manipulative therapy"
],
"location_countries": [
"Sweden"
],
"nct_id": "NCT03576846",
"official_title": "The... |
#Study Description
Brief Summary
The purpose of this study is to evaluate if anodal tDCS stimulation over M1 may decrease chronic knee OA pain in elderly subjects with defective CPM. In addition, this trial will help to investigate the role of central sensitization in knee OA and evaluate how tDCS stimulation may aff... | #Eligibility Criteria:
Inclusion Criteria:
* Individuals > 60 years, of both genders.
* Diagnosis of primary knee osteoarthritis with chronic pain self-reported.
* Be able to sign the informed consent to participate in the study.
* Chronic pain (over the past 6 months) of at least 4 on a 0 <= age <= 10 VAS scale on av... | NCT03117231 | {
"brief_title": "Effects of tDCS in Elderly With Pain Due to Knee Osteoarthritis",
"conditions": [
"Osteoarthritis, Knee",
"Chronic Pain"
],
"interventions": [
"Device: Active Transcranial Direct Current Stimulation (tDCS)",
"Device: Sham Transcranial Direct Current Stimulation (tDCS)"
],
"... |
#Study Description
Brief Summary
AIM: The aim of the present study is to investigate if Internet-delivered Mindfulness-Based Cognitive Therapy (I-MBCT) can reduce symptoms of depression and anxiety among women treated for breast cancer and men treated for prostate cancer compared to a treatment as usual control group... | #Eligibility Criteria:
Inclusion Criteria:
* Man treated for prostate cancer or woman treated for breast cancer
* Active cancer treatment must have been completed (radiation therapy, operation and chemotherapy) within the past 5 years. Ongoing endocrine therapy is all right.
* A minimum score of 3 on anxiety and/or de... | NCT03100981 | {
"brief_title": "Online Mindfulness for Women Treated for Breast Cancer and Men Treated for Prostate Cancer",
"conditions": [
"Anxiety Depression",
"Breast Cancer Female",
"Prostate Cancer"
],
"interventions": [
"Behavioral: Internet-delivered Mindfulness-Based Cognitive Therapy",
"Behavior... |
#Study Description
Brief Summary
This study aims to evaluate the effect of mandibular implant supported removable overdenture on bone height and density and compare it with implant supported fixed overdenture in single mandibular overdenture.
Detailed Description
In this study 10 patients will be selected following... | #Eligibility Criteria:
Inclusion Criteria:
* Non-smoker Patients
* Highly cooperative and motivated patients.
* Patients Systemically free from any immunosuppressive diseases.
Exclusion Criteria:
* Diabetic, hypertensive, cancer patients.
* Mandibular arch with thin knife edge, flat or flabby ridge, recent extractio... | NCT05974215 | {
"brief_title": "Peri Implant Marginal Bone Height and Bone Density",
"conditions": [
"Implant Site Reaction"
],
"interventions": [
"Device: assessment of change in bone height by cone beam computed tomography"
],
"location_countries": [
"Egypt"
],
"nct_id": "NCT05974215",
"official_title... |
#Study Description
Brief Summary
This prospective multicenter study aimed to compare the diagnostic performance of non-contrast abbreviated MRI in detecting recurrent HCC after curative treatment to that of contrast-enhanced liver CT.
Detailed Description
This study was designed as a prospective single-arm intra-in... | #Eligibility Criteria:
Inclusion Criteria:
* Age between 20-year old and 85-year old
* Patients with a history of curative treatment for HCC including surgical resection or local ablation
* No recurrence after curative treatment of HCC for more than two years
* Patient who has the plan to perform contrast-enhanced liv... | NCT05690451 | {
"brief_title": "Non-contrast Abbreviated MRI for Secondary Surveillance of HCC",
"conditions": [
"Hepatocellular Carcinoma"
],
"interventions": null,
"location_countries": [
"Korea, Republic of"
],
"nct_id": "NCT05690451",
"official_title": "The Role of Non-contrast Abbreviated MRI for Seconda... |
#Study Description
Brief Summary
To evaluate the role of high dose therapy and autologous hematopoietic cell transplant for amyloidosis.
Detailed Description
To learn about the use of high dose chemotherapy followed by transplantation using peripheral blood stem cells.
#Intervention
- PROCEDURE : high dose chemo ... | #Eligibility Criteria:
Inclusion Criteria:1. Primary amyloidosis
* Age < 75 years.
* Patients must have their pathology reviewed and the diagnosis confirmed at Stanford University Medical Center.
* Patients who have undergone bone marrow transplantation previously will not be eligible.
* Patients must have a Karnof... | NCT00186407 | {
"brief_title": "Autologous Stem Cell Rescue for Primary Amyloidosis",
"conditions": [
"Amyloidosis",
"Blood and Marrow Transplant (BMT)"
],
"interventions": null,
"location_countries": [
"United States"
],
"nct_id": "NCT00186407",
"official_title": "High Dose Chemotherapy and Autologous St... |
#Study Description
Brief Summary
This study is designed to observe muscle oxygen saturation during intense video game using gridlock training with and without upper arm compression sleeves.
Detailed Description
A competitive esport player can perform up to 500-600 mouse and keyboard actions per minute (APM) on a ty... | #Eligibility Criteria:
Inclusion Criteria:
* A ranked esport player with over 500 hours in your game
* Non-smoker
* No history of heart disease
* No history of pulmonary disease
* No history of metabolic disease including diabetes
Exclusion Criteria:
*taking any prescribed or over the counter medications that would... | NCT05037071 | {
"brief_title": "Arm Compression on Muscle Oxygen Saturation",
"conditions": [
"Muscle; Fatigue, Heart"
],
"interventions": [
"Device: Upper body graduated compression sleeve"
],
"location_countries": [
"United States"
],
"nct_id": "NCT05037071",
"official_title": "The Impact of Upper Bod... |
#Study Description
Brief Summary
Introduction: the global sugar consumption has increased in the past 50 years and their abusive intake is responsible for the insulin resistance and causes the metabolic syndrome - obesity, diabetes mellitus, hypertension and coronary heart disease. Objective: To evaluate the effect o... | #Eligibility Criteria:
Inclusion Criteria:
* dizziness related to fasting or glucose intake
* alterations of glucose tolerance test
Exclusion Criteria:
* dizziness not related to vestibular problems
* ortopedical or neurological diseases
* diabetes mellitus
Sex :
ALL
Ages :
- Minimum Age : 18 Years
- Age Group (C... | NCT02226536 | {
"brief_title": "Vestibular Dysfunction and Glucose Metabolism",
"conditions": [
"Dysfunction of Vestibular System",
"Glucose Intolerance"
],
"interventions": [
"Behavioral: fractioned diet without glucose"
],
"location_countries": null,
"nct_id": "NCT02226536",
"official_title": "Fractiona... |
#Study Description
Brief Summary
Modified ride-on toy cars (ROCs) have been viewed as one Maker Movement and become an innovative, alternative option to enhance independent mobility and socialization in young children with disabilities in the recent years. To increase the applicability of this novel intervention, thi... | #Eligibility Criteria:
Inclusion Criteria:
* 1. motor delays that resulted in motor impairments that prevented independent walking (standard deviation (SD) < -1.5, assessed by the Chinese Child Development Inventory (CCDI) via a pediatric physician) 2. can stand independently for two seconds or to tolerate standing wi... | NCT04468451 | {
"brief_title": "Does Dosage Matter: Ride-on Cars to Enhance Social-mobility Function and Motivation in Toddlers With Motor Disabilities",
"conditions": [
"Mobility Limitation"
],
"interventions": [
"Behavioral: A regular therapy program without receiving any ROC training",
"Behavioral: A 24-hour R... |
#Study Description
Brief Summary
Our study aims to clarify the impact of the use of a standard sunbed according to new EU guideline EN 60335-2-27 and possibly discount the positive effects of tanning beds. We plan to investigate the serum elevation of 25(OH)D under sunbed use, respecting the new recommendations for t... | #Eligibility Criteria:
Inclusion criteria: Probands intending to use a commercial sunbed :
* Age >= 18 years
* Regular use of commercial sunbeds
* Oral and written informed consent
Exclusion criteria: 1. Skin type I according to Fitzpatrick according to EU guideline EN 60335 <= age <= 2-27 2. Sunbed use within the la... | NCT01976481 | {
"brief_title": "Serum 25-OH Vitamin D Modulation by Sunbed Use According to EU Guideline EN 60335-2-27",
"conditions": [
"Skin Toxicity"
],
"interventions": [
"Device: sunbed exposure"
],
"location_countries": [
"Switzerland"
],
"nct_id": "NCT01976481",
"official_title": "Serum 25-OH Vit... |
#Study Description
Brief Summary
Heart failure (HF) is the leading cause of hospitalization ,rehospitalization and mortality for adults over 65 years of age.
This study aimed to assess mortality, and hospitalization rates at 30 days and one year after dicharge of patients with heart failure (HF) with reduced ejectio... | #Eligibility Criteria:
Inclusion Criteria:
* patients admitted to the ED of Monastir with a principal discharge diagnosis code for HF.
Exclusion Criteria:
* Pregnant or breast feeding women. Alteration of consciousness GCS < 15 Critically ill patients needing immediate mechanical hemodynamic of ventilatory support.
... | NCT03806972 | {
"brief_title": "Short and Long Term Prognosis of Patients Admitted to the ED With Acute Heart Failure",
"conditions": [
"Acute Heart Failure"
],
"interventions": null,
"location_countries": [
"Tunisia"
],
"nct_id": "NCT03806972",
"official_title": "Short and Long Term Prognosis of Patients Adm... |
#Study Description
Brief Summary
This is a 14-day, randomized, placebo-controlled, parallel group, masked clinical trial of oral guaifenesin for the therapy of Chronic Rhinitis (CRS) in 36 children between the ages of 7 and 18 years. The study investigates the effectiveness of guaifenesin in the relief of nasal sympt... | #Eligibility Criteria:
Inclusion Criteria:
* Children between the ages of 7 and 18 years, diagnosed with Chronic Rhinitis and nasal stuffiness for at least 3 month duration.
Exclusion Criteria:
* Children with immunodeficiency, cystic fibrosis, acute or subacute symptoms, signs of bacterial infection, and/or those w... | NCT01364467 | {
"brief_title": "The Effect of Oral Guaifenesin on Pediatric Chronic Rhinitis: A Pilot Study",
"conditions": [
"Chronic Rhinitis"
],
"interventions": [
"Drug: Guaifenesin",
"Drug: Placebo"
],
"location_countries": [
"United States"
],
"nct_id": "NCT01364467",
"official_title": "The Ef... |
#Study Description
Brief Summary
Subjects referred for a routine CTA (computed tomography angiography) or MRA (magnetic resonance angiography) will be invited to participate in the study and subjects will be involved in the study for between 2 and 12 days. Two to three visits to the study doctor will be required.
Th... | #Eligibility Criteria:
Inclusion Criteria:
* Male or female subjects, aged 18 years and older
* Any of the following:
* Known or suspected supra-aortic arterial disease based on:
* Prior stroke
* Transient ischemic attack (TIA)
* Amaurosis Fugax (transient monocular blindness)
* Referred for evaluati... | NCT01344447 | {
"brief_title": "Gadobutrol Enhanced MRA of the Supra-aortic Vessels",
"conditions": [
"Carotid Stenosis"
],
"interventions": [
"Drug: Gadobutrol (Gadovist, BAY86-4875)"
],
"location_countries": [
"France",
"Sweden",
"China",
"United States",
"Germany",
"Poland",
"Austri... |
#Study Description
Brief Summary
This study is designed to investigate the effect of a structured resistance training program on glycemic control, measured by hemoglobin A1c (glycated hemoglobin), in patients with type 2 diabetes (T2DM) who are enrolled in outpatient cardiac rehabilitation. The investigator will comp... | #Eligibility Criteria:
Inclusion Criteria:
* Diagnosis with T2DM and have been accepted for a standard outpatient cardiac rehabilitation program
* Cognitively able to comprehend the information presented in the program
* Cognitively able to give informed consent to participate in this study
Exclusion Criteria:
* Pat... | NCT02707380 | {
"brief_title": "The Effectiveness of Resistance Training on Glycemic Control for Patients With Type 2 Diabetes in Cardiac Rehabilitation",
"conditions": [
"Type 2 Diabetes (T2DM)",
"Cardiovascular Disease"
],
"interventions": [
"Other: Standard of Care",
"Other: Resistance Training"
],
"lo... |
#Study Description
Brief Summary
Agricultural biodiversity can have an important role in improving diet diversity, quality and nutrition and can be seen as the foundation of the food and nutrition value chain. Increasing the availability and access to local agricultural and/or wild biodiversity genetic resources has ... | #Eligibility Criteria:
Inclusion Criteria:
* villages: Characterized as Thai village. Only Thai villages will be selected for the study as agriculture practices, diets, food preferences, language and cultures can change drastically between ethnic groups.
* participants: i) Woman of reproductive age (between 15 <= age ... | NCT05144919 | {
"brief_title": "Biodiversity in the Diet in Vietnam",
"conditions": [
"Biodiversity",
"Food Intake",
"Nutritional Status"
],
"interventions": [
"Behavioral: Promotion of a biodiverse diet"
],
"location_countries": [
"Vietnam"
],
"nct_id": "NCT05144919",
"official_title": "The Rol... |
#Study Description
Brief Summary
Skin aging is a multifactorial process involving the 3 layers of the skin: Epidermis, dermis and hypodermis. Skin aging process involves among others: skin roughness (epidermis), skin dyschromia (epidermis, dermis), wrinkles and elastosis - skin texture changes due to collagen modific... | #Eligibility Criteria:
Inclusion Criteria:
* Healthy males and females age 30 and up
* Subjects with Fitzpatrick 4 to 9 degrees of elastosis
* Subject able to comprehend and give informed consent for participation in this study
* Subject must commit to all treatments and follow-up visits
* Subject must sign the Inform... | NCT01029301 | {
"brief_title": "Evaluation of Safety and Efficacy of Using EndyMed Pro Skin Treatment System for Skin Wrinkle Treatment on Body Areas",
"conditions": [
"Skin Aging",
"Skin Wrinkling"
],
"interventions": [
"Device: Device: EndyMed Pro System for Skin Tightening"
],
"location_countries": null,
... |
#Study Description
Brief Summary
To compare fixation with glubran2 with suture during surgery por primary inguinal hernia.
Hypothesis: Glue may induce less complications and chronic pain than suture
#Intervention
- PROCEDURE : Inguinal mesh hernioplasty | #Eligibility Criteria:
Inclusion Criteria:
* Male patients
* Aged more than 18 years
* Primary inguinal hernia
Exclusion Criteria:
* Inguinoscrotal hernia
Sex :
MALE
Ages :
- Minimum Age : 18 Years
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65+) : OLDER_ADULT, ADULT
Accepts Healthy Volunteers:
No
| NCT02197585 | {
"brief_title": "Comparison of Mesh Fixation Wit Cyanoacrylate vs Suture in Inguinal Hernia Surgery",
"conditions": [
"Chronic Pain"
],
"interventions": [
"Procedure: Inguinal mesh hernioplasty"
],
"location_countries": null,
"nct_id": "NCT02197585",
"official_title": "Cyanoacrylate vs Suture f... |
#Study Description
Brief Summary
The purpose of this study is to determine if there is an interest to optimize HF (heart failure) management in patients over 80 years old. The primary objective is to assess the effect of HF (heart failure) optimized management (guidelines of the European society of Cardiology (ESC) o... | #Eligibility Criteria:
Inclusion Criteria:
* Aged over 80 year's old subjects
* Hospitalized for an acute heart failure
* Left Ventricle Ejection Fraction <= 35%
* Evaluated life expectancy (Seattle HF score) > 1 year
Exclusion Criteria:
* Dementia
* Does not understand French language
* Followed with an optimized m... | NCT01437371 | {
"brief_title": "Is There a Benefit to Optimize Heart Failure (HF) Treatment in Aged Over 80 Year's Old Patients?",
"conditions": [
"Heart Failure"
],
"interventions": [
"Drug: - Angiotensin conversing enzyme inhibitors: enalapril, captopril, lisinopril, ramipril, trandolapril."
],
"location_countr... |
#Study Description
Brief Summary
To compare the effect of Phase 1 cardiac rehabilitation with lower limb paddling, with phase 1 cardiac rehabilitation without lower limb paddling Effects in Post Coronary artery bypass graft (CABG) Patients.
Detailed Description
Coronary artery disease (CAD) is the most common type ... | #Eligibility Criteria:
Inclusion Criteria:
* Body mass index (BMI) between 20 and 30 kg/m2
* Hemodynamic stability with or without use of positive inotropic drugs
* Absence of arrhythmias and angina
* Mean blood pressure (MBP) 60 ⩽ MBP ⩽ 100 mmHg
* Heart rate (HR) 60 ⩽ HR ⩽ 100 bpm without respiratory distress
* Respi... | NCT04556994 | {
"brief_title": "Phase 1 Cardiac Rehabilitation With and Without Lower Limb Paddling Effects in Post CABG Patients.",
"conditions": [
"Coronary Artery Disease"
],
"interventions": [
"Other: Phase 1 Cardiac Rehabilitation",
"Other: Phase 1 Cardiac Rehabilitation with Lower Limb Paddling"
],
"loc... |
#Study Description
Brief Summary
Consideration from the patient's point of view is an important step in improving postoperative functional recovery. The questionnaire Quality-of-recovery 15 (QoR-15) is a psychometrically validated questionnaire to measure the quality of postoperative functional recovery. it has been ... | #Eligibility Criteria:
Inclusion Criteria:
* Patient underage > 7 years and up to 17 years and 9 months
* Programming surgery as part of routine management
* Patient affiliated with a health insurance social
* Parental authority holders and the patient agreeing to participate in the study
Exclusion Criteria:
* Patie... | NCT04453410 | {
"brief_title": "Validation of a Pediatric Pictorial Version of the QOR-15 Postoperatory Functional Recovery Scale - QoR-15 Pédiatric",
"conditions": [
"Surgical Intervention",
"Minor"
],
"interventions": null,
"location_countries": [
"France"
],
"nct_id": "NCT04453410",
"official_title": "... |
#Study Description
Brief Summary
The aim of our study is to define the optimal ovarian stimulation protocol concerning PGD and for this reason we plan a randomized controlled trial (RCT) comparing gonadotropin-releasing hormone (GnRH) agonist protocol versus GnRH antagonist protocol. The follicle stimulating hormone ... | #Eligibility Criteria:
Inclusion Criteria:
* <= 39 years the day of oocyte retrieval
* BMI <= 29
* cycle rank 1
* menstrual cycle 25 <= age <= 36 days
* PGD or preimplantation genetic screening (PGS) requested
* ICSI
* Single embryo transfer (SET) on day 5
Exclusion Criteria:
* Polycystic Ovary Syndrome (PCOS) (acco... | NCT01888744 | {
"brief_title": "Preimplantation Genetic Diagnosis (PGD) With Gonadotropin-releasing Hormone (GnRH) Agonist Versus Antagonist",
"conditions": [
"Reproductive Endocrinology",
"Fertility",
"Optimal Stimulation Protocol"
],
"interventions": [
"Drug: GnRH agonist",
"Drug: Progesterone",
"Dr... |
#Study Description
Brief Summary
Blocking the medial antebrachial cutaneous nerve (MACN) during an axillary block often a subcutaneous wheal of local anesthetics is made what is described as painful. With the improvement of the resolution of the ultrasound machines smaller structures and nerves can be visable. In thi... | #Eligibility Criteria:
Inclusion Criteria:
* all patients scheduled for lower arm/hand surgery
Exclusion Criteria:
* patient refusal
Sex :
ALL
Ages :
- Minimum Age : 18 Years
- Age Group (Child: birth-17, Adult: 18-64, Older Adult: 65+) : OLDER_ADULT, ADULT
Accepts Healthy Volunteers:
Yes
| NCT03211949 | {
"brief_title": "Ultrasound Guided Topographic Mapping of Medial Antebrachial Cutaneous Nerve",
"conditions": [
"Nerve Block",
"Surgery",
"Anesthesia",
"Brachial Plexus Block"
],
"interventions": [
"Procedure: axillary block",
"Drug: Scandicaine"
],
"location_countries": [
"Belg... |
#Study Description
Brief Summary
Efficacy and safety of 5-Azacytidin in the treatment of the haematological relapse in patients suffering from acute myeloid leukaemia or myelodysplastic syndrome with falling CD34-chimerism after hematopoietic stem cell transplantation.
#Intervention
- DRUG : 5-Azacytidin
- in cas... | #Eligibility Criteria:
Inclusion Criteria:
Screening phase:
* Age > 18 years
* Patients with CD34+ AML or MDS post-allogeneic HSCT
* Written patient consent after consultation
Treatment phase
* AML/MDS: donor chimerism < 80% in the CD34+ subpopulation following allogeneic HSCT in patients with CD34+ AML or MDS, but... | NCT00422890 | {
"brief_title": "Treatment of Imminent Haematological Relapse in Patients With AML and MDS Following Allogeneic Stem Cell Transplantation With 5-azacitidine (Vidaza®)",
"conditions": [
"Myeloid Leukemia",
"Myelodysplastic Syndrome"
],
"interventions": null,
"location_countries": [
"Germany"
],
... |
#Study Description
Brief Summary
A robust release of endothelin-1-1 (ET) with subsequent ETA subtype receptor (ET-AR) activation occurs in patients following cardiac surgery requiring cardiopulmonary bypass (CPB). Increased ET-AR activation has been identified in patients with poor left ventricular (LV) function (red... | #Eligibility Criteria:
Inclusion Criteria:
* >60 years
* Body mass index <40 kg/m2
* Left ventricular ejection fraction less than or equal to 50% documented by a pre-operative echocardiogram
* Patients undergoing coronary artery bypass (CABG), aortic and/or mitral valve replacement or combined CABG and valve procedure... | NCT00744211 | {
"brief_title": "Proteolytic Enzyme Induction Within the Human Myocardial Interstitium",
"conditions": [
"Heart Disease"
],
"interventions": [
"Drug: 2mg/kg sitaxsentan sodium",
"Other: Vehicle",
"Drug: 1mg/kg sitaxsentan sodium"
],
"location_countries": [
"United States"
],
"nct_id... |
#Study Description
Brief Summary
In patients with Relapsing Remitting Multiple Sclerosis (RRMS), the investigators observed a positive correlation between regulatory T cell (Treg) function and vitamin D status. The present goal is to assess whether Treg function improves on supplementation with vitamin D3.
Detailed ... | #Eligibility Criteria:
Inclusion Criteria:
* Relapsing Remitting MS (Revised MCDonald criteria 2005)
* Age > 18 years
Exclusion Criteria:
* Progressive MS phenotype
* Abnormalities of vitamin D hormonal system other than low dietary intake or limited sun exposure
* Intake of drugs that influence vitamin D homeostasi... | NCT00940719 | {
"brief_title": "Vitamin D3 Supplementation and the T Cell Compartment in Multiple Sclerosis (MS)",
"conditions": [
"Multiple Sclerosis"
],
"interventions": [
"Dietary Supplement: vitamin D3"
],
"location_countries": [
"Netherlands"
],
"nct_id": "NCT00940719",
"official_title": "The Effec... |
#Study Description
Brief Summary
24 week open-labeled extension study to continue monitoring the same group of patients in the previous MRA230TW phase IIIb trial in order to evaluate the long term efficacy and safety of tocilizumab.
#Intervention
- DRUG : Tocilizumab+Methotrexate(MTX)
- Tocilizumab: 8 mg/kg every... | #Eligibility Criteria:
Inclusion Criteria:
* Patients who had completed at least 5 out of the 7 visits scheduled for weeks 2, 4, 8, 12, 16, 20 and 24 in the tocilizumab Phase IIIb study(MRA230TW).
* Patients assigned in the Phase IIIb study(MRA230TW), who had received scheduled dose for at least 16 weeks but still fai... | NCT01347983 | {
"brief_title": "Extension Study of Tocilizumab Long Term Treatment of Moderate to Severe Rheumatoid Arthritis Patients",
"conditions": [
"Rheumatoid Arthritis"
],
"interventions": null,
"location_countries": [
"Taiwan"
],
"nct_id": "NCT01347983",
"official_title": "Extension Study of Tocilizum... |
#Study Description
Brief Summary
The majority of patients presenting with shoulder pain are those with rotator cuff problems. Although telerehabilitation is a promising field in many areas, there is still limited high-quality research with strong evidence of its effectiveness for musculoskeletal problems. In this stu... | #Eligibility Criteria:
Inclusion Criteria:
* Presence of bursal facial tear 1 cm below the tear degree; presence of complaints of shoulder pain lasting for a minimum of 1 and a maximum of 6 months; having been diagnosed with partial rotator cuff tear by an orthopedist who is an expert in the field; no shoulder instabi... | NCT05904249 | {
"brief_title": "Telerehabilitation in Individuals With Rotator Cuff Tear",
"conditions": [
"Rotator Cuff Tears",
"Physiotherapy and Rehabilitation",
"Shoulder Pain",
"Rotator Cuff Injuries"
],
"interventions": [
"Other: Internet Based Synchronized Telerehabilitation",
"Other: Face-to-F... |
#Study Description
Brief Summary
This study will explore using remotely monitored 'active' non-invasive brain stimulation in children with cerebral palsy. Participants will receive active non-invasive brain stimulation with synchronous safety monitoring and guided instruction with laboratory staff after appropriate t... | #Eligibility Criteria:
Inclusion Criteria:
* Aged between 8 years 0 days and 21 years 365 days
* Children who have hemiparetic cerebral palsy with a history of perinatal brain bleed/stroke
* Receptive language function to follow two-step commands
* Able to give informed assent along with the informed consent of the le... | NCT05071586 | {
"brief_title": "Pediatric Teleneuromodulation",
"conditions": [
"Cerebral Palsy (CP)"
],
"interventions": [
"Device: Soterix 1x1 tDCS LTE Stimulator Device Model 1401"
],
"location_countries": [
"United States"
],
"nct_id": "NCT05071586",
"official_title": "Remotely Monitored Transcrania... |
#Study Description
Brief Summary
Axillary block is the good anesthetic technique for upper limb surgery without exceeding a certain total dose injected of Local Anesthetic (AL).
The maximal recommended dose of Lidocaine adrenaline in the upper limb is 500 mg. The use of ultrasound helps guiding the locoregional anes... | #Eligibility Criteria:
Inclusion Criteria:
* Patients operated for the upper limb under block axillaire
* Adult
* non-opposition
Exclusion Criteria:
* medical advice to realize axillary block
* medical advice to local anaesthetic
* Allergy
* Pregnant
* ASA 3 or more
Sex :
ALL
Ages :
- Minimum Age : 18 Years
- Age... | NCT03290404 | {
"brief_title": "Descriptive Assessment of Practice in Anaesthesia : Lidocaine 1% Adrenaline Under in Axillary Block Realization",
"conditions": [
"Axillary Block"
],
"interventions": null,
"location_countries": [
"France"
],
"nct_id": "NCT03290404",
"official_title": "Descriptive Assessment of... |
#Study Description
Brief Summary
Previous research by TARGID (KU Leuven) has demonstrated the feasibility to assess gastric content volume by means of magnetic resonance imaging (MRI) while simultaneously evaluating gastric motor function by means of an isovolumetric balloon technique. This and other research conclud... | #Eligibility Criteria:
Inclusion Criteria:
* Signed Informed Consent
* At least 18 years
* Male
* BMI between and including 18 and 30
* Understand and able to read Dutch
* In good health on the basis of medical history
Exclusion Criteria:
* Using any medication that might affect gastric function or visceral sensitiv... | NCT04847765 | {
"brief_title": "ANTERO-6 Cine-MRI Study",
"conditions": [
"Health"
],
"interventions": [
"Device: VIPUN Gastric Monitoring System prototype"
],
"location_countries": [
"Belgium"
],
"nct_id": "NCT04847765",
"official_title": "A Pilot Study to Assess the Procedural Feasibility to Combine a... |
#Study Description
Brief Summary
Kidney transplantation from living donors has been shown to carry many benefits over deceased donor transplantation. Because of benefits such as shorter waiting times and improved outcome for transplant recipients, living kidney donation accounts for an increasing number of kidney tra... | #Eligibility Criteria:
Inclusion Criteria:
* Underwent unilateral donor nephrectomy between 5 and 50 years ago; but no later than June 30, 2005 at Mayo Clinic or University of Minnesota
* Alive at the time of study recruitment
* Underwent GFR measurement before and early after donor nephrectomy (Mayo Clinic participan... | NCT01158742 | {
"brief_title": "Live Kidney Donor Study -Renal Function Study",
"conditions": [
"Kidney Donation",
"Kidney Failure",
"Kidney Transplantation"
],
"interventions": [
"Other: Glomerular Filtration Rate with Iothalamate",
"Other: Glomerular Filtration Rate with Iohexol"
],
"location_countr... |
#Study Description
Brief Summary
Tough Talks is a virtual reality based HIV disclosure intervention that allows HIV+ individuals to practice disclosing to romantic partners. Tough Talks allows participants to have the opportunity to practice disclosing using a variety of strategies and experience different outcomes i... | #Eligibility Criteria:
Inclusion Criteria:
* 16 <= age <= 29 years
* assigned male at birth
* male identified
* HIV infected
* Owns a mobile device or has access to a laptop or desktop computer
* able to understand, read, and speak English
* Reports 1 or more episodes of anal intercourse with a male partner in the las... | NCT03414372 | {
"brief_title": "Tough Talks: A Disclosure Intervention for HIV+ Young Men Who Have Sex With Men (YMSM)",
"conditions": [
"Hiv",
"HIV/AIDS",
"Disclosure"
],
"interventions": [
"Behavioral: Standard of Care",
"Behavioral: Tough Talks Clinic",
"Behavioral: Tough Talks Online"
],
"loca... |
#Study Description
Brief Summary
Glycogen Storage Disease Type II ('GSD-II'; also known as Pompe disease) is caused by a deficiency of a critical enzyme in the body called acid alpha-glucosidase (GAA). Normally, GAA is used by the body's cells to break down glycogen (a stored form of sugar) within specialized structu... | #Eligibility Criteria:
Inclusion Criteria:
* The patient or the patient's legal guardian(s) must provide written informed consent prior to any study-related procedures being performed
* The patient must have a clinical diagnosis of infantile GSD-II as defined by: (a) the patient has/had documented (in a medical record... | NCT00053573 | {
"brief_title": "rhGAA in Patients With Infantile-onset Glycogen Storage Disease-II (Pompe Disease)",
"conditions": [
"Glycogen Storage Disease Type II",
"Pompe Disease",
"Acid Maltase Deficiency Disease",
"Glycogenosis 2"
],
"interventions": [
"Biological: Myozyme"
],
"location_countri... |
#Study Description
Brief Summary
The study evaluates if fat accumulates in the pancreas in individuals at risk of developing obesity-related diabetes. It also evaluates if the amount of fat in the pancreas can predict the residual functional capacity of the pancreas (insulin secretion).
#Intervention
- OTHER : No i... | #Eligibility Criteria:
Inclusion Criteria:
* adults without prior history of pancreatic disease (other than diabetes)
Exclusion Criteria:
* use of unapproved medications
* contraindications to the MRI procedure
* contraindications to frequent blood draws
* pregnancy
* use of more than 2 alcoholic drinks/day
Sex :
A... | NCT00602953 | {
"brief_title": "Role of Pancreatic Triglyceride Content in Beta-cell Function",
"conditions": [
"Obesity",
"Type 2 Diabetes"
],
"interventions": [
"Other: No intervention planned."
],
"location_countries": [
"United States"
],
"nct_id": "NCT00602953",
"official_title": "Role of Pancr... |
#Study Description
Brief Summary
The purpose of this study is to to conduct a randomized controlled trial comparing an intervention group and a control group to evaluate the feasibility of the Promoting First Relationships method in an American Indian community through their tribal Health Promotion program, and to as... | #Eligibility Criteria:
Inclusion Criteria:
* Primary caregiver for a child aged 10 to 30 months
* Caregiver lives with the child full time for the past three months and plans to continue for at least 6 more months.
* Child is an American Indian or Alaska Native living on or near the Tribe's reservation.
* Caregiver ha... | NCT02139332 | {
"brief_title": "A Primary Prevention Trial to Strengthen Child Attachment in a Native Community",
"conditions": [
"Parent-child Interaction"
],
"interventions": [
"Behavioral: Resource & Referral Group",
"Behavioral: PFR Group"
],
"location_countries": [
"United States"
],
"nct_id": "N... |
#Study Description
Brief Summary
This is a prospective, single arm, 'roll-in' study of esmolol infusion for patients with septic shock with persistent tachycardia after adequate intravenous volume expansion. The study will evaluate the adequacy and efficiency of study protocols for the anticipated, main ECASSS study,... | #Eligibility Criteria:
Inclusion Criteria:
* Age >= 18 years
* Within 48 hours of admission to the ICU and septic shock (sepsis present at time of admission)
a. Septic shock defined by consensus criteria as i. At least two systemic inflammatory response syndrome (SIRS) criteria ii. Suspected or documented infectio... | NCT02841241 | {
"brief_title": "Esmolol Infusion for Patients With Septic Shock and Persistent Tachycardia",
"conditions": [
"Septic Shock"
],
"interventions": [
"Drug: Esmolol"
],
"location_countries": [
"United States"
],
"nct_id": "NCT02841241",
"official_title": "Esmolol to Control Adrenergic Storm ... |
#Study Description
Brief Summary
A pilot feasibility study of a small randomized controlled trial (RCT) comparing a video-conferencing cognitive behavioral coping skills (VC-CBCS) group to standard of care (SC) for symptomatic patients previously diagnosed with chronic hepatitis C to evaluate feasibility, patient sat... | #Eligibility Criteria:
Inclusion Criteria:
* Age 21 and older;
* Medically cleared by hepatology
* Patients who are currently or were previously diagnosed with chronic Hepatitis C Viral (HCV) infection;
* Evidence of ongoing symptoms, stress, or unhealthy lifestyle habits, defined as a score of greater than or equal t... | NCT04198584 | {
"brief_title": "Study of Telemedicine Stress Management and Lifestyle Group Intervention for HCV Patients",
"conditions": [
"Chronic Hepatitis C"
],
"interventions": [
"Behavioral: VC-CBCS"
],
"location_countries": [
"United States"
],
"nct_id": "NCT04198584",
"official_title": "Pilot Fe... |
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