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Jun 8

Reconstructing the Charlie Parker Omnibook using an audio-to-score automatic transcription pipeline

The Charlie Parker Omnibook is a cornerstone of jazz music education, described by pianist Ethan Iverson as "the most important jazz education text ever published". In this work we propose a new transcription pipeline and explore the extent to which state of the art music technology is able to reconstruct these scores directly from the audio without human intervention. Our pipeline includes: a newly trained source separation model for saxophone, a new MIDI transcription model for solo saxophone and an adaptation of an existing MIDI-to-score method for monophonic instruments. To assess this pipeline we also provide an enhanced dataset of Charlie Parker transcriptions as score-audio pairs with accurate MIDI alignments and downbeat annotations. This represents a challenging new benchmark for automatic audio-to-score transcription that we hope will advance research into areas beyond transcribing audio-to-MIDI alone. Together, these form another step towards producing scores that musicians can use directly, without the need for onerous corrections or revisions. To facilitate future research, all model checkpoints and data are made available to download along with code for the transcription pipeline. Improvements in our modular pipeline could one day make the automatic transcription of complex jazz solos a routine possibility, thereby enriching the resources available for music education and preservation.

  • 2 authors
·
May 26, 2024

BERT-APC: A Reference-free Framework for Automatic Pitch Correction via Musical Context Inference

Automatic Pitch Correction (APC) enhances vocal recordings by aligning pitch deviations with the intended musical notes. However, existing APC systems either rely on reference pitches, which limits their practical applicability, or employ simple pitch estimation algorithms that often fail to preserve expressiveness and naturalness. We propose BERT-APC, a novel reference-free APC framework that corrects pitch errors while maintaining the natural expressiveness of vocal performances. In BERT-APC, a novel stationary pitch predictor first estimates the perceived pitch of each note from the detuned singing voice. A context-aware note pitch predictor estimates the intended pitch sequence by leveraging a music language model repurposed to incorporate musical context. Finally, a note-level correction algorithm fixes pitch errors while preserving intentional pitch deviations for emotional expression. In addition, we introduce a learnable data augmentation strategy that improves the robustness of the music language model by simulating realistic detuning patterns. Compared to two recent singing voice transcription models, BERT-APC demonstrated superior performance in note pitch prediction, outperforming the second-best model, ROSVOT, by 10.49%p on highly detuned samples in terms of the raw pitch accuracy. In the MOS test, BERT-APC achieved the highest score of 4.32 pm 0.15, which is significantly higher than those of the widely-used commercial APC tools, AutoTune (3.22 pm 0.18) and Melodyne (3.08 pm 0.18), while maintaining a comparable ability to preserve expressive nuances. To the best of our knowledge, this is the first APC model that leverages a music language model to achieve reference-free pitch correction with symbolic musical context. The corrected audio samples of BERT-APC are available online.

Dynamics of Toxicity in Political Podcasts

Toxicity in digital media poses significant challenges, yet little attention has been given to its dynamics within the rapidly growing medium of podcasts. This paper addresses this gap by analyzing political podcast data to study the emergence and propagation of toxicity, focusing on conversation chains-structured reply patterns within podcast transcripts. Leveraging state-of-the-art transcription models and advanced conversational analysis techniques, we systematically examine toxic discourse in over 30 popular political podcasts in the United States. Our key contributions include: (1) creating a comprehensive dataset of transcribed and diarized political podcasts, identifying thousands of toxic instances using Google's Perspective API, (2) uncovering concerning trends where a majority of episodes contain at least one toxic instance, (3) introducing toxic conversation chains and analyzing their structural and linguistic properties, revealing characteristics such as longer durations, repetitive patterns, figurative language, and emotional cues tied to anger and annoyance, (4) identifying demand-related words like 'want', 'like', and 'know' as precursors to toxicity, and (5) developing predictive models to anticipate toxicity shifts based on annotated change points. Our findings provide critical insights into podcast toxicity and establish a foundation for future research on real-time monitoring and intervention mechanisms to foster healthier discourse in this influential medium.

  • 6 authors
·
Jan 21, 2025

The Effect of Spectrogram Reconstruction on Automatic Music Transcription: An Alternative Approach to Improve Transcription Accuracy

Most of the state-of-the-art automatic music transcription (AMT) models break down the main transcription task into sub-tasks such as onset prediction and offset prediction and train them with onset and offset labels. These predictions are then concatenated together and used as the input to train another model with the pitch labels to obtain the final transcription. We attempt to use only the pitch labels (together with spectrogram reconstruction loss) and explore how far this model can go without introducing supervised sub-tasks. In this paper, we do not aim at achieving state-of-the-art transcription accuracy, instead, we explore the effect that spectrogram reconstruction has on our AMT model. Our proposed model consists of two U-nets: the first U-net transcribes the spectrogram into a posteriorgram, and a second U-net transforms the posteriorgram back into a spectrogram. A reconstruction loss is applied between the original spectrogram and the reconstructed spectrogram to constrain the second U-net to focus only on reconstruction. We train our model on three different datasets: MAPS, MAESTRO, and MusicNet. Our experiments show that adding the reconstruction loss can generally improve the note-level transcription accuracy when compared to the same model without the reconstruction part. Moreover, it can also boost the frame-level precision to be higher than the state-of-the-art models. The feature maps learned by our U-net contain gridlike structures (not present in the baseline model) which implies that with the presence of the reconstruction loss, the model is probably trying to count along both the time and frequency axis, resulting in a higher note-level transcription accuracy.

  • 4 authors
·
Oct 19, 2020

VocalParse: Towards Unified and Scalable Singing Voice Transcription with Large Audio Language Models

High-quality singing annotations are fundamental to modern Singing Voice Synthesis (SVS) systems. However, obtaining these annotations at scale through manual labeling is unrealistic due to the substantial labor and musical expertise required, making automatic annotation highly necessary. Despite their utility, current automatic transcription systems face significant challenges: they often rely on complex multi-stage pipelines, struggle to recover text-note alignments, and exhibit poor generalization to out-of-distribution (OOD) singing data. To alleviate these issues, we present VocalParse, a unified singing voice transcription (SVT) model built upon a Large Audio Language Model (LALM). Specifically, our novel contribution is to introduce an interleaved prompting formulation that jointly models lyrics, melody, and word-note correspondence, yielding a generated sequence that directly maps to a structured musical score. Furthermore, we propose a Chain-of-Thought (CoT) style prompting strategy, which decodes lyrics first as a semantic scaffold, significantly mitigating the context disruption problem while preserving the structural benefits of interleaved generation. Experiments demonstrate that VocalParse achieves state-of-the-art SVT performance on multiple singing datasets. The source code and checkpoint are available at https://github.com/pymaster17/VocalParse.

  • 5 authors
·
May 5

Look before Transcription: End-to-End SlideASR with Visually-Anchored Policy Optimization

Automatic speech recognition (ASR) systems often struggle with domain-specific terminology, especially in specialized settings such as academic lectures. To address this, we define the SlideASR task, which leverages the rich visual information from presentation slides to improve transcription accuracy. Existing pipeline methods for this task tend to be complex and underperform. Although omni-modal large language models (OLLMs) provide a promising end-to-end framework, they frequently fail in practice by degenerating into simple optical character recognition (OCR) systems. To overcome this, we propose Visually-Anchored Policy Optimization (VAPO), a novel post-training method designed to control the model's reasoning process. Drawing on the Chain-of-Thought reasoning paradigm, VAPO enforces a structured "Look before Transcription" procedure using a <think><answer> format. Specifically, the model first performs OCR on the slide content within the think step, then generates the transcription by referencing this recognized visual information in the answer step. This reasoning process is optimized via reinforcement learning with four distinct rewards targeting format compliance, OCR accuracy, ASR quality, and visual anchoring consistency. To support further research, we construct SlideASR-Bench, a new entity-rich benchmark consisting of a synthetic dataset for training and testing, and a challenging real-world set for evaluation. Extensive experiments demonstrate that VAPO significantly improves recognition of domain-specific terms, establishing an effective end-to-end paradigm for SlideASR.

  • 5 authors
·
Oct 8, 2025

LiveCC: Learning Video LLM with Streaming Speech Transcription at Scale

Recent video large language models (Video LLMs) often depend on costly human annotations or proprietary model APIs (e.g., GPT-4o) to produce training data, which limits their training at scale. In this paper, we explore large-scale training for Video LLM with cheap automatic speech recognition (ASR) transcripts. Specifically, we propose a novel streaming training approach that densely interleaves the ASR words and video frames according to their timestamps. Compared to previous studies in vision-language representation with ASR, our method naturally fits the streaming characteristics of ASR, thus enabling the model to learn temporally-aligned, fine-grained vision-language modeling. To support the training algorithm, we introduce a data production pipeline to process YouTube videos and their closed captions (CC, same as ASR), resulting in Live-CC-5M dataset for pre-training and Live-WhisperX-526K dataset for high-quality supervised fine-tuning (SFT). Remarkably, even without SFT, the ASR-only pre-trained LiveCC-7B-Base model demonstrates competitive general video QA performance and exhibits a new capability in real-time video commentary. To evaluate this, we carefully design a new LiveSports-3K benchmark, using LLM-as-a-judge to measure the free-form commentary. Experiments show our final LiveCC-7B-Instruct model can surpass advanced 72B models (Qwen2.5-VL-72B-Instruct, LLaVA-Video-72B) in commentary quality even working in a real-time mode. Meanwhile, it achieves state-of-the-art results at the 7B/8B scale on popular video QA benchmarks such as VideoMME and OVOBench, demonstrating the broad generalizability of our approach. All resources of this paper have been released at https://showlab.github.io/livecc.

  • 6 authors
·
Apr 22, 2025 2

DharmaOCR: Specialized Small Language Models for Structured OCR that outperform Open-Source and Commercial Baselines

This manuscript introduces DharmaOCR Full and Lite, a pair of specialized small language models (SSLMs) for structured OCR that jointly optimize transcription quality, generation stability, and inference cost. It also presents DharmaOCR-Benchmark, a benchmark that covers printed, handwritten, and legal/administrative documents, and proposes a unified evaluation protocol that measures fidelity and structure while explicitly tracking text degeneration as a first-class benchmark metric (alongside unit cost). Beyond reporting degeneration rates, the manuscript empirically shows degeneration is not merely a quality failure, since it materially worsens production performance by increasing response time, reducing throughput, and inflating computational cost due to abnormally long generations. To the best of the author's knowledge, as a methodological contribution, this is the first application of Direct Preference Optimization (DPO) for OCR, explicitly using degenerate generations as rejected examples to penalize looping behavior. Combined with Supervised Fine-Tuning (SFT) for enforcing a strict JSON schema (header, margin, footer, and text), DPO consistently reduces degeneration rate across model families (up to 87.6% relative) while preserving or improving extraction quality. The resulting models, namely, DharmaOCR Full (7B) and DharmaOCR Lite (3B), set a new state-of-the-art on DharmaOCR-Benchmark, outperforming each open-source and commercial baseline model evaluated regarding extraction quality, reaching 0.925 and 0.911 scores with 0.40% and 0.20% degeneration rates. AWQ quantization reduced up to 22% per-page cost with negligible quality loss, enabling a strong quality-cost trade-off in comparison to proprietary OCR APIs and open-source alternatives.

  • 4 authors
·
Apr 14

GENERator: A Long-Context Generative Genomic Foundation Model

Advancements in DNA sequencing technologies have significantly improved our ability to decode genomic sequences. However, the prediction and interpretation of these sequences remain challenging due to the intricate nature of genetic material. Large language models (LLMs) have introduced new opportunities for biological sequence analysis. Recent developments in genomic language models have underscored the potential of LLMs in deciphering DNA sequences. Nonetheless, existing models often face limitations in robustness and application scope, primarily due to constraints in model structure and training data scale. To address these limitations, we present GENERator, a generative genomic foundation model featuring a context length of 98k base pairs (bp) and 1.2B parameters. Trained on an expansive dataset comprising 386B bp of eukaryotic DNA, the GENERator demonstrates state-of-the-art performance across both established and newly proposed benchmarks. The model adheres to the central dogma of molecular biology, accurately generating protein-coding sequences that translate into proteins structurally analogous to known families. It also shows significant promise in sequence optimization, particularly through the prompt-responsive generation of promoter sequences with specific activity profiles. These capabilities position the GENERator as a pivotal tool for genomic research and biotechnological advancement, enhancing our ability to interpret and predict complex biological systems and enabling precise genomic interventions.

  • 8 authors
·
Feb 11, 2025

Large Language Models are Efficient Learners of Noise-Robust Speech Recognition

Recent advances in large language models (LLMs) have promoted generative error correction (GER) for automatic speech recognition (ASR), which leverages the rich linguistic knowledge and powerful reasoning ability of LLMs to improve recognition results. The latest work proposes a GER benchmark with HyPoradise dataset to learn the mapping from ASR N-best hypotheses to ground-truth transcription by efficient LLM finetuning, which shows great effectiveness but lacks specificity on noise-robust ASR. In this work, we extend the benchmark to noisy conditions and investigate if we can teach LLMs to perform denoising for GER just like what robust ASR do}, where one solution is introducing noise information as a conditioner into LLM. However, directly incorporating noise embeddings from audio encoder could harm the LLM tuning due to cross-modality gap. To this end, we propose to extract a language-space noise embedding from the N-best list to represent the noise conditions of source speech, which can promote the denoising process in GER. Furthermore, in order to enhance its representation ability of audio noise, we design a knowledge distillation (KD) approach via mutual information estimation to distill the real noise information in audio embeddings to our language embedding. Experiments on various latest LLMs demonstrate our approach achieves a new breakthrough with up to 53.9% correction improvement in terms of word error rate while with limited training data. Analysis shows that our language-space noise embedding can well represent the noise conditions of source speech, under which off-the-shelf LLMs show strong ability of language-space denoising.

  • 7 authors
·
Jan 18, 2024

Speech-to-LaTeX: New Models and Datasets for Converting Spoken Equations and Sentences

Conversion of spoken mathematical expressions is a challenging task that involves transcribing speech into a strictly structured symbolic representation while addressing the ambiguity inherent in the pronunciation of equations. Although significant progress has been achieved in automatic speech recognition (ASR) and language models (LM), the problem of converting spoken mathematics into LaTeX remains underexplored. This task directly applies to educational and research domains, such as lecture transcription or note creation. Based on ASR post-correction, prior work requires 2 transcriptions, focuses only on isolated equations, has a limited test set, and provides neither training data nor multilingual coverage. To address these issues, we present the first fully open-source large-scale dataset, comprising over 66,000 human-annotated audio samples of mathematical equations and sentences in both English and Russian, drawn from diverse scientific domains. In addition to the ASR post-correction models and few-shot prompting, we apply audio language models, demonstrating comparable character error rate (CER) results on the MathSpeech benchmark (28% vs. 30%) for the equations conversion. In contrast, on the proposed S2L-equations benchmark, our models outperform the MathSpeech model by a substantial margin of more than 40 percentage points, even after accounting for LaTeX formatting artifacts (27% vs. 64%). We establish the first benchmark for mathematical sentence recognition (S2L-sentences) and achieve an equation CER of 40%. This work lays the groundwork for future advances in multimodal AI, with a particular focus on mathematical content recognition.

  • 9 authors
·
Aug 5, 2025 2

GigaSpeech 2: An Evolving, Large-Scale and Multi-domain ASR Corpus for Low-Resource Languages with Automated Crawling, Transcription and Refinement

The evolution of speech technology has been spurred by the rapid increase in dataset sizes. Traditional speech models generally depend on a large amount of labeled training data, which is scarce for low-resource languages. This paper presents GigaSpeech 2, a large-scale, multi-domain, multilingual speech recognition corpus. It is designed for low-resource languages and does not rely on paired speech and text data. GigaSpeech 2 comprises about 30,000 hours of automatically transcribed speech, including Thai, Indonesian, and Vietnamese, gathered from unlabeled YouTube videos. We also introduce an automated pipeline for data crawling, transcription, and label refinement. Specifically, this pipeline uses Whisper for initial transcription and TorchAudio for forced alignment, combined with multi-dimensional filtering for data quality assurance. A modified Noisy Student Training is developed to further refine flawed pseudo labels iteratively, thus enhancing model performance. Experimental results on our manually transcribed evaluation set and two public test sets from Common Voice and FLEURS confirm our corpus's high quality and broad applicability. Notably, ASR models trained on GigaSpeech 2 can reduce the word error rate for Thai, Indonesian, and Vietnamese on our challenging and realistic YouTube test set by 25% to 40% compared to the Whisper large-v3 model, with merely 10% model parameters. Furthermore, our ASR models trained on Gigaspeech 2 yield superior performance compared to commercial services. We believe that our newly introduced corpus and pipeline will open a new avenue for low-resource speech recognition and significantly facilitate research in this area.

  • 16 authors
·
Jun 17, 2024

STARS: A Unified Framework for Singing Transcription, Alignment, and Refined Style Annotation

Recent breakthroughs in singing voice synthesis (SVS) have heightened the demand for high-quality annotated datasets, yet manual annotation remains prohibitively labor-intensive and resource-intensive. Existing automatic singing annotation (ASA) methods, however, primarily tackle isolated aspects of the annotation pipeline. To address this fundamental challenge, we present STARS, which is, to our knowledge, the first unified framework that simultaneously addresses singing transcription, alignment, and refined style annotation. Our framework delivers comprehensive multi-level annotations encompassing: (1) precise phoneme-audio alignment, (2) robust note transcription and temporal localization, (3) expressive vocal technique identification, and (4) global stylistic characterization including emotion and pace. The proposed architecture employs hierarchical acoustic feature processing across frame, word, phoneme, note, and sentence levels. The novel non-autoregressive local acoustic encoders enable structured hierarchical representation learning. Experimental validation confirms the framework's superior performance across multiple evaluation dimensions compared to existing annotation approaches. Furthermore, applications in SVS training demonstrate that models utilizing STARS-annotated data achieve significantly enhanced perceptual naturalness and precise style control. This work not only overcomes critical scalability challenges in the creation of singing datasets but also pioneers new methodologies for controllable singing voice synthesis. Audio samples are available at https://gwx314.github.io/stars-demo/.

  • 9 authors
·
Jul 9, 2025

A Lightweight Instrument-Agnostic Model for Polyphonic Note Transcription and Multipitch Estimation

Automatic Music Transcription (AMT) has been recognized as a key enabling technology with a wide range of applications. Given the task's complexity, best results have typically been reported for systems focusing on specific settings, e.g. instrument-specific systems tend to yield improved results over instrument-agnostic methods. Similarly, higher accuracy can be obtained when only estimating frame-wise f_0 values and neglecting the harder note event detection. Despite their high accuracy, such specialized systems often cannot be deployed in the real-world. Storage and network constraints prohibit the use of multiple specialized models, while memory and run-time constraints limit their complexity. In this paper, we propose a lightweight neural network for musical instrument transcription, which supports polyphonic outputs and generalizes to a wide variety of instruments (including vocals). Our model is trained to jointly predict frame-wise onsets, multipitch and note activations, and we experimentally show that this multi-output structure improves the resulting frame-level note accuracy. Despite its simplicity, benchmark results show our system's note estimation to be substantially better than a comparable baseline, and its frame-level accuracy to be only marginally below those of specialized state-of-the-art AMT systems. With this work we hope to encourage the community to further investigate low-resource, instrument-agnostic AMT systems.

  • 5 authors
·
Mar 18, 2022

Preserving Privacy, Increasing Accessibility, and Reducing Cost: An On-Device Artificial Intelligence Model for Medical Transcription and Note Generation

Background: Clinical documentation represents a significant burden for healthcare providers, with physicians spending up to 2 hours daily on administrative tasks. Recent advances in large language models (LLMs) offer promising solutions, but privacy concerns and computational requirements limit their adoption in healthcare settings. Objective: To develop and evaluate a privacy-preserving, on-device medical transcription system using a fine-tuned Llama 3.2 1B model capable of generating structured medical notes from medical transcriptions while maintaining complete data sovereignty entirely in the browser. Methods: We fine-tuned a Llama 3.2 1B model using Parameter-Efficient Fine-Tuning (PEFT) with LoRA on 1,500 synthetic medical transcription-to-structured note pairs. The model was evaluated against the base Llama 3.2 1B on two datasets: 100 endocrinology transcripts and 140 modified ACI benchmark cases. Evaluation employed both statistical metrics (ROUGE, BERTScore, BLEURT) and LLM-as-judge assessments across multiple clinical quality dimensions. Results: The fine-tuned OnDevice model demonstrated substantial improvements over the base model. On the ACI benchmark, ROUGE-1 scores increased from 0.346 to 0.496, while BERTScore F1 improved from 0.832 to 0.866. Clinical quality assessments showed marked reduction in major hallucinations (from 85 to 35 cases) and enhanced factual correctness (2.81 to 3.54 on 5-point scale). Similar improvements were observed on the internal evaluation dataset, with composite scores increasing from 3.13 to 4.43 (+41.5%). Conclusions: Fine-tuning compact LLMs for medical transcription yields clinically meaningful improvements while enabling complete on-device browser deployment. This approach addresses key barriers to AI adoption in healthcare: privacy preservation, cost reduction, and accessibility for resource-constrained environments.

  • 6 authors
·
Jul 2, 2025 1

SongPrep: A Preprocessing Framework and End-to-end Model for Full-song Structure Parsing and Lyrics Transcription

Artificial Intelligence Generated Content (AIGC) is currently a popular research area. Among its various branches, song generation has attracted growing interest. Despite the abundance of available songs, effective data preparation remains a significant challenge. Converting these songs into training-ready datasets typically requires extensive manual labeling, which is both time consuming and costly. To address this issue, we propose SongPrep, an automated preprocessing pipeline designed specifically for song data. This framework streamlines key processes such as source separation, structure analysis, and lyric recognition, producing structured data that can be directly used to train song generation models. Furthermore, we introduce SongPrepE2E, an end-to-end structured lyrics recognition model based on pretrained language models. Without the need for additional source separation, SongPrepE2E is able to analyze the structure and lyrics of entire songs and provide precise timestamps. By leveraging context from the whole song alongside pretrained semantic knowledge, SongPrepE2E achieves low Diarization Error Rate (DER) and Word Error Rate (WER) on the proposed SSLD-200 dataset. Downstream tasks demonstrate that training song generation models with the data output by SongPrepE2E enables the generated songs to closely resemble those produced by humans.

  • 9 authors
·
Sep 22, 2025

XAMBA: Enabling Efficient State Space Models on Resource-Constrained Neural Processing Units

State-Space Models (SSMs) have emerged as efficient alternatives to transformers for sequential data tasks, offering linear or near-linear scalability with sequence length, making them ideal for long-sequence applications in NLP, vision, and edge AI, including real-time transcription, translation, and contextual search. These applications require lightweight, high-performance models for deployment on resource-constrained devices like laptops and PCs. Designing specialized accelerators for every emerging neural network is costly and impractical; instead, optimizing models for existing NPUs in AI PCs provides a scalable solution. To this end, we propose XAMBA, the first framework to enable and optimize SSMs on commercial off-the-shelf (COTS) state-of-the-art (SOTA) NPUs. XAMBA follows a three-step methodology: (1) enabling SSMs on NPUs, (2) optimizing performance to meet KPI requirements, and (3) trading accuracy for additional performance gains. After enabling SSMs on NPUs, XAMBA mitigates key bottlenecks using CumBA and ReduBA, replacing sequential CumSum and ReduceSum operations with matrix-based computations, significantly improving execution speed and memory efficiency. Additionally, ActiBA enhances performance by approximating expensive activation functions (e.g., Swish, Softplus) using piecewise linear mappings, reducing latency with minimal accuracy loss. Evaluations on an Intel Core Ultra Series 2 AI PC show that XAMBA achieves up to 4.8X speed-up over the baseline. Our implementation is available at https://github.com/arghadippurdue/XAMBA.

  • 6 authors
·
Feb 10, 2025

Leveraging Large Language Models for Exploiting ASR Uncertainty

While large language models excel in a variety of natural language processing (NLP) tasks, to perform well on spoken language understanding (SLU) tasks, they must either rely on off-the-shelf automatic speech recognition (ASR) systems for transcription, or be equipped with an in-built speech modality. This work focuses on the former scenario, where LLM's accuracy on SLU tasks is constrained by the accuracy of a fixed ASR system on the spoken input. Specifically, we tackle speech-intent classification task, where a high word-error-rate can limit the LLM's ability to understand the spoken intent. Instead of chasing a high accuracy by designing complex or specialized architectures regardless of deployment costs, we seek to answer how far we can go without substantially changing the underlying ASR and LLM, which can potentially be shared by multiple unrelated tasks. To this end, we propose prompting the LLM with an n-best list of ASR hypotheses instead of only the error-prone 1-best hypothesis. We explore prompt-engineering to explain the concept of n-best lists to the LLM; followed by the finetuning of Low-Rank Adapters on the downstream tasks. Our approach using n-best lists proves to be effective on a device-directed speech detection task as well as on a keyword spotting task, where systems using n-best list prompts outperform those using 1-best ASR hypothesis; thus paving the way for an efficient method to exploit ASR uncertainty via LLMs for speech-based applications.

  • 7 authors
·
Sep 9, 2023

Mel-RoFormer for Vocal Separation and Vocal Melody Transcription

Developing a versatile deep neural network to model music audio is crucial in MIR. This task is challenging due to the intricate spectral variations inherent in music signals, which convey melody, harmonics, and timbres of diverse instruments. In this paper, we introduce Mel-RoFormer, a spectrogram-based model featuring two key designs: a novel Mel-band Projection module at the front-end to enhance the model's capability to capture informative features across multiple frequency bands, and interleaved RoPE Transformers to explicitly model the frequency and time dimensions as two separate sequences. We apply Mel-RoFormer to tackle two essential MIR tasks: vocal separation and vocal melody transcription, aimed at isolating singing voices from audio mixtures and transcribing their lead melodies, respectively. Despite their shared focus on singing signals, these tasks possess distinct optimization objectives. Instead of training a unified model, we adopt a two-step approach. Initially, we train a vocal separation model, which subsequently serves as a foundation model for fine-tuning for vocal melody transcription. Through extensive experiments conducted on benchmark datasets, we showcase that our models achieve state-of-the-art performance in both vocal separation and melody transcription tasks, underscoring the efficacy and versatility of Mel-RoFormer in modeling complex music audio signals.

  • 3 authors
·
Sep 6, 2024

Aligned Music Notation and Lyrics Transcription

The digitization of vocal music scores presents unique challenges that go beyond traditional Optical Music Recognition (OMR) and Optical Character Recognition (OCR), as it necessitates preserving the critical alignment between music notation and lyrics. This alignment is essential for proper interpretation and processing in practical applications. This paper introduces and formalizes, for the first time, the Aligned Music Notation and Lyrics Transcription (AMNLT) challenge, which addresses the complete transcription of vocal scores by jointly considering music symbols, lyrics, and their synchronization. We analyze different approaches to address this challenge, ranging from traditional divide-and-conquer methods that handle music and lyrics separately, to novel end-to-end solutions including direct transcription, unfolding mechanisms, and language modeling. To evaluate these methods, we introduce four datasets of Gregorian chants, comprising both real and synthetic sources, along with custom metrics specifically designed to assess both transcription and alignment accuracy. Our experimental results demonstrate that end-to-end approaches generally outperform heuristic methods in the alignment challenge, with language models showing particular promise in scenarios where sufficient training data is available. This work establishes the first comprehensive framework for AMNLT, providing both theoretical foundations and practical solutions for preserving and digitizing vocal music heritage.

Edge-ASR: Towards Low-Bit Quantization of Automatic Speech Recognition Models

Recent advances in Automatic Speech Recognition (ASR) have demonstrated remarkable accuracy and robustness in diverse audio applications, such as live transcription and voice command processing. However, deploying these models on resource constrained edge devices (e.g., IoT device, wearables) still presents substantial challenges due to strict limits on memory, compute and power. Quantization, particularly Post-Training Quantization (PTQ), offers an effective way to reduce model size and inference cost without retraining. Despite its importance, the performance implications of various advanced quantization methods and bit-width configurations on ASR models remain unclear. In this work, we present a comprehensive benchmark of eight state-of-the-art (SOTA) PTQ methods applied to two leading edge-ASR model families, Whisper and Moonshine. We systematically evaluate model performances (i.e., accuracy, memory I/O and bit operations) across seven diverse datasets from the open ASR leaderboard, analyzing the impact of quantization and various configurations on both weights and activations. Built on an extension of the LLM compression toolkit, our framework integrates edge-ASR models, diverse advanced quantization algorithms, a unified calibration and evaluation data pipeline, and detailed analysis tools. Our results characterize the trade-offs between efficiency and accuracy, demonstrating that even 3-bit quantization can succeed on high capacity models when using advanced PTQ techniques. These findings provide valuable insights for optimizing ASR models on low-power, always-on edge devices.

  • 7 authors
·
Jul 10, 2025

HyPoradise: An Open Baseline for Generative Speech Recognition with Large Language Models

Advancements in deep neural networks have allowed automatic speech recognition (ASR) systems to attain human parity on several publicly available clean speech datasets. However, even state-of-the-art ASR systems experience performance degradation when confronted with adverse conditions, as a well-trained acoustic model is sensitive to variations in the speech domain, e.g., background noise. Intuitively, humans address this issue by relying on their linguistic knowledge: the meaning of ambiguous spoken terms is usually inferred from contextual cues thereby reducing the dependency on the auditory system. Inspired by this observation, we introduce the first open-source benchmark to utilize external large language models (LLMs) for ASR error correction, where N-best decoding hypotheses provide informative elements for true transcription prediction. This approach is a paradigm shift from the traditional language model rescoring strategy that can only select one candidate hypothesis as the output transcription. The proposed benchmark contains a novel dataset, HyPoradise (HP), encompassing more than 334,000 pairs of N-best hypotheses and corresponding accurate transcriptions across prevalent speech domains. Given this dataset, we examine three types of error correction techniques based on LLMs with varying amounts of labeled hypotheses-transcription pairs, which gains a significant word error rate (WER) reduction. Experimental evidence demonstrates the proposed technique achieves a breakthrough by surpassing the upper bound of traditional re-ranking based methods. More surprisingly, LLM with reasonable prompt and its generative capability can even correct those tokens that are missing in N-best list. We make our results publicly accessible for reproducible pipelines with released pre-trained models, thus providing a new evaluation paradigm for ASR error correction with LLMs.

  • 6 authors
·
Sep 27, 2023

JaWildText: A Benchmark for Vision-Language Models on Japanese Scene Text Understanding

Japanese scene text poses challenges that multilingual benchmarks often fail to capture, including mixed scripts, frequent vertical writing, and a character inventory far larger than the Latin alphabet. Although Japanese is included in several multilingual benchmarks, these resources do not adequately capture the language-specific complexities. Meanwhile, existing Japanese visual text datasets have primarily focused on scanned documents, leaving in-the-wild scene text underexplored. To fill this gap, we introduce JaWildText, a diagnostic benchmark for evaluating vision-language models (VLMs) on Japanese scene text understanding. JaWildText contains 3,241 instances from 2,961 images newly captured in Japan, with 1.12 million annotated characters spanning 3,643 unique character types. It comprises three complementary tasks that vary in visual organization, output format, and writing style: (i) Dense Scene Text Visual Question Answering (STVQA), which requires reasoning over multiple pieces of visual text evidence; (ii) Receipt Key Information Extraction (KIE), which tests layout-aware structured extraction from mobile-captured receipts; and (iii) Handwriting OCR, which evaluates page-level transcription across various media and writing directions. We evaluate 14 open-weight VLMs and find that the best model achieves an average score of 0.64 across the three tasks. Error analyses show recognition remains the dominant bottleneck, especially for kanji. JaWildText enables fine-grained, script-aware diagnosis of Japanese scene text capabilities, and will be released with evaluation code.

  • 2 authors
·
Mar 30

It's Never Too Late: Fusing Acoustic Information into Large Language Models for Automatic Speech Recognition

Recent studies have successfully shown that large language models (LLMs) can be successfully used for generative error correction (GER) on top of the automatic speech recognition (ASR) output. Specifically, an LLM is utilized to carry out a direct mapping from the N-best hypotheses list generated by an ASR system to the predicted output transcription. However, despite its effectiveness, GER introduces extra data uncertainty since the LLM is trained without taking into account acoustic information available in the speech signal. In this work, we aim to overcome such a limitation by infusing acoustic information before generating the predicted transcription through a novel late fusion solution termed Uncertainty-Aware Dynamic Fusion (UADF). UADF is a multimodal fusion approach implemented into an auto-regressive decoding process and works in two stages: (i) It first analyzes and calibrates the token-level LLM decision, and (ii) it then dynamically assimilates the information from the acoustic modality. Experimental evidence collected from various ASR tasks shows that UADF surpasses existing fusion mechanisms in several ways. It yields significant improvements in word error rate (WER) while mitigating data uncertainty issues in LLM and addressing the poor generalization relied with sole modality during fusion. We also demonstrate that UADF seamlessly adapts to audio-visual speech recognition.

  • 7 authors
·
Feb 8, 2024

SpeakerLM: End-to-End Versatile Speaker Diarization and Recognition with Multimodal Large Language Models

The Speaker Diarization and Recognition (SDR) task aims to predict "who spoke when and what" within an audio clip, which is a crucial task in various real-world multi-speaker scenarios such as meeting transcription and dialogue systems. Existing SDR systems typically adopt a cascaded framework, combining multiple modules such as speaker diarization (SD) and automatic speech recognition (ASR). The cascaded systems suffer from several limitations, such as error propagation, difficulty in handling overlapping speech, and lack of joint optimization for exploring the synergy between SD and ASR tasks. To address these limitations, we introduce SpeakerLM, a unified multimodal large language model for SDR that jointly performs SD and ASR in an end-to-end manner. Moreover, to facilitate diverse real-world scenarios, we incorporate a flexible speaker registration mechanism into SpeakerLM, enabling SDR under different speaker registration settings. SpeakerLM is progressively developed with a multi-stage training strategy on large-scale real data. Extensive experiments show that SpeakerLM demonstrates strong data scaling capability and generalizability, outperforming state-of-the-art cascaded baselines on both in-domain and out-of-domain public SDR benchmarks. Furthermore, experimental results show that the proposed speaker registration mechanism effectively ensures robust SDR performance of SpeakerLM across diverse speaker registration conditions and varying numbers of registered speakers.

  • 9 authors
·
Aug 8, 2025

Transducing Language Models

Modern language models define distributions over strings, but downstream tasks often require different output formats. For instance, a model that generates byte-pair strings does not directly produce word-level predictions, and a DNA model does not directly produce amino-acid sequences. In such cases, a deterministic string-to-string transformation can convert the model's output to the desired form. This is a familiar pattern in probability theory: applying a function f to a random variable Xsim p yields a transformed random variable f(X) with an induced distribution. While such transformations are occasionally used in language modeling, prior work does not treat them as yielding new, fully functional language models. We formalize this perspective and introduce a general framework for language models derived from deterministic string-to-string transformations. We focus on transformations representable as finite-state transducers -- a commonly used state-machine abstraction for efficient string-to-string mappings. We develop algorithms that compose a language model with an FST to *marginalize* over source strings mapping to a given target, propagating probabilities through the transducer without altering model parameters and enabling *conditioning* on transformed outputs. We present an exact algorithm, an efficient approximation, and a theoretical analysis. We conduct experiments in three domains: converting language models from tokens to bytes, from tokens to words, and from DNA to amino acids. These experiments demonstrate inference-time adaptation of pretrained language models to match application-specific output requirements.

  • 6 authors
·
Mar 4

BMFM-DNA: A SNP-aware DNA foundation model to capture variant effects

Large language models (LLMs) trained on text demonstrated remarkable results on natural language processing (NLP) tasks. These models have been adapted to decipher the language of DNA, where sequences of nucleotides act as "words" that encode genomic functions. However, the genome differs fundamentally from natural language, as it lacks clearly defined words or a consistent grammar. Although DNA language models (DNALMs) such as DNABERT, GENA-LM have achieved high level of performance on genome-related biological tasks, these models do not encode biological functions in the presence of sequence variations. To address this problem, we pre-train foundation models that effectively integrate sequence variations, in particular Single Nucleotide Polymorphisms (SNPs), as they underlie important biological functions. Specifically, we use ModernBERT to pre-train two different Biomedical Foundation Models (BMFM), namely, BMFM-DNA-REF in which the model is trained with sequences of varying lengths along with their reverse complements derived from the reference genome and BMFM-DNA-SNP in which the model is trained with sequences created using a novel representation scheme that encodes sequence variations. Our findings indicate that integrating sequence variations into DNALMs helps capture the biological functions as seen in improvements on all fine-tuning tasks. To explore the model's practical utility, we experimented with various strategies for SNP imputation on promoter detection task introduced in DNABERT-2. However, we acknowledge that the current benchmarks are limited in their ability to fully evaluate these models. To enable more comprehensive assessment in the future and encourage community contributions, we release our models through HuggingFace and the code to reproduce the results at https://github.com/BiomedSciAI/biomed-multi-omic

ibm-research IBM Research
·
Jun 26, 2025

Does your model understand genes? A benchmark of gene properties for biological and text models

The application of deep learning methods, particularly foundation models, in biological research has surged in recent years. These models can be text-based or trained on underlying biological data, especially omics data of various types. However, comparing the performance of these models consistently has proven to be a challenge due to differences in training data and downstream tasks. To tackle this problem, we developed an architecture-agnostic benchmarking approach that, instead of evaluating the models directly, leverages entity representation vectors from each model and trains simple predictive models for each benchmarking task. This ensures that all types of models are evaluated using the same input and output types. Here we focus on gene properties collected from professionally curated bioinformatics databases. These gene properties are categorized into five major groups: genomic properties, regulatory functions, localization, biological processes, and protein properties. Overall, we define hundreds of tasks based on these databases, which include binary, multi-label, and multi-class classification tasks. We apply these benchmark tasks to evaluate expression-based models, large language models, protein language models, DNA-based models, and traditional baselines. Our findings suggest that text-based models and protein language models generally outperform expression-based models in genomic properties and regulatory functions tasks, whereas expression-based models demonstrate superior performance in localization tasks. These results should aid in the development of more informed artificial intelligence strategies for biological understanding and therapeutic discovery. To ensure the reproducibility and transparency of our findings, we have made the source code and benchmark data publicly accessible for further investigation and expansion at github.com/BiomedSciAI/gene-benchmark.

  • 5 authors
·
Dec 5, 2024

BEACON: Benchmark for Comprehensive RNA Tasks and Language Models

RNA plays a pivotal role in translating genetic instructions into functional outcomes, underscoring its importance in biological processes and disease mechanisms. Despite the emergence of numerous deep learning approaches for RNA, particularly universal RNA language models, there remains a significant lack of standardized benchmarks to assess the effectiveness of these methods. In this study, we introduce the first comprehensive RNA benchmark BEACON (BEnchmArk for COmprehensive RNA Task and Language Models). First, BEACON comprises 13 distinct tasks derived from extensive previous work covering structural analysis, functional studies, and engineering applications, enabling a comprehensive assessment of the performance of methods on various RNA understanding tasks. Second, we examine a range of models, including traditional approaches like CNNs, as well as advanced RNA foundation models based on language models, offering valuable insights into the task-specific performances of these models. Third, we investigate the vital RNA language model components from the tokenizer and positional encoding aspects. Notably, our findings emphasize the superiority of single nucleotide tokenization and the effectiveness of Attention with Linear Biases (ALiBi) over traditional positional encoding methods. Based on these insights, a simple yet strong baseline called BEACON-B is proposed, which can achieve outstanding performance with limited data and computational resources. The datasets and source code of our benchmark are available at https://github.com/terry-r123/RNABenchmark.

  • 13 authors
·
Jun 14, 2024

When De-noising Hurts: A Systematic Study of Speech Enhancement Effects on Modern Medical ASR Systems

Speech enhancement methods are commonly believed to improve the performance of automatic speech recognition (ASR) in noisy environments. However, the effectiveness of these techniques cannot be taken for granted in the case of modern large-scale ASR models trained on diverse, noisy data. We present a systematic evaluation of MetricGAN-plus-voicebank denoising on four state-of-the-art ASR systems: OpenAI Whisper, NVIDIA Parakeet, Google Gemini Flash 2.0, Parrotlet-a using 500 medical speech recordings under nine noise conditions. ASR performance is measured using semantic WER (semWER), a normalized word error rate (WER) metric accounting for domain-specific normalizations. Our results reveal a counterintuitive finding: speech enhancement preprocessing degrades ASR performance across all noise conditions and models. Original noisy audio achieves lower semWER than enhanced audio in all 40 tested configurations (4 models x 10 conditions), with degradations ranging from 1.1% to 46.6% absolute semWER increase. These findings suggest that modern ASR models possess sufficient internal noise robustness and that traditional speech enhancement may remove acoustic features critical for ASR. For practitioners deploying medical scribe systems in noisy clinical environments, our results indicate that preprocessing audio with noise reduction techniques might not just be computationally wasteful but also be potentially harmful to the transcription accuracy.

  • 11 authors
·
Dec 19, 2025

StressTest: Can YOUR Speech LM Handle the Stress?

Sentence stress refers to emphasis, placed on specific words within a spoken utterance to highlight or contrast an idea, or to introduce new information. It is often used to imply an underlying intention that is not explicitly stated. Recent advances in speech-aware language models (SLMs) have enabled direct processing of audio, allowing models to bypass transcription and access the full richness of the speech signal and perform audio reasoning tasks such as spoken question answering. Despite the crucial role of sentence stress in shaping meaning and speaker intent, it remains largely overlooked in evaluation and development of such models. In this work, we address this gap by introducing StressTest, a benchmark specifically designed to evaluate a model's ability to distinguish between interpretations of spoken sentences based on the stress pattern. We assess the performance of several leading SLMs and find that, despite their overall capabilities, they perform poorly on such tasks. To overcome this limitation, we propose a novel synthetic data generation pipeline, and create Stress17k, a training set that simulates change of meaning implied by stress variation. Then, we empirically show that optimizing models with this synthetic dataset aligns well with real-world recordings and enables effective finetuning of SLMs. Results suggest, that our finetuned model, StresSLM, significantly outperforms existing models on both sentence stress reasoning and detection tasks. Code, models, data, and audio samples - pages.cs.huji.ac.il/adiyoss-lab/stresstest.

  • 3 authors
·
May 28, 2025 2

CarelessWhisper: Turning Whisper into a Causal Streaming Model

Automatic Speech Recognition (ASR) has seen remarkable progress, with models like OpenAI Whisper and NVIDIA Canary achieving state-of-the-art (SOTA) performance in offline transcription. However, these models are not designed for streaming (online or real-time) transcription, due to limitations in their architecture and training methodology. We propose a method to turn the transformer encoder-decoder model into a low-latency streaming model that is careless about future context. We present an analysis explaining why it is not straightforward to convert an encoder-decoder transformer to a low-latency streaming model. Our proposed method modifies the existing (non-causal) encoder to a causal encoder by fine-tuning both the encoder and decoder using Low-Rank Adaptation (LoRA) and a weakly aligned dataset. We then propose an updated inference mechanism that utilizes the fine-tune causal encoder and decoder to yield greedy and beam-search decoding, and is shown to be locally optimal. Experiments on low-latency chunk sizes (less than 300 msec) show that our fine-tuned model outperforms existing non-fine-tuned streaming approaches in most cases, while using a lower complexity. Additionally, we observe that our training process yields better alignment, enabling a simple method for extracting word-level timestamps. We release our training and inference code, along with the fine-tuned models, to support further research and development in streaming ASR.

  • 3 authors
·
Aug 17, 2025

Fleurs-SLU: A Massively Multilingual Benchmark for Spoken Language Understanding

While recent multilingual automatic speech recognition models claim to support thousands of languages, ASR for low-resource languages remains highly unreliable due to limited bimodal speech and text training data. Better multilingual spoken language understanding (SLU) can strengthen massively the robustness of multilingual ASR by levering language semantics to compensate for scarce training data, such as disambiguating utterances via context or exploiting semantic similarities across languages. Even more so, SLU is indispensable for inclusive speech technology in roughly half of all living languages that lack a formal writing system. However, the evaluation of multilingual SLU remains limited to shallower tasks such as intent classification or language identification. To address this, we present Fleurs-SLU, a multilingual SLU benchmark that encompasses topical speech classification in 102 languages and multiple-choice question answering through listening comprehension in 92 languages. We extensively evaluate both end-to-end speech classification models and cascaded systems that combine speech-to-text transcription with subsequent classification by large language models on Fleurs-SLU. Our results show that cascaded systems exhibit greater robustness in multilingual SLU tasks, though speech encoders can achieve competitive performance in topical speech classification when appropriately pre-trained. We further find a strong correlation between robust multilingual ASR, effective speech-to-text translation, and strong multilingual SLU, highlighting the mutual benefits between acoustic and semantic speech representations.

  • 4 authors
·
Jan 10, 2025

SpeechTaxi: On Multilingual Semantic Speech Classification

Recent advancements in multilingual speech encoding as well as transcription raise the question of the most effective approach to semantic speech classification. Concretely, can (1) end-to-end (E2E) classifiers obtained by fine-tuning state-of-the-art multilingual speech encoders (MSEs) match or surpass the performance of (2) cascading (CA), where speech is first transcribed into text and classification is delegated to a text-based classifier. To answer this, we first construct SpeechTaxi, an 80-hour multilingual dataset for semantic speech classification of Bible verses, covering 28 diverse languages. We then leverage SpeechTaxi to conduct a wide range of experiments comparing E2E and CA in monolingual semantic speech classification as well as in cross-lingual transfer. We find that E2E based on MSEs outperforms CA in monolingual setups, i.e., when trained on in-language data. However, MSEs seem to have poor cross-lingual transfer abilities, with E2E substantially lagging CA both in (1) zero-shot transfer to languages unseen in training and (2) multilingual training, i.e., joint training on multiple languages. Finally, we devise a novel CA approach based on transcription to Romanized text as a language-agnostic intermediate representation and show that it represents a robust solution for languages without native ASR support. Our SpeechTaxi dataset is publicly available at: https://huggingface.co/ datasets/LennartKeller/SpeechTaxi/.

  • 2 authors
·
Sep 10, 2024

Whistle: Data-Efficient Multilingual and Crosslingual Speech Recognition via Weakly Phonetic Supervision

There exist three approaches for multilingual and crosslingual automatic speech recognition (MCL-ASR) - supervised pretraining with phonetic or graphemic transcription, and self-supervised pretraining. We find that pretraining with phonetic supervision has been underappreciated so far for MCL-ASR, while conceptually it is more advantageous for information sharing between different languages. This paper explores the approach of pretraining with weakly phonetic supervision towards data-efficient MCL-ASR, which is called Whistle. We relax the requirement of gold-standard human-validated phonetic transcripts, and obtain International Phonetic Alphabet (IPA) based transcription by leveraging the LanguageNet grapheme-to-phoneme (G2P) models. We construct a common experimental setup based on the CommonVoice dataset, called CV-Lang10, with 10 seen languages and 2 unseen languages. A set of experiments are conducted on CV-Lang10 to compare, as fair as possible, the three approaches under the common setup for MCL-ASR. Experiments demonstrate the advantages of phoneme-based models (Whistle) for MCL-ASR, in terms of speech recognition for seen languages, crosslingual performance for unseen languages with different amounts of few-shot data, overcoming catastrophic forgetting, and training efficiency. It is found that when training data is more limited, phoneme supervision can achieve better results compared to subword supervision and self-supervision, thereby providing higher data-efficiency. To support reproducibility and promote future research along this direction, we release the code, models and data for the entire pipeline of Whistle at https://github.com/thu-spmi/CAT/tree/master/egs/cv-lang10.

  • 5 authors
·
Jun 4, 2024

NucEL: Single-Nucleotide ELECTRA-Style Genomic Pre-training for Efficient and Interpretable Representations

Pre-training large language models on genomic sequences is a powerful approach for learning biologically meaningful representations. Masked language modeling (MLM) methods, such as DNABERT and Nucleotide Transformer (NT), achieve strong performance but suffer from partial token supervision, pre-training/fine-tuning mismatches, and high computational costs. We introduce NucEL, the first ELECTRA-style pre-training framework for genomic foundation models, addressing these limitations. Using a discriminator to identify tokens altered by a generator, NucEL provides comprehensive token-level supervision across all sequence positions, improving efficiency over the partial supervision of MLM. Incorporating ModernBERT's hybrid local-global attention and flash attention, NucEL offers an optimized BERT architecture for genomic modeling. Unlike 6-mer tokenization, NucEL uses single-nucleotide tokens for fine-grained resolution, boosting both efficiency and interpretability. Pre-trained on the human genome, NucEL achieves state-of-the-art results on diverse downstream tasks -- regulatory element identification (e.g., promoters, enhancers), transcription factor binding prediction, open chromatin classification, and histone modification profiling -- surpassing similarly sized MLM-based models and rivaling models 25x larger, such as NT. Ablation studies highlight optimal tokenization and masking strategies for ELECTRA-style DNA pre-training. Attention analysis reveals NucEL's superior capture of biologically relevant motifs compared to NT, providing insights into hierarchical learning and regulatory element modeling. These findings demonstrate ELECTRA-style pre-training as an efficient, effective strategy for genomic representation learning with broad implications for genomic research.

  • 3 authors
·
Aug 14, 2025

Find Central Dogma Again

In recent years, large language models (LLMs) have achieved state-of-the-art results in various biological sequence analysis tasks, such as sequence classification, structure prediction, and function prediction. Similar to advancements in AI for other scientific fields, deeper research into biological LLMs has begun to focus on using these models to rediscover important existing biological laws or uncover entirely new patterns in biological sequences.This study leverages GPT-like LLMs to utilize language transfer capabilities to rediscover the genetic code rules of the central dogma. In our experimental design, we transformed the central dogma into a binary classification problem of aligning DNA sequences with protein sequences, where positive examples are matching DNA and protein sequences, and negative examples are non-matching pairs.We first trained a GPT-2 model from scratch using a dataset comprising protein sequences, DNA sequences, and sequences from languages such as English and Chinese. Subsequently, we fine-tuned the model using the English similarity judgment dataset from PAWS-X. When tested on a dataset for DNA and protein sequence alignment judgment, the fine-tuned model achieved a classification accuracy of 76%. The study also analyzed factors contributing to this zero-shot capability, including model training stability and types of training data.This research demonstrates that LLMs can, through the transfer of natural language capabilities and solely relying on the analysis of sequences themselves, rediscover the central dogma without prior knowledge of it. This study opens a new door for AI-driven biological research.

  • 1 authors
·
Feb 10, 2025

BMFM-RNA: An Open Framework for Building and Evaluating Transcriptomic Foundation Models

Transcriptomic foundation models (TFMs) have recently emerged as powerful tools for analyzing gene expression in cells and tissues, supporting key tasks such as cell-type annotation, batch correction, and perturbation prediction. However, the diversity of model implementations and training strategies across recent TFMs, though promising, makes it challenging to isolate the contribution of individual design choices or evaluate their potential synergies. This hinders the field's ability to converge on best practices and limits the reproducibility of insights across studies. We present BMFM-RNA, an open-source, modular software package that unifies diverse TFM pretraining and fine-tuning objectives within a single framework. Leveraging this capability, we introduce a novel training objective, whole cell expression decoder (WCED), which captures global expression patterns using an autoencoder-like CLS bottleneck representation. In this paper, we describe the framework, supported input representations, and training objectives. We evaluated four model checkpoints pretrained on CELLxGENE using combinations of masked language modeling (MLM), WCED and multitask learning. Using the benchmarking capabilities of BMFM-RNA, we show that WCED-based models achieve performance that matches or exceeds state-of-the-art approaches like scGPT across more than a dozen datasets in both zero-shot and fine-tuning tasks. BMFM-RNA, available as part of the biomed-multi-omics project ( https://github.com/BiomedSciAI/biomed-multi-omic ), offers a reproducible foundation for systematic benchmarking and community-driven exploration of optimal TFM training strategies, enabling the development of more effective tools to leverage the latest advances in AI for understanding cell biology.

ibm-research IBM Research
·
Jun 17, 2025

Bio-xLSTM: Generative modeling, representation and in-context learning of biological and chemical sequences

Language models for biological and chemical sequences enable crucial applications such as drug discovery, protein engineering, and precision medicine. Currently, these language models are predominantly based on Transformer architectures. While Transformers have yielded impressive results, their quadratic runtime dependency on the sequence length complicates their use for long genomic sequences and in-context learning on proteins and chemical sequences. Recently, the recurrent xLSTM architecture has been shown to perform favorably compared to Transformers and modern state-space model (SSM) architectures in the natural language domain. Similar to SSMs, xLSTMs have a linear runtime dependency on the sequence length and allow for constant-memory decoding at inference time, which makes them prime candidates for modeling long-range dependencies in biological and chemical sequences. In this work, we tailor xLSTM towards these domains and propose a suite of architectural variants called Bio-xLSTM. Extensive experiments in three large domains, genomics, proteins, and chemistry, were performed to assess xLSTM's ability to model biological and chemical sequences. The results show that models based on Bio-xLSTM a) can serve as proficient generative models for DNA, protein, and chemical sequences, b) learn rich representations for those modalities, and c) can perform in-context learning for proteins and small molecules.

  • 10 authors
·
Nov 6, 2024

DART-Eval: A Comprehensive DNA Language Model Evaluation Benchmark on Regulatory DNA

Recent advances in self-supervised models for natural language, vision, and protein sequences have inspired the development of large genomic DNA language models (DNALMs). These models aim to learn generalizable representations of diverse DNA elements, potentially enabling various genomic prediction, interpretation and design tasks. Despite their potential, existing benchmarks do not adequately assess the capabilities of DNALMs on key downstream applications involving an important class of non-coding DNA elements critical for regulating gene activity. In this study, we introduce DART-Eval, a suite of representative benchmarks specifically focused on regulatory DNA to evaluate model performance across zero-shot, probed, and fine-tuned scenarios against contemporary ab initio models as baselines. Our benchmarks target biologically meaningful downstream tasks such as functional sequence feature discovery, predicting cell-type specific regulatory activity, and counterfactual prediction of the impacts of genetic variants. We find that current DNALMs exhibit inconsistent performance and do not offer compelling gains over alternative baseline models for most tasks, while requiring significantly more computational resources. We discuss potentially promising modeling, data curation, and evaluation strategies for the next generation of DNALMs. Our code is available at https://github.com/kundajelab/DART-Eval.

  • 6 authors
·
Dec 6, 2024

An Interdisciplinary Comparison of Sequence Modeling Methods for Next-Element Prediction

Data of sequential nature arise in many application domains in forms of, e.g. textual data, DNA sequences, and software execution traces. Different research disciplines have developed methods to learn sequence models from such datasets: (i) in the machine learning field methods such as (hidden) Markov models and recurrent neural networks have been developed and successfully applied to a wide-range of tasks, (ii) in process mining process discovery techniques aim to generate human-interpretable descriptive models, and (iii) in the grammar inference field the focus is on finding descriptive models in the form of formal grammars. Despite their different focuses, these fields share a common goal - learning a model that accurately describes the behavior in the underlying data. Those sequence models are generative, i.e, they can predict what elements are likely to occur after a given unfinished sequence. So far, these fields have developed mainly in isolation from each other and no comparison exists. This paper presents an interdisciplinary experimental evaluation that compares sequence modeling techniques on the task of next-element prediction on four real-life sequence datasets. The results indicate that machine learning techniques that generally have no aim at interpretability in terms of accuracy outperform techniques from the process mining and grammar inference fields that aim to yield interpretable models.

  • 3 authors
·
Oct 31, 2018

Lost in Tokenization: Context as the Key to Unlocking Biomolecular Understanding in Scientific LLMs

Scientific Large Language Models (Sci-LLMs) have emerged as a promising frontier for accelerating biological discovery. However, these models face a fundamental challenge when processing raw biomolecular sequences: the tokenization dilemma. Whether treating sequences as a specialized language, risking the loss of functional motif information, or as a separate modality, introducing formidable alignment challenges, current strategies fundamentally limit their reasoning capacity. We challenge this sequence-centric paradigm by positing that a more effective strategy is to provide Sci-LLMs with high-level structured context derived from established bioinformatics tools, thereby bypassing the need to interpret low-level noisy sequence data directly. Through a systematic comparison of leading Sci-LLMs on biological reasoning tasks, we tested three input modes: sequence-only, context-only, and a combination of both. Our findings are striking: the context-only approach consistently and substantially outperforms all other modes. Even more revealing, the inclusion of the raw sequence alongside its high-level context consistently degrades performance, indicating that raw sequences act as informational noise, even for models with specialized tokenization schemes. These results suggest that the primary strength of existing Sci-LLMs lies not in their nascent ability to interpret biomolecular syntax from scratch, but in their profound capacity for reasoning over structured, human-readable knowledge. Therefore, we argue for reframing Sci-LLMs not as sequence decoders, but as powerful reasoning engines over expert knowledge. This work lays the foundation for a new class of hybrid scientific AI agents, repositioning the developmental focus from direct sequence interpretation towards high-level knowledge synthesis. The code is available at https://github.com/opendatalab-raiser/CoKE.

  • 13 authors
·
Oct 27, 2025