id stringlengths 24 24 | type stringclasses 4
values | body stringlengths 13 215 | ideal_answer listlengths 1 12 | exact_answer listlengths 0 44 | snippets listlengths 0 121 | documents listlengths 1 157 | triples listlengths 0 537 | concepts listlengths 0 99 |
|---|---|---|---|---|---|---|---|---|
58850ac7e56acf5176000012 | yesno | Is there a role of proton beam therapy in medulloblastoma treatment? | [
"Yes, proton beam therapy is used for treatment of medulloblastoma."
] | [
"yes"
] | [
"All papers directly compared outcomes from protons with photons, five papers included medulloblastoma, four papers each included craniopharyngioma and low grade gliomas and three papers included ependymoma.",
"There are many indications of protontherapy for paediatric brain tumours in curative intent, either for... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16165914",
"http://www.ncbi.nlm.nih.gov/pubmed/9231669",
"http://www.ncbi.nlm.nih.gov/pubmed/25415685",
"http://www.ncbi.nlm.nih.gov/pubmed/24105630",
"http://www.ncbi.nlm.nih.gov/pubmed/16332594",
"http://www.ncbi.nlm.nih.gov/pubmed/15637691",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.biosemantics.org/jochem#4058240",
"http://www.disease-ontology.org/api/metadata/DOID:0050902",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D061766",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011878",
"https://www.nl... |
58cbf1f402b8c60953000036 | summary | What is the function of the DGAT1 gene product? | [
"Diacylglycerol acyltransferase 1 (DGAT1) catalyzes the final step in the acyl-CoA-dependent triacylglycerol biosynthesis",
"Diacylglycerol acyltransferase 1 (DGAT1) catalyzes the final step in the acyl-CoA-dependent triacylglycerol biosynthesis. . . . . ",
"Diacylglycerol acyltransferase 1 (DGAT1) catalyzes th... | [] | [
"Diacylglycerol acyltransferase 1 (DGAT1) catalyzes the final step in the acyl-CoA-dependent triacylglycerol biosynthesis",
"This genomic area includes the DGAT1 gene, which encodes acyl-CoA:diacylglycerol acyltransferase 1, the key enzyme of triglyceride biosynthesis.",
"Diacylglycerol acyltransferase (DGAT1) ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17592768",
"http://www.ncbi.nlm.nih.gov/pubmed/21264296",
"http://www.ncbi.nlm.nih.gov/pubmed/15834126",
"http://www.ncbi.nlm.nih.gov/pubmed/15797871",
"http://www.ncbi.nlm.nih.gov/pubmed/23539897",
"http://www.ncbi.nlm.nih.gov/pubmed/25687632",
"http://www.ncbi.nlm.n... | [] | [
"http://www.uniprot.org/uniprot/DGAT1_DICDI",
"http://www.uniprot.org/uniprot/DGAT1_ARATH",
"http://www.uniprot.org/uniprot/DGAT1_CHLAE",
"http://www.uniprot.org/uniprot/DGAT1_HUMAN",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D051048",
"http://www.uniprot.org/unipr... |
58bac71222d3005309000013 | factoid | Which histone mutation is associated with gliomas? | [
"Pediatric central nervous system tumors are the most common solid tumor of childhood. Over 70% of diffuse intrinsic pediatric gliomas, an aggressive brainstem tumor, harbor heterozygous mutations that create a K27M amino acid substitution (methionine replaces lysine 27) in the tail of histone H3.3.",
"Over 70% o... | [
"K27M in H3.3"
] | [
"Over 70% of diffuse intrinsic pediatric gliomas, an aggressive brainstem tumor, harbor heterozygous mutations that create a K27M amino acid substitution (methionine replaces lysine 27) in the tail of histone H3.3",
"We show that H3.3K27M expression synergizes with p53 loss and PDGFRA activation in neural progeni... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26957305",
"http://www.ncbi.nlm.nih.gov/pubmed/24242757",
"http://www.ncbi.nlm.nih.gov/pubmed/27034984",
"http://www.ncbi.nlm.nih.gov/pubmed/27701736",
"http://www.ncbi.nlm.nih.gov/pubmed/26297251",
"http://www.ncbi.nlm.nih.gov/pubmed/27392443",
"http://www.ncbi.nlm.n... | [] | [] |
588383172305cd7e21000004 | yesno | Are there canonical marks of active chromatin in developmentally regulated genes? | [
"No. The transcription of genes temporally regulated during fly and worm development occurs in the absence of canonically active histone modifications. Conversely, strong chromatin marking is related to transcriptional and post-transcriptional stability, an association also observed in mammals. Consequently, chroma... | [
"no"
] | [
"Absence of canonical marks of active chromatin in developmentally regulated genes.",
"The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally re... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26280901"
] | [] | [
"http://amigo.geneontology.org/amigo/term/GO:0035327",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018507"
] |
587f60f892a5b8ad44000004 | summary | What is the purpose of HaploReg v4? | [
"HaploReg v4 enables the systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease."
] | [] | [
"HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease.",
"Since first launching the website in 2011, we have greatly expanded HaploReg, increasing the number of chromatin state maps to 127 reference epigenomes from ENCODE 2012 and... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26657631",
"http://www.ncbi.nlm.nih.gov/pubmed/27539526"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D056726"
] |
58c6a6c502b8c60953000027 | list | Which are the typical symptoms of Ménière's disease? | [
"The typical symptoms of Ménière's disease are:\n1) sensorineural hearing loss, \n2) vertigo and \n3) tinnitus."
] | [
"sensorineural hearing loss",
"hypoacusia",
"vertigo",
"dizziness",
"tinnitus"
] | [
"To evaluate the onset of vertigo, hearing loss and tinnitus in Ménière's disease and the associated endolymphatic hydrops (EH) of the inner ear.",
"We suggest that a 3T MRI measurement should be carried out in patients with sensory-neural hearing loss, vertigo and tinnitus, 4 h after the intravenous injection of... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12806289",
"http://www.ncbi.nlm.nih.gov/pubmed/3631415",
"http://www.ncbi.nlm.nih.gov/pubmed/18046258",
"http://www.ncbi.nlm.nih.gov/pubmed/15198043",
"http://www.ncbi.nlm.nih.gov/pubmed/22705835",
"http://www.ncbi.nlm.nih.gov/pubmed/1896679",
"http://www.ncbi.nlm.nih... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008575",
"http://www.disease-ontology.org/api/metadata/DOID:9849"
] |
58cdb41302b8c60953000042 | factoid | What tissue is most affected in Ehlers-Danlos syndromes? | [
"the ehlers-danlos syndromes (eds) are a group of connective tissue disorders characterized by triad of joint hypermobility, skin extensibility, and tissue fragility.",
"The Ehlers-Danlos syndromes (EDS) are a group of connective tissue disorders characterized by triad of joint hypermobility, skin extensibility, ... | [
"connective tissue"
] | [
"The Ehlers-Danlos syndromes (EDS) are a group of connective tissue disorders characterized by triad of joint hypermobility, skin extensibility, and tissue fragility. ",
"Ehlers-Danlos syndromes (EDSs) constitute a rare group of inherited connective tissue diseases, characterized by multisystemic manifestations a... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26958560",
"http://www.ncbi.nlm.nih.gov/pubmed/15589118",
"http://www.ncbi.nlm.nih.gov/pubmed/26452443",
"http://www.ncbi.nlm.nih.gov/pubmed/22981642",
"http://www.ncbi.nlm.nih.gov/pubmed/25103963",
"http://www.ncbi.nlm.nih.gov/pubmed/15817074",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004535",
"http://www.disease-ontology.org/api/metadata/DOID:13359",
"http://www.disease-ontology.org/api/metadata/DOID:14759",
"http://www.disease-ontology.org/api/metadata/DOID:14757",
"http://www.disease-ontology.org/api/m... |
589a246778275d0c4a00002f | summary | What is Mondor's disease? | [
"Mondor's disease is a rare benign and self-limiting condition characterized by thrombophlebitis of the superficial veins of the anterolateral thoracoabdominal wall and genital area."
] | [] | [
"INTRODUCTION: Mondor's disease is a rare superficial thrombophlebitis, historically involving the thoracic venous system of women. ",
"Mondor's disease is a rare benign and self-limiting condition characterized by thrombophlebitis of the superficial veins of the anterolateral thoracoabdominal wall.",
"Mondor's... | [
"http://www.ncbi.nlm.nih.gov/pubmed/1562972",
"http://www.ncbi.nlm.nih.gov/pubmed/21855258",
"http://www.ncbi.nlm.nih.gov/pubmed/24989360",
"http://www.ncbi.nlm.nih.gov/pubmed/25960806",
"http://www.ncbi.nlm.nih.gov/pubmed/22421473",
"http://www.ncbi.nlm.nih.gov/pubmed/19608071",
"http://www.ncbi.nlm.ni... | [] | [] |
58ce5c7c1f5fb2b734000001 | list | List metalloenzyme inhibitors. | [
"Foscarnet\nVT-1129\nVT-1161 \nBB-3497\nhydroxamate molecules\nsiderophores"
] | [
"VT-1129",
"VT-1161",
"BB-3497",
"hydroxamate molecules",
"siderophores",
"Foscarnet"
] | [
" Clinically approved inhibitors were selected as well as several other reported metalloprotein inhibitors in order to represent a broad range of metal binding groups (MBGs), including hydroxamic acid, carboxylate, hydroxypyridinonate, thiol, and N-hydroxyurea functional groups.",
"A total of 21 different raltegr... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19949750",
"http://www.ncbi.nlm.nih.gov/pubmed/21046516",
"http://www.ncbi.nlm.nih.gov/pubmed/21189019",
"http://www.ncbi.nlm.nih.gov/pubmed/11551755",
"http://www.ncbi.nlm.nih.gov/pubmed/22308350",
"http://www.ncbi.nlm.nih.gov/pubmed/17314045",
"http://www.ncbi.nlm.n... | [] | [] |
58c2556302b8c6095300001f | summary | How are immediate early genes (IEG) defined? | [
"this class of genes is experimentally defined by their transcription following primary infection or reactivation in the presence of inhibitors of protein synthesis. Immediate-early (IE) genes are the first class of viral genes expressed after primary infection or reactivation.",
"this class of genes is experimen... | [] | [
"Immediate-early (IE) genes are the first class of viral genes expressed after primary infection or reactivation.",
"this class of genes is experimentally defined by their transcription following primary infection or reactivation in the presence of inhibitors of protein synthesis."
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/8783263",
"http://www.ncbi.nlm.nih.gov/pubmed/11222693",
"http://www.ncbi.nlm.nih.gov/pubmed/19581597",
"http://www.ncbi.nlm.nih.gov/pubmed/15507712"
] | [] | [] |
58de71fa8acda3452900002c | list | Which proteins remove H2A.Z in the yeast Saccharomyces cerevisiae? | [
"Removal of H2A.Z by INO80 promotes homologous recombination Budding yeast INO80 can remove H2A.Z/H2B dimers from chromatin and replace them with H2A/H2B dimers. Here, we show that H2A.Z in human cells is indeed rapidly removed from chromatin flanking DNA damage by INO80.",
"Here, we show that H2A.Z in human cell... | [
"INO80",
"ANP32E"
] | [
"Removal of H2A.Z by INO80 promotes homologous recombination",
"Budding yeast INO80 can remove H2A.Z/H2B dimers from chromatin and replace them with H2A/H2B dimers.",
"Here, we show that H2A.Z in human cells is indeed rapidly removed from chromatin flanking DNA damage by INO80.",
"We also report that the hist... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26982580",
"http://www.ncbi.nlm.nih.gov/pubmed/26142279"
] | [] | [] |
587f7a69d8d850a152000001 | factoid | Which library is used for fixed-length approximate string matching? | [
"libFLASM is a free open-source C++ software library for solving fixed-length approximate string matching under both the edit and the Hamming distance models."
] | [
"libFLASM"
] | [
"libFLASM: a software library for fixed-length approximate string matching.",
"We present and make available libFLASM, a free open-source C++ software library for solving fixed-length approximate string matching under both the edit and the Hamming distance models. Moreover we describe how fixed-length approximate... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27832739"
] | [] | [] |
589206fc49702f2e01000003 | yesno | Are there methods for generating highly multiplexed ChIP-seq libraries? | [
"Yes. There are methods for generating highly multiplexed ChIP-seq libraries."
] | [
"yes"
] | [
"A method for generating highly multiplexed ChIP-seq libraries.",
"The barcoding of next generation sequencing libraries has become an essential part of the experimental design. Barcoding not only allows the sequencing of more than one sample per lane, but also reduces technical bias. However, current barcoding s... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24885602"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015698",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D047369",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D056656"
] |
58cdb80302b8c60953000043 | yesno | Is Doxorubicin cardiotoxic? | [
"Doxorubicin (DOXO) is widely used to treat solid tumors. However, its clinical use is limited by side effects including serious cardiotoxicity due to cardiomyocyte damage",
"Doxorubicin (DOXO) is widely used to treat solid tumors. However, its clinical use is limited by side effects including serious cardiotoxic... | [
"yes"
] | [
"Doxorubicin (DOXO) is widely used to treat solid tumors. However, its clinical use is limited by side effects including serious cardiotoxicity due to cardiomyocyte damage. ",
"The results provide direct evidence for the role of catalase in doxorubicin cardiotoxic responses.",
"These results do not support the ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24382354",
"http://www.ncbi.nlm.nih.gov/pubmed/25885550",
"http://www.ncbi.nlm.nih.gov/pubmed/21057569",
"http://www.ncbi.nlm.nih.gov/pubmed/19103993",
"http://www.ncbi.nlm.nih.gov/pubmed/6734434",
"http://www.ncbi.nlm.nih.gov/pubmed/6407163",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:4269440",
"http://www.biosemantics.org/jochem#4085749",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004317",
"http://www.biosemantics.org/jochem#4269440",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB... |
58ca6d3902b8c6095300002c | list | Which diseases are associated with Primary intestinal lymphangiectasia (PIL)? | [
"Primary intestinal lymphangiectasia (PIL) is associated with:\n1) Waldmann's disease and\n2) Hennekam syndrome (HS)."
] | [
"Waldmann's disease",
"Hennekam syndrome",
"HS"
] | [
"Primary intestinal lymphangiectasia (PIL), also known as Waldmann's disease, is an exudative enteropathy resulting from morphologic abnormalities in the intestinal lymphatics. ",
"Secondary hypogammaglobulinemia in Waldmann's disease treated with subcutaneous immunoglobulins.",
"Octreotide in Hennekam syndrome... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26934740",
"http://www.ncbi.nlm.nih.gov/pubmed/22110841",
"http://www.ncbi.nlm.nih.gov/pubmed/23626516",
"http://www.ncbi.nlm.nih.gov/pubmed/26405709",
"http://www.ncbi.nlm.nih.gov/pubmed/15229406",
"http://www.ncbi.nlm.nih.gov/pubmed/16292099",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:4",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=diseases_category",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008201",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exa... |
58de34608acda3452900002b | yesno | Is the mouse Sry gene locus free of repetitive sequences? | [
"We demonstrate that the presence of long inverted repeats (IR) flanking the mouse Sry gene leads to the formation of the Sry circular transcript in cultured cells. We have found that in an in vitro assay, the SRY protein binds to several sites of the Sry gene and especially to a (CA)25 sequence and to a (CAG)30 re... | [
"no"
] | [
"We demonstrate that the presence of long inverted repeats (IR) flanking the mouse Sry gene leads to the formation of the Sry circular transcript in cultured cells",
"Circularization requires the presence of both IR. As few as 400 complementary nt are necessary for this process",
"The presence of the IR does no... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10410901",
"http://www.ncbi.nlm.nih.gov/pubmed/20851541",
"http://www.ncbi.nlm.nih.gov/pubmed/24228692",
"http://www.ncbi.nlm.nih.gov/pubmed/8747544",
"http://www.ncbi.nlm.nih.gov/pubmed/1518820",
"http://www.ncbi.nlm.nih.gov/pubmed/9369180",
"http://www.ncbi.nlm.nih.... | [] | [] |
5892783d49702f2e01000004 | yesno | Is Meis1 implicated in microphthalmia? | [
"Yes. Meis1 coordinates a network of genes implicated in eye development and microphthalmia. Haploinsufficiency of Meis1, which encodes a transcription factor with evolutionarily conserved expression in the embryonic trunk, brain and sensory organs, including the eye, causes microphthalmic traits and visual impairm... | [
"yes"
] | [
"Meis1 coordinates a network of genes implicated in eye development and microphthalmia.",
"Here we show that haploinsufficiency of Meis1, which encodes a transcription factor with evolutionarily conserved expression in the embryonic trunk, brain and sensory organs, including the eye, causes microphthalmic traits ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26253404"
] | [] | [
"http://www.uniprot.org/uniprot/MEIS1_HUMAN",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008850",
"http://www.uniprot.org/uniprot/MITF_MOUSE",
"http://www.uniprot.org/uniprot/MITF_RAT",
"http://www.disease-ontology.org/api/metadata/DOID:10629",
"https://www.nlm.nih... |
5890eb22621ea6ff7e000006 | yesno | Can Pentraxin 3 predict outcomes of sepsis? | [
"Yes, Pentraxin 3 s an objective biochemical marker in diagnosis of sepsis; it is helpful in assessment of severity and prognosis of sepsis; it also has a certain clinical value in the assessment of sepsis cardiovascular function damage."
] | [
"yes"
] | [
"As compared with low serum PTX3and sTWEAK cases, cirrhotic patients with high serum PTX3/sTWEAK levels a have higher probability of new severe infections, severe sepsis, septic shock, type 1 hepatorenal syndrome, in-hospital, and 3-month follow-up mortalities. ",
"Neonates with high nPTX3 concentrations also hav... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15977234",
"http://www.ncbi.nlm.nih.gov/pubmed/25001601",
"http://www.ncbi.nlm.nih.gov/pubmed/25227610",
"http://www.ncbi.nlm.nih.gov/pubmed/26982005",
"http://www.ncbi.nlm.nih.gov/pubmed/27864924",
"http://www.ncbi.nlm.nih.gov/pubmed/26872435",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018805",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000066891",
"http://www.biosemantics.org/jochem#4264880"
] |
589d965a78275d0c4a000049 | factoid | Which polymerase transcribes pri-miRNAs? | [
"Recent evidence indicates that miRNA genes are transcribed by RNA polymerase II (Pol II) we have established a robust in vivo system in which pri-miRNA is transcribed by RNAP II and processed to pre-miRNA in HeLa cell nuclear extracts.",
"Previous studies in vivo reported that processing of primary microRNA (pri... | [
"RNA polymerase II",
"RNAPII"
] | [
"Previous studies in vivo reported that processing of primary microRNA (pri-miRNA) is coupled to transcription by RNA polymerase II (RNAP II) and can occur co-transcriptionally. ",
"we have established a robust in vivo system in which pri-miRNA is transcribed by RNAP II and processed to pre-miRNA in HeLa cell nuc... | [
"http://www.ncbi.nlm.nih.gov/pubmed/18042145",
"http://www.ncbi.nlm.nih.gov/pubmed/26473486",
"http://www.ncbi.nlm.nih.gov/pubmed/18829588",
"http://www.ncbi.nlm.nih.gov/pubmed/26119101",
"http://www.ncbi.nlm.nih.gov/pubmed/20144951",
"http://www.ncbi.nlm.nih.gov/pubmed/21702984",
"http://www.ncbi.nlm.n... | [] | [
"http://amigo.geneontology.org/amigo/term/GO:1902893",
"http://amigo.geneontology.org/amigo/term/GO:1902895",
"http://amigo.geneontology.org/amigo/term/GO:1902894",
"http://amigo.geneontology.org/amigo/term/GO:0061614",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D0123... |
58cbb98c02b8c60953000034 | factoid | Which mutated enzyme is responsible for oculocutaneous 1 (OCA1)-type albinism? | [
"Mutations in the gene for tyrosinase (TYR), the key enzyme in melanin synthesis, are responsible for oculocutaneous 1 (OCA1)-type albinism."
] | [
"tyrosinase",
"TYR"
] | [
"An overview of oculocutaneous albinism: TYR gene mutations in five Colombian individuals",
"To date, 230 mutations in the TYR gene have been reported as responsible for oculocutaneus albinism type 1 worldwide. TYR gene encodes the enzyme tyrosinase involved in the metabolic pathway of melanin synthesis.",
"Mut... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22088535",
"http://www.ncbi.nlm.nih.gov/pubmed/21968110",
"http://www.ncbi.nlm.nih.gov/pubmed/9170158",
"http://www.ncbi.nlm.nih.gov/pubmed/8651291",
"http://www.ncbi.nlm.nih.gov/pubmed/12829739",
"http://www.ncbi.nlm.nih.gov/pubmed/27775880",
"http://www.ncbi.nlm.nih... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:0050632",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016115",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004798",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=F... |
58c99acf02b8c60953000028 | list | Please list 2 treatments for a torn rotator cuff | [
"to compare clinical outcomes between conventional en masse repair and separate double-layer double-row repair for the treatment of delaminated rotator cuff tears.",
"Surgical repair earlier or later than 3 months after injury may result in similar outcomes and patient satisfaction."
] | [
"early surgery",
"later surgery(3 months after injury)",
"en masse repair",
"double-layer double-row repair",
"arthroscopic",
"open",
"knotless transosseous-equivalent"
] | [
"To compare clinical outcomes between conventional en masse repair and separate double-layer double-row repair for the treatment of delaminated rotator cuff tears",
" To systematically review and evaluate the effectiveness of grafts in the augmentation of large-to-massive rotator cuff repairs",
"To evaluate the... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26564215",
"http://www.ncbi.nlm.nih.gov/pubmed/26912284",
"http://www.ncbi.nlm.nih.gov/pubmed/21351612",
"http://www.ncbi.nlm.nih.gov/pubmed/20621893",
"http://www.ncbi.nlm.nih.gov/pubmed/26847487",
"http://www.ncbi.nlm.nih.gov/pubmed/22004636",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:12702",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000070656",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000070636",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exa... |
5890f4ab621ea6ff7e000008 | summary | What is the role of Laser Interstitial Thermal Therapy in glioma treatment? | [
"Laser Interstitial Thermal Therapy (LITT) is used in treatment of gliomas. LITT can be used effectively for treatment of difficult-to-access high-grade gliomas. More complete coverage of tumor improves progression free survival which can be translated as the extent of resection concept for surgery."
] | [] | [
"OBJECTIVE MR-guided laser-induced thermal therapy (MRgLITT) can be used to treat intracranial tumors, epilepsy, and chronic pain syndromes. ",
"Eight patients had glioblastoma multiforme (GBM), 1 had a previously treated GBM with radiation necrosis, and 1 had a melanoma brain metastasis. ",
"CONCLUSIONS Laser ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26722845",
"http://www.ncbi.nlm.nih.gov/pubmed/26384598",
"http://www.ncbi.nlm.nih.gov/pubmed/27861323",
"http://www.ncbi.nlm.nih.gov/pubmed/27838155",
"http://www.ncbi.nlm.nih.gov/pubmed/23560574",
"http://www.ncbi.nlm.nih.gov/pubmed/27690658",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005910",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D053685",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013812"
] |
58a6db8660087bc10a00002c | factoid | Which protein mediates the replacement of H2A by H2A.Z in the yeast Saccharomyces cerevisiae? | [
"Saccharomyces cerevisiae Swr1, a Swi2/Snf2-related ATPase, is the catalytic core of a multisubunit chromatin remodeling enzyme, called the SWR1 complex, that efficiently replaces conventional histone H2A in nucleosomes with histone H2A.Z. We identified a complex containing 13 different polypeptides associated with... | [
"SWR1"
] | [
"The chromatin remodeler SWR1 mediates site-specific incorporation of H2A.Z by a multi-step histone replacement reaction, evicting histone H2A-H2B from the canonical nucleosome and depositing the H2A.Z-H2B dimer",
"he multisubunit nucleosome-remodeling enzyme complex SWR1, conserved from yeast to mammals, catalyz... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20711347",
"http://www.ncbi.nlm.nih.gov/pubmed/15045029",
"http://www.ncbi.nlm.nih.gov/pubmed/23816883",
"http://www.ncbi.nlm.nih.gov/pubmed/17470967",
"http://www.ncbi.nlm.nih.gov/pubmed/21111233",
"http://www.ncbi.nlm.nih.gov/pubmed/24507717",
"http://www.ncbi.nlm.n... | [] | [] |
58948cb47d9090f353000008 | list | Which are the key players on radial glial specification to ependymal cells? | [
"Mcidas and GemC1/Lynkeas specify embryonic radial glial cells. Both proteins were initially described as cell cycle regulators revealing sequence similarity to Geminin. They are expressed in radial glial cells committed to the ependymal cell lineage during embryogenesis, while overexpression and knock down experim... | [
"Mcidas",
"GemC1",
"Lynkeas"
] | [
"Mcidas and GemC1/Lynkeas specify embryonic radial glial cells.",
"Here we discuss recent findings suggesting that 2 novel molecules, Mcidas and GemC1/Lynkeas are key players on radial glial specification to ependymal cells. Both proteins were initially described as cell cycle regulators revealing sequence simila... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26395491",
"http://www.ncbi.nlm.nih.gov/pubmed/27606337"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D063928",
"http://amigo.geneontology.org/amigo/term/GO:0090213",
"http://amigo.geneontology.org/amigo/term/GO:0009956",
"http://amigo.geneontology.org/amigo/term/GO:0021531",
"http://amigo.geneontology.org/amigo/term/GO:00218... |
58b5320e22d3005309000002 | yesno | Is ocular melanosis a risk factor for uveal melanoma? | [
"Yes, ocular melanosis (melanosis oculi) is a risk factor for uveal melanoma."
] | [
"yes"
] | [
"Ocular/oculodermal (oculo[dermal]) melanocytosis is a congenital periocular pigmentary condition that can lead to the development of uveal melanoma, estimated at 1 in 400 affected patients.",
"Melanosis oculi is often underestimated as a risk factor for uveal melanoma and glaucoma. Ophthalmic surveillance, every... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21670341",
"http://www.ncbi.nlm.nih.gov/pubmed/12647250",
"http://www.ncbi.nlm.nih.gov/pubmed/9442799",
"http://www.ncbi.nlm.nih.gov/pubmed/8292886",
"http://www.ncbi.nlm.nih.gov/pubmed/23681424",
"http://www.ncbi.nlm.nih.gov/pubmed/6677847",
"http://www.ncbi.nlm.nih.... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008545",
"http://www.disease-ontology.org/api/metadata/DOID:1909",
"http://www.disease-ontology.org/api/metadata/DOID:6566",
"http://www.disease-ontology.org/api/metadata/DOID:6039",
"http://www.disease-ontology.org/api/meta... |
58cd633c02b8c6095300003a | summary | What is known about telomere length shortening and stress? | [
"A significant relationship between more perceived stress and shorter telomere length is consistent with theoretical frameworks positing that stress induces physiological changes that result in shortened telomeres."
] | [] | [
"A significant relationship between more perceived stress and shorter telomere length is consistent with theoretical frameworks positing that stress induces physiological changes that result in shortened telomeres. ",
"Psychological stress contributes to numerous diseases and may do so in part through damage to t... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25393133",
"http://www.ncbi.nlm.nih.gov/pubmed/26853993",
"http://www.ncbi.nlm.nih.gov/pubmed/25070535",
"http://www.ncbi.nlm.nih.gov/pubmed/26919486"
] | [] | [] |
5895f7e978275d0c4a000001 | factoid | What fruit causes Jamaican vomiting sickness? | [
"Jamaican Vomiting Sickness is caused by ingestion of the unripe arils of the Ackee fruit, its seeds and husks."
] | [
"Ackee fruit"
] | [
"The aril of the unripe fruit has high concentrations of HGA, the cause of Jamaican vomiting sickness, which is very often fatal.",
"In 1976, over 100 years after Jamaican vomiting sickness (JVS) was first reported, the cause of JVS was linked to the ingestion of the toxin hypoglycin A produced by ackee fruit. ",... | [
"http://www.ncbi.nlm.nih.gov/pubmed/6488562",
"http://www.ncbi.nlm.nih.gov/pubmed/8185109",
"http://www.ncbi.nlm.nih.gov/pubmed/26324727",
"http://www.ncbi.nlm.nih.gov/pubmed/23259140",
"http://www.ncbi.nlm.nih.gov/pubmed/16099087",
"http://www.ncbi.nlm.nih.gov/pubmed/3548729",
"http://www.ncbi.nlm.nih.... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015984",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005638"
] |
588f9950ed9bbee70d000002 | factoid | Which gene is mutated in the Karak syndrome? | [
"PLA2G6 gene is mutated in the Karak syndrome."
] | [
"PLA2G6"
] | [
"Mutations in PLA2G6 have been associated with disorders such as infantile neuroaxonal dystrophy, neurodegeneration with brain iron accumulation type II and Karak syndrome",
"Mutations in PLA2G6 gene have variable phenotypic outcome including infantile neuroaxonal dystrophy, atypical neuroaxonal dystrophy, idiopa... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16783378",
"http://www.ncbi.nlm.nih.gov/pubmed/26001724",
"http://www.ncbi.nlm.nih.gov/pubmed/20938027",
"http://www.ncbi.nlm.nih.gov/pubmed/27884548",
"http://www.ncbi.nlm.nih.gov/pubmed/18443314",
"http://www.ncbi.nlm.nih.gov/pubmed/24130795"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005796",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013577",
"http://www.disease-ontology.org/api/metadata/DOID:225"
] |
587e392d2420191125000001 | summary | What is LedPred? | [
"LedPred is an R/bioconductor package to predict regulatory sequences using support vector machines. LedPred is provided as an R/Bioconductor package connected to an online server to avoid installation of non-R software. Due to the heterogeneous CRM feature integration, LedPred excels at the prediction of regulator... | [] | [
"LedPred: an R/bioconductor package to predict regulatory sequences using support vector machines",
"Here, we present LedPred, a flexible SVM workflow that predicts new regulatory sequences based on the annotation of known CRMs, which are associated to a large variety of feature types. LedPred is provided as an R... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26628586"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D060388",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012045"
] |
5896d3e278275d0c4a000012 | yesno | Is siltuximab effective for Castleman disease? | [
"Yes, siltuximab , a chimeric human-mouse monoclonal antibody to IL6, is approved for the treatment of patients with multicentric Castleman disease who are human immunodeficiency virus negative and human herpesvirus-8 negative."
] | [
"yes"
] | [
"Siltuximab: a targeted therapy for idiopathic multicentric Castleman disease.",
"The recent approvals in North America, Europe and Brazil of siltuximab, a monoclonal antibody against IL-6, for iMCD now provide a safe and effective therapy that targets a key aspect of pathogenesis. In the first ever randomized, p... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25310208",
"http://www.ncbi.nlm.nih.gov/pubmed/26124203",
"http://www.ncbi.nlm.nih.gov/pubmed/26749192",
"http://www.ncbi.nlm.nih.gov/pubmed/25601959",
"http://www.ncbi.nlm.nih.gov/pubmed/26634298",
"http://www.ncbi.nlm.nih.gov/pubmed/25110138",
"http://www.ncbi.nlm.n... | [] | [] |
58cdbaf302b8c60953000044 | summary | What are Degrons? | [
"Specific signals (degrons) regulate protein turnover mediated by the ubiquitin-proteasome system.",
"Portable degradation sequences, or degrons, have the ability to bind to E3 ligases and promote substrate ubiquitination when the sequence is presented in isolation or appended to other entities such as fluorescen... | [] | [
"Specific signals (degrons) regulate protein turnover mediated by the ubiquitin-proteasome system.",
"Portable degradation sequences, or degrons, have the ability to bind to E3 ligases and promote substrate ubiquitination when the sequence is presented in isolation or appended to other entities such as fluorescen... | [
"http://www.ncbi.nlm.nih.gov/pubmed/7731961",
"http://www.ncbi.nlm.nih.gov/pubmed/23960079",
"http://www.ncbi.nlm.nih.gov/pubmed/10545113",
"http://www.ncbi.nlm.nih.gov/pubmed/20924402",
"http://www.ncbi.nlm.nih.gov/pubmed/16606826",
"http://www.ncbi.nlm.nih.gov/pubmed/22577142",
"http://www.ncbi.nlm.ni... | [] | [] |
58ce9bf1d46b5c2951000002 | factoid | Which disease is associated with mutated Sox2? | [
"SOX2 anophthalmia syndrome is an uncommon autosomal dominant syndrome caused by mutations in the SOX2 gene and clinically characterized by severe eye malformations (anophthalmia/microphthalmia) and extraocular anomalies mainly involving brain, esophagus, and genitalia."
] | [
"SOX2 anophthalmia syndrome"
] | [
"Anophthalmia and microphthalmia (A/M) are developmental ocular malformations defined as the complete absence or reduction in size of the eye. A/M is a highly heterogeneous disorder with SOX2 and FOXE3 playing major roles in dominant and recessive pedigrees, respectively;",
"anophthalmia/microphthalmia (AM) or an... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25542770",
"http://www.ncbi.nlm.nih.gov/pubmed/26893459",
"http://www.ncbi.nlm.nih.gov/pubmed/26250054",
"http://www.ncbi.nlm.nih.gov/pubmed/26130484"
] | [] | [] |
58cd522902b8c60953000038 | yesno | Is the enzyme EPRS phosphorylated? | [
"Yes, EPRS is dually phosphorylated by cyclin-dependent kinase 5 (Cdk5) at Ser(886) and then by a Cdk5-dependent-AGC kinase at Ser(999)"
] | [
"yes"
] | [
"Phosphorylation of glutamyl-prolyl tRNA synthetase (EPRS) has been investigated extensively in our laboratory for more than a decade, and has served as an archetype for studies of other AARSs.",
"EPRS is dually phosphorylated by cyclin-dependent kinase 5 (Cdk5) at Ser(886) and then by a Cdk5-dependent-AGC kinase... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27729295",
"http://www.ncbi.nlm.nih.gov/pubmed/21220307",
"http://www.ncbi.nlm.nih.gov/pubmed/19647514",
"http://www.ncbi.nlm.nih.gov/pubmed/23071094"
] | [] | [] |
58bfd8e902b8c60953000018 | factoid | Which disease the skin condition Necrobiosis lipoidica diabeticorum is associated to? | [
"Necrobiosis lipoidica diabeticorum (NLD) is a rare, granulomatous inflammatory skin disease of unknown origin, sometimes associated with diabetes mellitus."
] | [
"Diabetes mellitus"
] | [
"Necrobiosis lipoidica diabeticorum (NLD) is a chronic condition, which is characterized by single or multiple lesions on the legs, and occurs in 0.3% of patients with diabetes.",
"Necrobiosis lipoidica (NL) is a rare chronic granulomatous dermatitis that usually appears in the lower extremities. It affects about... | [
"http://www.ncbi.nlm.nih.gov/pubmed/11259927",
"http://www.ncbi.nlm.nih.gov/pubmed/24575162",
"http://www.ncbi.nlm.nih.gov/pubmed/17429587",
"http://www.ncbi.nlm.nih.gov/pubmed/730866",
"http://www.ncbi.nlm.nih.gov/pubmed/8261754",
"http://www.ncbi.nlm.nih.gov/pubmed/16060710",
"http://www.ncbi.nlm.nih.... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009335",
"http://www.disease-ontology.org/api/metadata/DOID:4",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=diseases_category",
"http://www.disease-ontology.org/api/metadata/DOID:3486"
] |
589474467d9090f353000006 | summary | What is the role of Lysine 2-hydroxyisobutyrylation? | [
"Lysine 2-hydroxyisobutyrylation (Khib) is a widely distributed active histone mark. This histone mark was initially identified by MS and then validated by chemical and biochemical methods. Histone Khib shows distinct genomic distributions from histone Kac or histone Kcr during male germ cell differentiation. In ma... | [] | [
"Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.",
"We report the identification of a new type of histone mark, lysine 2-hydroxyisobutyrylation (Khib), and identify the mark at 63 human and mouse histone Khib sites, including 27 unique lysine sites that are not known to be modified by... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24681537"
] | [] | [
"http://www.biosemantics.org/jochem#4005689",
"http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:4275269",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008239",
"http://www.biosemantics.org/jochem#4278518",
"http://www.biosemantics.org/jochem#http:... |
58cd59cb02b8c60953000039 | list | List diseases associated with the Dopamine Receptor D4 (DRD4). | [
"The 5-repeat allele of a common length polymorphism in the gene that encodes the dopamine D4 receptor (DRD4) is robustly associated with the risk of attention deficit hyperactivity disorder (ADHD)."
] | [
"attention deficit hyperactivity disorder",
"ADHD",
"susceptibility to neuropsychiatric diseases"
] | [
"The 5-repeat allele of a common length polymorphism in the gene that encodes the dopamine D4 receptor (DRD4) is robustly associated with the risk of attention deficit hyperactivity disorder (ADHD) and substantially exists in Asian populations, which have a lower ADHD prevalence.",
"The variable number of tandem ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22610946",
"http://www.ncbi.nlm.nih.gov/pubmed/25659462",
"http://www.ncbi.nlm.nih.gov/pubmed/25983551"
] | [] | [] |
58b548d722d3005309000005 | list | Which bacteria cause diphtheria? | [
"Diphtheria is caused by the bacteria:\n1) Corynebacterium ulcerans and \n2) Corynebacterium diphtheriae."
] | [
"Corynebacterium ulcerans",
"C. ulcerans",
"Corynebacterium diphtheriae",
"C. diphtheriae"
] | [
"Corynebacterium ulcerans is a zoonotic pathogen that can produce diphtheria toxin and causes an illness categorized as diphtheria in the European Union because its clinical appearance is similar to that of diphtheria caused by Corynebacterium diphtheriae. ",
"The zoonotic bacterium Corynebacterium ulcerans may b... | [
"http://www.ncbi.nlm.nih.gov/pubmed/8784575",
"http://www.ncbi.nlm.nih.gov/pubmed/24403054",
"http://www.ncbi.nlm.nih.gov/pubmed/7766139",
"http://www.ncbi.nlm.nih.gov/pubmed/23981100",
"http://www.ncbi.nlm.nih.gov/pubmed/14532240",
"http://www.ncbi.nlm.nih.gov/pubmed/23357389",
"http://www.ncbi.nlm.nih... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001419",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003354",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003352",
"https://www.nlm.nih.gov/cgi/me... |
58cd7fed02b8c6095300003f | factoid | What is the function of calcium-sensing receptor (CaSR)? | [
"The calcium-sensing receptor (CaSR) is a G-protein-coupled receptor that plays an essential role in maintaining calcium homeostasis.\nThe CaSR is a key regulator for such diverse processes as hormone secretion, gene expression, inflammation, proliferation, differentiation, and apoptosis. Due to this pleiotropy, th... | [
"The calcium-sensing receptor (CaSR) is a G-protein-coupled receptor that plays an essential role in maintaining calcium homeostasis."
] | [
"The calcium-sensing receptor (CaSR) is a G-protein-coupled receptor that plays an essential role in maintaining calcium homeostasis. ",
"The calcium-sensing receptor (CaSR) plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary calcium excretion. The CaSR is u... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21566074",
"http://www.ncbi.nlm.nih.gov/pubmed/26386835",
"http://www.ncbi.nlm.nih.gov/pubmed/23856267",
"http://www.ncbi.nlm.nih.gov/pubmed/26608608",
"http://www.ncbi.nlm.nih.gov/pubmed/26261299"
] | [] | [] |
589a245a78275d0c4a000026 | list | List drug that were evaluated in the CHAMP trial for migraine. | [
"Childhood and Adolescent Migraine Prevention (CHAMP) trial evaluated effectiveness of amitriptyline and topiramate in the prevention of migraine in children and adolescents."
] | [
"amitriptyline",
"topiramate"
] | [
"OBJECTIVE: To describe baseline headache characteristics of children and adolescents participating in a multicenter, randomized, double-blinded, placebo-controlled, comparative effectiveness study of amitriptyline, topiramate, and placebo for the prevention of migraine (CHAMP Study).",
"Childhood and Adolescent ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23594025",
"http://www.ncbi.nlm.nih.gov/pubmed/27039826",
"http://www.ncbi.nlm.nih.gov/pubmed/27788026"
] | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:6364",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016430"
] |
58cd90c202b8c60953000040 | factoid | What is the role of IL-18BP? | [
"IL-18 binding protein (IL-18BP) is a natural inhibitor of IL-18. The balance between IL-18 and IL-18BP has an important role in the inflammatory setting."
] | [
"IL-18 binding protein (IL-18BP) is a natural inhibitor of IL-18. The balance between IL-18 and IL-18BP has an important role in the inflammatory setting."
] | [
"Interleukin 18--binding protein ameliorates liver ischemia--reperfusion injury.",
" IL-18BP exhibited anti-inflammatory, antioxidant, and protective effects in I/R-mediated hepatic injury via regulating some liver enzyme activities and cytokine levels. ",
"Because of IL-18's potential pro-inflammatory and tiss... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26782741",
"http://www.ncbi.nlm.nih.gov/pubmed/26898120",
"http://www.ncbi.nlm.nih.gov/pubmed/27914933",
"http://www.ncbi.nlm.nih.gov/pubmed/25548255",
"http://www.ncbi.nlm.nih.gov/pubmed/25807634",
"http://www.ncbi.nlm.nih.gov/pubmed/25692120",
"http://www.ncbi.nlm.n... | [] | [] |
58adc1ff9ef3c34033000006 | factoid | Which protein mediates gene loop formation in the yeast S. cerevisiae? | [
"Moreover, looping is dependent upon the general transcription factor TFIIB: the E62K (glutamic acid 62 --> lysine) form of TFIIB adversely affects looping at every gene tested, including BLM10, SAC3, GAL10, SEN1, and HEM3. TFIIB crosslinks to both the promoter and terminator regions of the PMA1 and BLM10 genes, an... | [
"TFIIB"
] | [
"A transcription-independent role for TFIIB in gene looping.",
"Moreover, looping is dependent upon the general transcription factor TFIIB: the E62K (glutamic acid 62 -->lysine) form of TFIIB adversely affects looping at every gene tested, including BLM10, SAC3, GAL10, SEN1, and HEM3",
"TFIIB crosslinks to both... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24124207",
"http://www.ncbi.nlm.nih.gov/pubmed/22081613",
"http://www.ncbi.nlm.nih.gov/pubmed/17803944",
"http://www.ncbi.nlm.nih.gov/pubmed/21835917",
"http://www.ncbi.nlm.nih.gov/pubmed/19602510",
"http://www.ncbi.nlm.nih.gov/pubmed/18550805"
] | [] | [] |
589a246178275d0c4a00002b | list | Which two drugs were compared in the ARISTOTLE Trial? | [
"Apixaban for Reduction In Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial compared apixaban and warfarin."
] | [
"apixaban",
"warfarin"
] | [
"METHODS: We analyzed patients from ARISTOTLE, a randomized trial of 18,201 patients with atrial fibrillation comparing the effects of apixaban versus warfarin on the risk of stroke or systemic embolism. ",
" In this study we evaluated the relationship between inflammatory biomarkers at baseline and future risk o... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22277459",
"http://www.ncbi.nlm.nih.gov/pubmed/26424386",
"http://www.ncbi.nlm.nih.gov/pubmed/25294786",
"http://www.ncbi.nlm.nih.gov/pubmed/24657685",
"http://www.ncbi.nlm.nih.gov/pubmed/27463942",
"http://www.ncbi.nlm.nih.gov/pubmed/25497244",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017428"
] |
5891c754621ea6ff7e000011 | summary | What is REVIGO? | [
"REVIGO summarizes and visualizes long lists of gene ontology terms.",
"REVIGO is a Web server that summarizes long, unintelligible lists of GO terms by finding a representative subset of the terms using a simple clustering algorithm that relies on semantic similarity measures. Furthermore, REVIGO visualizes this... | [] | [
"REVIGO summarizes and visualizes long lists of gene ontology terms.",
"REVIGO is a Web server that summarizes long, unintelligible lists of GO terms by finding a representative subset of the terms using a simple clustering algorithm that relies on semantic similarity measures. Furthermore, REVIGO visualizes this... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21789182"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D063990"
] |
5890dcba621ea6ff7e000003 | summary | What is the mechanism of action of onartuzumab? | [
"Onartuzumab is monoclonal antibody targeting MET. It works by inhibiting MET. Onartuzumab was tested for treatment of non-small cell lung carcinoma, adenocarcinoma of the stomach and gastroesophageal Junction, and recurrent glioblastoma."
] | [] | [
" In this study, e-training was used to train board-certified pathologists to evaluate non-small cell lung carcinoma for eligibility for treatment with onartuzumab, a MET-inhibiting agent.",
"A Randomized Phase II Study of FOLFOX With or Without the MET Inhibitor Onartuzumab in Advanced Adenocarcinoma of the Stom... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23922054",
"http://www.ncbi.nlm.nih.gov/pubmed/22917884",
"http://www.ncbi.nlm.nih.gov/pubmed/25806189",
"http://www.ncbi.nlm.nih.gov/pubmed/27937096",
"http://www.ncbi.nlm.nih.gov/pubmed/25074413",
"http://www.ncbi.nlm.nih.gov/pubmed/27349303",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020228"
] |
58c0836102b8c6095300001c | yesno | Is there a relationship between B cells and Multiple Sclerosis? | [
"MS patients with high neurodegeneration have changes in B cells characterized by down-regulation of B-cell-specific genes and increased activation status"
] | [
"yes"
] | [
"These results suggest that RRMS patients with radiological phenotypes showing high neurodegeneration have changes in B cells characterized by down-regulation of B-cell-specific genes and increased activation status",
"Although the exact etiology is still obscure, the leading hypothesis behind MS relapses is acut... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25267439",
"http://www.ncbi.nlm.nih.gov/pubmed/19996075",
"http://www.ncbi.nlm.nih.gov/pubmed/26857494",
"http://www.ncbi.nlm.nih.gov/pubmed/26810546",
"http://www.ncbi.nlm.nih.gov/pubmed/25666875",
"http://www.ncbi.nlm.nih.gov/pubmed/26604134",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001402",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D009103",
"http://www.disease-ontology.org/api/metadata/DOID:2377"
] |
58bfd0db02b8c60953000017 | factoid | Which virus type causes Molluscum contagiosum? | [
"Molluscum contagiosum virus (MCV) is a human poxvirus that causes tumor-like skin lesions."
] | [
"human poxvirus"
] | [
"Molluscum contagiosum virus (MCV), a poxvirus pathogenic for humans, replicates well in human skin in vivo, but not in vitro in standard monolayer cell cultures.",
"Molluscum contagiosum virus (MCV) is a poxvirus that causes tumor-like skin lesions. ",
"Molluscum contagiosum poxvirus (MCV) type 1 and type 2 en... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16390992",
"http://www.ncbi.nlm.nih.gov/pubmed/23372568",
"http://www.ncbi.nlm.nih.gov/pubmed/24155912",
"http://www.ncbi.nlm.nih.gov/pubmed/18950398",
"http://www.ncbi.nlm.nih.gov/pubmed/18616033",
"http://www.ncbi.nlm.nih.gov/pubmed/9275219",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:8867",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008977",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008976"
] |
58cea0768acda34529000001 | summary | Which disease(s) are caused by HEX A deficiency? | [
"Mutations in the HEX A gene, encoding the alpha-subunit of beta-hexosaminidase A (Hex A), are the cause of Tay-Sachs disease as well as of juvenile, chronic, and adult GM2 gangliosidoses."
] | [] | [
"Tay-Sachs disease (TSD) is a recessively inherited neurodegenerative disorder due to mutations in the HEXA gene resulting in a beta-hexosaminidase A (Hex A) deficiency. ",
"Rapid identification of HEXA mutations in Tay-Sachs patients.",
"Tay-Sachs disease (TSD) is a recessively inherited neurodegenerative diso... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25606403",
"http://www.ncbi.nlm.nih.gov/pubmed/20100466",
"http://www.ncbi.nlm.nih.gov/pubmed/7717398",
"http://www.ncbi.nlm.nih.gov/pubmed/2220809",
"http://www.ncbi.nlm.nih.gov/pubmed/15108204",
"http://www.ncbi.nlm.nih.gov/pubmed/9073025"
] | [] | [] |
58cb305c02b8c60953000032 | summary | What is Behçet's disease | [
"Behet's disease (BD) is a complex chronic relapsing inflammatory disorder of unknown etiology.",
"Behçet's disease (BD) is a complex chronic relapsing inflammatory disorder of unknown etiology.",
"Behçet's disease (BD) is a complex chronic relapsing inflammatory disorder of unknown etiology. ",
"behçet's dis... | [] | [
"Behçet's disease (BD) is a complex chronic relapsing inflammatory disorder of unknown etiology. ",
" Behçet disease is a systemic disease of young adults characterized by venous occlusion in both the deep venous and retinal circulations. In severe ocular disease, blindness may occur despite immunosuppressive tre... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22041429",
"http://www.ncbi.nlm.nih.gov/pubmed/26868128",
"http://www.ncbi.nlm.nih.gov/pubmed/22310876",
"http://www.ncbi.nlm.nih.gov/pubmed/25447032",
"http://www.ncbi.nlm.nih.gov/pubmed/10511031",
"http://www.ncbi.nlm.nih.gov/pubmed/26740268",
"http://www.ncbi.nlm.n... | [] | [
"http://www.disease-ontology.org/api/metadata/DOID:13241",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001528",
"http://www.disease-ontology.org/api/metadata/DOID:1670"
] |
58caf86f02b8c60953000030 | yesno | Does Yersinia pestis causes a respiratory infection? | [
"Inhalation of Yersinia pestis results in primary pneumonic plague."
] | [
"yes"
] | [
"Inhalation of Yersinia pestis results in primary pneumonic plague, a highly lethal and rapidly progressing necrotizing pneumonia",
"Yersinia pestis causes the fatal respiratory disease pneumonic plague.",
"Pulmonary infection by Yersinia pestis causes pneumonic plague, a rapidly progressing and often fatal dis... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17041851",
"http://www.ncbi.nlm.nih.gov/pubmed/26463167",
"http://www.ncbi.nlm.nih.gov/pubmed/16239527",
"http://www.ncbi.nlm.nih.gov/pubmed/26123398",
"http://www.ncbi.nlm.nih.gov/pubmed/25928467",
"http://www.ncbi.nlm.nih.gov/pubmed/25974210",
"http://www.ncbi.nlm.n... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015010",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015007",
"http://www.disease-ontology.org/api/metadata/DOID:0050069",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=F... |
58c1b2f702b8c6095300001e | list | List 3 indications for Bupropion | [
"Bupropion is used to treat Obesity, for smoking cessation and for depression"
] | [
"weight loss in obesity",
"smoking cessation",
"depression"
] | [
" For genotype, genes associated with nicotinic acetylcholine receptors (nAChRs) and related proteins have been found to predict response to first-line medications (e.g. nicotine replacement therapy [NRT], bupropion, or varenicline) or quitting over time without a controlled treatment trial. ",
"The approval of d... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17227286",
"http://www.ncbi.nlm.nih.gov/pubmed/16027765",
"http://www.ncbi.nlm.nih.gov/pubmed/16831112",
"http://www.ncbi.nlm.nih.gov/pubmed/9554323",
"http://www.ncbi.nlm.nih.gov/pubmed/16546007",
"http://www.ncbi.nlm.nih.gov/pubmed/12043548",
"http://www.ncbi.nlm.ni... | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016642",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016540",
"http://www.biosemantics.org/jochem#4095874",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&... |
58bde18b02b8c60953000014 | factoid | What is the function of BAX | [
"BAX is a central death regulator that controls apoptosis in normal and cancer cells",
"pro-apoptotic protein Bax"
] | [
"bax promotes Apoptosis"
] | [
"pro-apoptotic protein Bax",
"Bax, a central cell death regulator, is an indispensable gateway to mitochondrial dysfunction and a major proapoptotic member of the B-cell lymphoma 2 (Bcl-2) family proteins that control apoptosis in normal and cancer cells",
"Thus, PP2A may function as a physiological Bax regulat... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19138672",
"http://www.ncbi.nlm.nih.gov/pubmed/12732850",
"http://www.ncbi.nlm.nih.gov/pubmed/17494694",
"http://www.ncbi.nlm.nih.gov/pubmed/24712408",
"http://www.ncbi.nlm.nih.gov/pubmed/27164337",
"http://www.ncbi.nlm.nih.gov/pubmed/8798665",
"http://www.ncbi.nlm.ni... | [] | [
"http://www.uniprot.org/uniprot/BAX_ECOLI",
"http://amigo.geneontology.org/amigo/term/GO:0065009",
"http://www.uniprot.org/uniprot/BAX_BOVIN",
"http://www.uniprot.org/uniprot/BAX_RAT",
"http://www.uniprot.org/uniprot/BAX_HUMAN",
"http://www.uniprot.org/uniprot/BAX_MOUSE"
] |
587f8324d8d850a152000003 | summary | What is the link between Ctf4 and Chl1 in cohesion establishment? | [
"Ctf4 links DNA replication with sister chromatid cohesion establishment by recruiting the Chl1 helicase to the replisome. The Eco1 acetyltransferase, helped by factors including Ctf4 and Chl1, concomitantly acetylates the chromosomal cohesin complex to stabilize its cohesive links.",
"Genetic analyses revealed t... | [] | [
"Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome.",
"The Eco1 acetyltransferase, helped by factors including Ctf4 and Chl1, concomitantly acetylates the chromosomal cohesin complex to stabilize its cohesive links. Here we show that Ctf4 recr... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23334284",
"http://www.ncbi.nlm.nih.gov/pubmed/17222391",
"http://www.ncbi.nlm.nih.gov/pubmed/15226378",
"http://www.ncbi.nlm.nih.gov/pubmed/27397686",
"http://www.ncbi.nlm.nih.gov/pubmed/23036200"
] | [
{
"p": "http://www.w3.org/2004/02/skos/core#prefLabel",
"s": "http://linkedlifedata.com/resource/#_513031343534001D",
"o": "CTF4"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C1427963",
"o": "http://linkedlifedata.com/resource/u... | [
"http://amigo.geneontology.org/amigo/term/GO:0034089",
"http://www.biosemantics.org/jochem#4264134",
"http://amigo.geneontology.org/amigo/term/GO:0034085",
"http://amigo.geneontology.org/amigo/term/GO:0034087",
"http://www.biosemantics.org/jochem#4265011"
] |
58ca5cba02b8c6095300002b | summary | How is primary intestinal lymphangiectasia (PIL) caused? | [
"Primary intestinal lymphangiectasia (PIL) is a rare disorder characterized by diffuse or localized dilation and eventual rupture of the enteric lymphatic vessels in mucosa, submucosa, and/or subserosa. Lymph, rich in all kinds of proteins and lymphocytes, leaks into the gastrointestinal tract via the affected lymp... | [] | [
"Primary intestinal lymphangiectasia (PIL) is a rare disorder of unknown etiology characterized by diffuse or localized dilation and eventual rupture of the enteric lymphatic vessels in mucosa, submucosa, and/or subserosa. Lymph, rich in all kinds of proteins and lymphocytes, leaks into the gastrointestinal tract v... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19853733",
"http://www.ncbi.nlm.nih.gov/pubmed/26217101",
"http://www.ncbi.nlm.nih.gov/pubmed/26962779",
"http://www.ncbi.nlm.nih.gov/pubmed/8650761",
"http://www.ncbi.nlm.nih.gov/pubmed/23229460",
"http://www.ncbi.nlm.nih.gov/pubmed/23316917",
"http://www.ncbi.nlm.ni... | [
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C1418580",
"o": "http://linkedlifedata.com/resource/umls/label/A12036259"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A1203... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008201",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008200",
"http://www.disease-ontology.org/api/metadata/DOID:2402",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find... |
58e115d66fddd3e83e00000a | summary | What are congenital disorders of glycosylation? | [
"Congenital disorders of glycosylation (CDG) are a growing group of inherited metabolic disorders where enzymatic defects in the formation or processing of glycolipids and/or glycoproteins lead to variety of different diseases.\nMore than 100 rare human genetic disorders that result from deficiencies in the differe... | [] | [
"Congenital disorder of glycosylation (CDG), formerly representing a group of diseases due to defects in the biosynthetic pathway of protein N-glycosylation, currently covers a wide range of disorders affecting glycoconjugates. ",
"Congenital disorders of glycosylation form a rapidly growing group of inherited me... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26873821",
"http://www.ncbi.nlm.nih.gov/pubmed/27725718",
"http://www.ncbi.nlm.nih.gov/pubmed/25840006",
"http://www.ncbi.nlm.nih.gov/pubmed/26238249",
"http://www.ncbi.nlm.nih.gov/pubmed/24157261"
] | [] | [] |
587d2b7efe8a08052f000003 | list | Which are the additions of the JASPAR 2016 open-access database of transcription factor binding profiles? | [
"Compared to the JASPAR CORE collection, JASPAR 2016 has been expanded with 494 new TF binding profiles (315 in vertebrates, 11 in nematodes, 3 in insects, 1 in fungi and 164 in plants) and 59 profiles (58 in vertebrates and 1 in fungi) have been updated. The introduced profiles represent an 83% expansion and 10% u... | [
"494 new TF binding profiles (315 in vertebrates, 11 in nematodes, 3 in insects, 1 in fungi and 164 in plants) and updated 59 profiles (58 in vertebrates and 1 in fungi)",
"Updated structural annotation of the TF DNA binding domains (DBDs) following a published hierarchical structural classification",
"130 tran... | [
"For this 2016 release, we expanded the JASPAR CORE collection with 494 new TF binding profiles (315 in vertebrates, 11 in nematodes, 3 in insects, 1 in fungi and 164 in plants) and updated 59 profiles (58 in vertebrates and 1 in fungi). The introduced profiles represent an 83% expansion and 10% update when compare... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26531826"
] | [] | [] |
58d90b968acda3452900000e | summary | What is the function of the protein tafazzin? | [
"Tafazzin is a phospholipid transacylase that transfers acyl chains with unsaturated fatty acids from phospholipids to monolysocardiolipin to generate cardiolipin with unsaturated fatty acids on mitochondrial membrane."
] | [] | [
"Tafazzin is a transacylase that transfers acyl chains with unsaturated fatty acids from phospholipids to monolysocardiolipin to generate cardiolipin with unsaturated fatty acids.",
"Tafazzin (EC 2.3.1.23) is a Phospholipid Transacylase involved in Cardiolipin remodeling on mitochondrial membrane and coded by TAZ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24318983",
"http://www.ncbi.nlm.nih.gov/pubmed/25598000",
"http://www.ncbi.nlm.nih.gov/pubmed/25118650",
"http://www.ncbi.nlm.nih.gov/pubmed/26415690",
"http://www.ncbi.nlm.nih.gov/pubmed/21068380",
"http://www.ncbi.nlm.nih.gov/pubmed/25941633",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/umls/id/C0031843",
"o": "function"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0031843",
"o": "http://linkedlifedata.com/resource/um... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011506",
"http://www.disease-ontology.org/api/metadata/DOID:0050476",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D056889"
] |
58e12ea66fddd3e83e00000e | summary | What are assassin bugs? | [
"The family Reduviidae (Hemiptera: Heteroptera), or assassin bugs, is among the most diverse families of the true bugs, with more than 6,000 species."
] | [] | [
"The complete mitochondrial genome of an assassin bug Peirates arcuatus (Hemiptera: Reduviidae).",
"First complete mitochondrial genome sequence from the tribelocephaline assassin bugs (Hemiptera: Reduviidae).",
"The complete mitochondrial genome (mitogenome) of Opistoplatys sp. was determined, which was the fi... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25996956",
"http://www.ncbi.nlm.nih.gov/pubmed/24438295",
"http://www.ncbi.nlm.nih.gov/pubmed/25689825",
"http://www.ncbi.nlm.nih.gov/pubmed/26249492",
"http://www.ncbi.nlm.nih.gov/pubmed/27058599",
"http://www.ncbi.nlm.nih.gov/pubmed/24884699"
] | [] | [] |
58eb7898eda5a57672000006 | yesno | Are the genes for marneral biosynthesis scattered in the genome of A. thaliana? | [
"These clusters are unlikely to have arisen by horizontal gene transfer, and the mechanisms behind their formation are poorly understood. Here we characterize a second operon-like triterpene cluster (the marneral cluster) from A. thaliana, compare the features of these two clusters, and investigate the evolutionary... | [
"no"
] | [
"Here we characterize a second operon-like triterpene cluster (the marneral cluster) from A. thaliana, compare the features of these two clusters, and investigate the evolutionary events that have led to cluster formation",
"Here we characterize a second operon-like triterpene cluster (the marneral cluster) from ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21876149"
] | [] | [] |
58df3e408acda3452900002d | yesno | Is Dupilumab used for treatment of atopic dermatitis? | [
"Yes, patients treated with dupilumab had marked and rapid improvement in all the evaluated measures of atopic dermatitis disease activity."
] | [
"yes"
] | [
"Dupilumab has demonstrated efficacy in patients with asthma and atopic dermatitis, which are both type 2 helper T-cell-mediated diseases.",
"Background Dupilumab, a human monoclonal antibody against interleukin-4 receptor alpha, inhibits signaling of interleukin-4 and interleukin-13, type 2 cytokines that may be... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27334730",
"http://www.ncbi.nlm.nih.gov/pubmed/27690741",
"http://www.ncbi.nlm.nih.gov/pubmed/26428945",
"http://www.ncbi.nlm.nih.gov/pubmed/25006719",
"http://www.ncbi.nlm.nih.gov/pubmed/26836729",
"http://www.ncbi.nlm.nih.gov/pubmed/27497276",
"http://www.ncbi.nlm.n... | [] | [] |
58cf5c5a8acda34529000003 | factoid | Where is base J found in the genome of Leishmania tarentolae? | [
"Base J (β-D-glucosyl-hydroxymethyluracil) replaces 1% of T in the Leishmania genome and is only found in telomeric repeats (99%) and in regions where transcription starts and stops. Base J is found predominantly in repetitive DNA and correlates with epigenetic silencing of telomeric variant surface glycoprotein ge... | [
"telomeric repeats"
] | [
"Base J (β-D-glucosyl-hydroxymethyluracil) replaces 1% of T in the Leishmania genome and is only found in telomeric repeats (99%) and in regions where transcription starts and stops.",
"Base J is found predominantly in repetitive DNA and correlates with epigenetic silencing of telomeric variant surface glycoprote... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25662217",
"http://www.ncbi.nlm.nih.gov/pubmed/17329373",
"http://www.ncbi.nlm.nih.gov/pubmed/19114062",
"http://www.ncbi.nlm.nih.gov/pubmed/10562569",
"http://www.ncbi.nlm.nih.gov/pubmed/25104019",
"http://www.ncbi.nlm.nih.gov/pubmed/20215442"
] | [] | [] |
587e0116ae05ffb474000002 | factoid | Which tool is available for predicting regulatory interactions from ChIP-seq data? | [
"CisMapper predicts the regulatory targets of a TF using the correlation between a histone mark at the TF's bound sites and the expression of each gene across a panel of tissues. CisMapper is more accurate at predicting the target genes of a TF than the distance-based approaches currently used, and is particularly ... | [
"CisMapper"
] | [
"CisMapper: predicting regulatory interactions from transcription factor ChIP-seq data",
"We present CisMapper, which predicts the regulatory targets of a TF using the correlation between a histone mark at the TF's bound sites and the expression of each gene across a panel of tissues.",
"Using both chromatin co... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27924029"
] | [] | [] |
58c67bf302b8c60953000026 | summary | Where are the unipolar brush cells localized? | [
"Unipolar brush cells (UBCs) are glutamatergic interneurons localized in granule cell regions of the cochlear nucleus and the vestibulocerebellum of cerebellum."
] | [] | [
"Cerebellar unipolar brush cells (UBCs) are glutamatergic interneurons that receive direct input from vestibular afferents in the form of a unique excitatory synapse on their dendritic brush. ",
"Immunostained unipolar brush cells were observed in granule cell regions of the cochlear nucleus and the vestibulocere... | [
"http://www.ncbi.nlm.nih.gov/pubmed/7978355",
"http://www.ncbi.nlm.nih.gov/pubmed/11457596",
"http://www.ncbi.nlm.nih.gov/pubmed/8177517",
"http://www.ncbi.nlm.nih.gov/pubmed/9923978",
"http://www.ncbi.nlm.nih.gov/pubmed/14614902",
"http://www.ncbi.nlm.nih.gov/pubmed/8059339",
"http://www.ncbi.nlm.nih.g... | [
{
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"s": "http://linkedlifedata.com/resource/umls/id/C0392752",
"o": "Localized"
},
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"s": "http://linkedlifedata.com/resource/umls/id/C0392752",
"o": "http://linkedlifedata.com/resource/u... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002477"
] |
58add1d79ef3c34033000008 | list | Which driver mutations have been identified for Diffuse Intrinsic Pontine Glioma (DIPG)? | [
"We found conservation of heterozygous K27M mutations in H3F3A (n = 4) or HIST1H3B (n = 3) across all primary, contiguous, and metastatic tumor sites in all DIPGs",
"found conservation of heterozygous k27m mutations in h3f3a (n = 4) or hist1h3b (n = 3) across all primary , contiguous , and metastatic tumor sites ... | [
"K27M in H3F3A",
"HIST1H3B"
] | [
"We found conservation of heterozygous K27M mutations in H3F3A (n = 4) or HIST1H3B (n = 3) across all primary, contiguous, and metastatic tumor sites in all DIPGs",
"ACVR1 (n = 2), PIK3CA (n = 2), FGFR1 (n = 2), and MET (n = 1) were also intra-tumorally conserved",
" TP53 aberrations (n = 3 patients) varied by ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26727948",
"http://www.ncbi.nlm.nih.gov/pubmed/27048880",
"http://www.ncbi.nlm.nih.gov/pubmed/22661320",
"http://www.ncbi.nlm.nih.gov/pubmed/25182241",
"http://www.ncbi.nlm.nih.gov/pubmed/27251074",
"http://www.ncbi.nlm.nih.gov/pubmed/24297113",
"http://www.ncbi.nlm.n... | [] | [] |
5883781b2305cd7e21000001 | yesno | Does Jarid2 play a role in early embryo development? | [
"Yes. Jarid2 coordinates Nanog expression and PCP/Wnt signaling required for efficient ESC differentiation and early embryo development."
] | [
"yes"
] | [
"Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development",
"Unlike other PRC2-deficient embryonic stem cells (ESCs), however, Jarid2-deficient ESCs show a severe differentiation block, altered colony morphology, and distinctive patterns of ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/20075857",
"http://www.ncbi.nlm.nih.gov/pubmed/26190104",
"http://www.ncbi.nlm.nih.gov/pubmed/17521633",
"http://www.ncbi.nlm.nih.gov/pubmed/24374312"
] | [
{
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"s": "http://linkedlifedata.com/resource/umls/id/C1416528",
"o": "JARID2"
},
{
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"s": "http://linkedlifedata.com/resource/#_5139323833330020",
"o": "JARID2"
},
{
"p": "http://... | [
"http://amigo.geneontology.org/amigo/term/GO:0009790",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D047108",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005314",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Ex... |
58bfe70e02b8c60953000019 | yesno | Is PUVA therapy indicated for eczema treatment? | [
"Yes, PUVA (psoralen plus UVA) therapy is effective for eczema treatment and has relatively few side effects."
] | [
"yes"
] | [
"With bath PUVA treatment, the best results were found in patients with hyperkeratotic eczema (17/22; 77% good clinical response) followed by patients with palmoplantar psoriasis (26/41; 63%) and patients with dyshidrotic eczema (8/16; 50%). ",
"Oral vs. bath PUVA using 8-methoxypsoralen for chronic palmoplantar ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/3903677",
"http://www.ncbi.nlm.nih.gov/pubmed/23420314",
"http://www.ncbi.nlm.nih.gov/pubmed/14699368",
"http://www.ncbi.nlm.nih.gov/pubmed/17254029",
"http://www.ncbi.nlm.nih.gov/pubmed/708596",
"http://www.ncbi.nlm.nih.gov/pubmed/10321515",
"http://www.ncbi.nlm.nih.... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/umls/id/C0034172",
"o": "PUVA Therapy"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0034172",
"o": "http://linkedlifedata.com/resourc... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004485",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011701"
] |
58837ba62305cd7e21000002 | summary | What is DECKO? | [
"DECKO (Double Excision CRISPR Knockout) is a dual CRISPR tool, which is cloned using a single starting oligonucleotide, thereby affording simplicity and scalability to CRISPR knockout studies of non-coding genomic elements, including long non-coding RNAs."
] | [] | [
"DECKO: Single-oligo, dual-CRISPR deletion of genomic elements including long non-coding RNAs",
"We present a dual CRISPR tool, DECKO, which is cloned using a single starting oligonucleotide, thereby affording simplicity and scalability to CRISPR knockout studies of non-coding genomic elements, including long non... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26493208"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D064113"
] |
58dfd83a6fddd3e83e000003 | list | List genes associated with hypolipidemia. | [
"PCSK9\nAPOB \nANGPTL3\nANGPTL4\nMTP"
] | [
"PCSK9",
"APOB",
"ANGPTL3",
"ANGPTL4",
"MTP"
] | [
" Conversely familial hypobetalipoproteinemia is caused by inactivation of the PCSK9 gene which increases the number of LDL receptors and decreases plasma cholesterol.",
"Mutations in the genes APOB, and ANGPTL3 and ANGPTL4 (that encode angiopoietin-like proteins which inhibit lipoprotein lipase activity) can fur... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22247256",
"http://www.ncbi.nlm.nih.gov/pubmed/26546829",
"http://www.ncbi.nlm.nih.gov/pubmed/24751931",
"http://www.ncbi.nlm.nih.gov/pubmed/22062970"
] | [] | [] |
58dfe6b56fddd3e83e000004 | factoid | What is the enzymatic activity of PARL? | [
"the mitochondrial protease presenilin-associated rhomboid-like (PARL). Rhomboids are a recently discovered family of widely distributed intramembrane serine proteases."
] | [
"PARL are serine proteases"
] | [
"Here we demonstrate that the mitochondrial protease presenilin-associated rhomboid-like (PARL) can affect the proteolytic processing of PINK1 and that normal PINK1 localization and stability requires PARL's catalytic activity. ",
"The mitochondrial rhomboid protease Parl governs apoptosis, morphology, metabolism... | [
"http://www.ncbi.nlm.nih.gov/pubmed/17938163",
"http://www.ncbi.nlm.nih.gov/pubmed/21415861",
"http://www.ncbi.nlm.nih.gov/pubmed/21355049",
"http://www.ncbi.nlm.nih.gov/pubmed/19859837"
] | [] | [] |
58ca906a02b8c6095300002e | yesno | Do brown fat cells produce heat? | [
"Yes, brown fat cells produce heat."
] | [
"yes"
] | [
"WAT and BAT are both involved in energy balance. WAT is mainly involved in the storage and mobilization of energy in the form of triglycerides, whereas BAT specializes in dissipating energy as heat during cold- or diet-induced thermogenesis.",
"Because brown adipose tissue (BAT) dissipates energy in the form of ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23834768",
"http://www.ncbi.nlm.nih.gov/pubmed/26910308",
"http://www.ncbi.nlm.nih.gov/pubmed/22796012",
"http://www.ncbi.nlm.nih.gov/pubmed/21196229",
"http://www.ncbi.nlm.nih.gov/pubmed/23818608",
"http://www.ncbi.nlm.nih.gov/pubmed/6148836",
"http://www.ncbi.nlm.ni... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/umls/id/C0018837",
"o": "Heat"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0018837",
"o": "http://linkedlifedata.com/resource/umls/l... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002477",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002001",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D052437",
"https://www.nlm.nih.gov/cgi/me... |
58d388958acda34529000006 | summary | What is a mimotope vaccine? | [
"A mimotope vaccine contains peptide mimics of specific antigen epitopes, which alter the antigen presentation and/or T cell activation to increase the expansion of tumor-specific T cells and are able to induce polyclonal antibodies response."
] | [] | [
"These data are proof of principle that by performing affinity selection on neutralizing antibodies, our VLP technology can identify peptide mimics of non-linear epitopes and that these mimotope based VLP vaccines provide protection against pathogens in relevant animal models.",
"A major hurdle in vaccine develop... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15634921",
"http://www.ncbi.nlm.nih.gov/pubmed/16634806",
"http://www.ncbi.nlm.nih.gov/pubmed/19344285",
"http://www.ncbi.nlm.nih.gov/pubmed/16814270",
"http://www.ncbi.nlm.nih.gov/pubmed/19846865",
"http://www.ncbi.nlm.nih.gov/pubmed/17597331",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/rxnorm/id/11094",
"o": "http://linkedlifedata.com/resource/rxnorm/label/354401"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/rxnorm/label/35440... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016233",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D064166",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014612"
] |
588f9b7eed9bbee70d000003 | summary | Describe clinical manifestation of the Mal de debarquement syndrome. | [
"Mal de debarquement syndrome (MdDS) is a disorder of chronic self-motion perception that occurs though entrainment to rhythmic background motion, such as from sea voyage, and involves the perception of low-frequency rocking that can last for months or years."
] | [] | [
"Mal de debarquement (MdD) is a subjective perception of self-motion after exposure to passive motion, in most cases sea travel, hence the name. Mal de debarquement occurs quite frequently in otherwise healthy individuals for a short period of time (several hours). However, in some people symptoms remain for a long... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25570942",
"http://www.ncbi.nlm.nih.gov/pubmed/25076935",
"http://www.ncbi.nlm.nih.gov/pubmed/26346344",
"http://www.ncbi.nlm.nih.gov/pubmed/23219828",
"http://www.ncbi.nlm.nih.gov/pubmed/25809585",
"http://www.ncbi.nlm.nih.gov/pubmed/26559820",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C1608983",
"o": "http://linkedlifedata.com/resource/umls/label/A18471215"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A1847... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013577",
"http://www.disease-ontology.org/api/metadata/DOID:225"
] |
58caf88c02b8c60953000031 | yesno | Is Melioidosis caused by the bacterium Burkholderia pseudomallei? | [
"Burkholderia pseudomallei is the causative agent of melioidosis"
] | [
"yes"
] | [
"Burkholderia pseudomallei, the causative agent of melioidosis,",
"What drives the occurrence of the melioidosis bacterium Burkholderia pseudomallei in domestic gardens?",
"Landscape changes influence the occurrence of the melioidosis bacterium Burkholderia pseudomallei in soil in northern Australia.",
"Out o... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24603493",
"http://www.ncbi.nlm.nih.gov/pubmed/26542622",
"http://www.ncbi.nlm.nih.gov/pubmed/25653950",
"http://www.ncbi.nlm.nih.gov/pubmed/19538822",
"http://www.ncbi.nlm.nih.gov/pubmed/22176696",
"http://www.ncbi.nlm.nih.gov/pubmed/17582188",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/umls/id/C0025229",
"o": "Melioidosis"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0025229",
"o": "http://linkedlifedata.com/resource... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019121",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016957",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008554"
] |
589a246a78275d0c4a000031 | summary | What is the mechanism of action of verubecestat? | [
"Verubecestat (MK-8931), a diaryl amide-substituted 3-imino-1,2,4-thiadiazinane 1,1-dioxide derivative, is a potent, selective, structurally unique BACE1 inhibitor that reduced plasma, cerebrospinal fluid (CSF), and brain concentrations of Aβ40, Aβ42, and sAPPβ (a direct product of BACE1 enzymatic activity)."
] | [] | [
"The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients.",
"We show that verubecestat (MK-8931) is a potent, selective, structurally unique BACE1 inhibitor that reduced plasma, cerebrospinal fluid (CSF), and brain concentrations of Aβ40, Aβ42, and sAP... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27933948",
"http://www.ncbi.nlm.nih.gov/pubmed/27023706",
"http://www.ncbi.nlm.nih.gov/pubmed/27678025",
"http://www.ncbi.nlm.nih.gov/pubmed/27807285",
"http://www.ncbi.nlm.nih.gov/pubmed/27934506"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D045504"
] |
58bac5e822d3005309000012 | summary | How are triple negative gliomas characterized? | [
"of these markers - 1p/19q deletions , mgmt methylation status , and mutations in the idh1 gene - are so potent that a new brain tumor subtype , the \"triple negative\" glioma (1p/19q intact , mgmt unmethylated , idh1 non-mutated) has entered common parlance . ",
"According to IDH, TP53, and 1p19q status, four ma... | [] | [
"According to IDH, TP53, and 1p19q status, four major subtypes of LGG are recorded: IDH+/p53-/1p19q-, IDH+/p53+/1p19q-, IDH+/p53-/1p19q+ and triple negative, this last subgroup having the worst prognosis.",
"Low-grade gliomas were accurately classified into four groups: group 1, IDH+/p53-/1p19q-; group 2, IDH+/p5... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23288644",
"http://www.ncbi.nlm.nih.gov/pubmed/22890969",
"http://www.ncbi.nlm.nih.gov/pubmed/26989023",
"http://www.ncbi.nlm.nih.gov/pubmed/23831947",
"http://www.ncbi.nlm.nih.gov/pubmed/26061753",
"http://www.ncbi.nlm.nih.gov/pubmed/21889777"
] | [] | [] |
58dc2c698acda3452900001f | summary | What is ectopia lentis? | [
"Ectopia Lentis is dislocation of the optic lens in the eye."
] | [] | [
"bilateral lens dislocation",
"Clinical manifestations include mental retardation, dislocation of the optic lens (ectopia lentis)",
"Ectopia lentis is a genetically heterogeneous condition that is characterized by the subluxation of the lens resulting from the disruption of the zonular fibers. "
] | [
"http://www.ncbi.nlm.nih.gov/pubmed/25797933",
"http://www.ncbi.nlm.nih.gov/pubmed/25939784",
"http://www.ncbi.nlm.nih.gov/pubmed/19200529"
] | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/umls/id/C0013581",
"o": "Ectopia lentis"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0013581",
"o": "http://linkedlifedata.com/resou... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004479"
] |
588482f5e56acf517600000a | yesno | Can glyburide reduce cerebral edema? | [
"Yes. Glyburide, a selective inhibitor of sulfonylurea receptor 1-transient receptor potential melastatin 4, is effective in preventing and attenuating cerebral edema."
] | [
"yes"
] | [
"Preclinical studies have shown that a continuous infusion of glyburide blocks edema formation and improves outcome. We hypothesize that treatment with RP-1127 (Glyburide for Injection) reduces formation of brain edema in patients after large anterior circulation infarction.",
"CONCLUSIONS: GAMES-RP was designed ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24193798",
"http://www.ncbi.nlm.nih.gov/pubmed/25422710",
"http://www.ncbi.nlm.nih.gov/pubmed/26463916",
"http://www.ncbi.nlm.nih.gov/pubmed/24072459",
"http://www.ncbi.nlm.nih.gov/pubmed/24552576",
"http://www.ncbi.nlm.nih.gov/pubmed/24671831",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/umls/id/C0017628",
"o": "glyburide"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0017628",
"o": "http://linkedlifedata.com/resource/u... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001929",
"http://www.biosemantics.org/jochem#4275786",
"http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:4275786",
"http://www.disease-ontology.org/api/metadata/DOID:4724",
"https://www.nlm.nih.gov/cgi/... |
58e2467a6fddd3e83e000012 | summary | What is the function of gasdermin D? | [
"The gasdermin-N domains of the gasdermin proteins can bind membrane lipids, phosphoinositides and cardiolipin to produce membrane-disrupting cytotoxicity."
] | [] | [
"gasdermin D (GSDMD) protein to trigger pyroptosis, a lytic form of cell death that is crucial for immune defences and diseases. ",
"Here we show that the gasdermin-N domains of the gasdermin proteins GSDMD, GSDMA3 and GSDMA can bind membrane lipids, phosphoinositides and cardiolipin, and exhibit membrane-disrupt... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26482951",
"http://www.ncbi.nlm.nih.gov/pubmed/27932073",
"http://www.ncbi.nlm.nih.gov/pubmed/27281216",
"http://www.ncbi.nlm.nih.gov/pubmed/26611636"
] | [
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C1539620",
"o": "http://linkedlifedata.com/resource/umls/label/A20719561"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A2071... | [
"http://www.uniprot.org/uniprot/GSDMD_MOUSE",
"http://www.uniprot.org/uniprot/GSDMD_HUMAN"
] |
587d016ed673c3eb14000002 | summary | What is TOPAZ1? | [
"TOPAZ1 is a novel germ cell-specific expressed gene conserved during evolution across vertebrates. Its PAZ-domain protein is abundantly expressed in the gonads during germ cell meiosis. The expression pattern of TOPAZ1, and its high degree of conservation, suggests that it may play an important role in germ cell d... | [] | [
"TOPAZ1, a germ cell specific factor, is essential for male meiotic progression",
"Topaz1 (Testis and Ovary-specific PAZ domain gene 1) is a germ cell specific gene highly conserved in vertebrates",
"Topaz1 is supposed to have a role during gametogenesis and may be involved in the piRNA pathway and contribute t... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26358182",
"http://www.ncbi.nlm.nih.gov/pubmed/22069478"
] | [] | [
"http://www.uniprot.org/uniprot/TOPZ1_BOVIN",
"http://www.uniprot.org/uniprot/TOPZ1_RAT",
"http://www.uniprot.org/uniprot/TOPZ1_MOUSE",
"http://www.uniprot.org/uniprot/TOPZ1_MACFA",
"http://www.uniprot.org/uniprot/TOPZ1_CALJA",
"http://www.uniprot.org/uniprot/TOPZ1_MACMU",
"http://www.uniprot.org/unipro... |
58c6665602b8c60953000024 | list | Which are the symptoms of glucose-6-phosphate dehydrogenase (G6PD) deficiency? | [
"Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is the most common red blood cell (RBC) enzyme disorder. The decrease as well as the absence of the enzyme increase RBC vulnerability to oxidative stress caused by exposure to certain medications or intake of fava beans. Among the most common symptoms ... | [
"acute hemolysis",
"chronic hemolysis",
"neonatal hyperbilirubinemia"
] | [
"Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is the most common red blood cell (RBC) enzyme disorder. The decrease as well as the absence of the enzyme increase RBC vulnerability to oxidative stress caused by exposure to certain medications or intake of fava beans. Among the most common clinical ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24865682",
"http://www.ncbi.nlm.nih.gov/pubmed/24372186",
"http://www.ncbi.nlm.nih.gov/pubmed/11233775",
"http://www.ncbi.nlm.nih.gov/pubmed/20684792",
"http://www.ncbi.nlm.nih.gov/pubmed/21336800",
"http://www.ncbi.nlm.nih.gov/pubmed/16450734",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2004/02/skos/core#exactMatch",
"s": "http://purl.uniprot.org/uniprot/P11413",
"o": "http://purl.uniprot.org/uniprot/P11413"
},
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/umls/id/C0017757",
"o": "G6PD"
},
{
... | [
"http://www.uniprot.org/uniprot/G6PD_BUCAI",
"http://www.disease-ontology.org/api/metadata/DOID:2862",
"http://www.uniprot.org/uniprot/G6PD_CERCA",
"http://www.uniprot.org/uniprot/G6PD_CRIGR",
"http://www.uniprot.org/uniprot/G6PD_ECOLI",
"http://www.uniprot.org/uniprot/G6PD_EMENI",
"http://www.uniprot.o... |
58dfec676fddd3e83e000006 | yesno | Has the gorilla genome been determined? | [
"Yes, the gorilla genome has been sequenced."
] | [
"yes"
] | [
"Starting with human, chimpanzee, gorilla, and orangutan genomes, our software generated an exhaustive data set of 292 ALs (∼1 kb each) in ∼3 h. ",
"We generated a high-quality assembly of the gorilla genome using single-molecule, real-time sequence technology and a string graph de novo assembly algorithm",
"He... | [
"http://www.ncbi.nlm.nih.gov/pubmed/11592477",
"http://www.ncbi.nlm.nih.gov/pubmed/27034376",
"http://www.ncbi.nlm.nih.gov/pubmed/22398555",
"http://www.ncbi.nlm.nih.gov/pubmed/27435933"
] | [] | [] |
58848ea5e56acf517600000e | yesno | Is vemurafenib used for thyroid cancer? | [
"Yes. Vemurafenib, a selective BRAF inhibitor, appears to have promising clinical activity in patients with papillary thyroid cancer (PTC) harboring the BRAF(V600E) mutation."
] | [
"yes"
] | [
"Vemurafenib in patients with BRAF(V600E)-positive metastatic or unresectable papillary thyroid cancer refractory to radioactive iodine: a non-randomised, multicentre, open-label, phase 2 trial.",
"Vemurafenib, an oncogenic BRAF kinase inhibitor approved for BRAF-positive melanoma, showed clinical benefit in thre... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27460442",
"http://www.ncbi.nlm.nih.gov/pubmed/27554612",
"http://www.ncbi.nlm.nih.gov/pubmed/27754804",
"http://www.ncbi.nlm.nih.gov/pubmed/24987354",
"http://www.ncbi.nlm.nih.gov/pubmed/23489023",
"http://www.ncbi.nlm.nih.gov/pubmed/26751190",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/rxnorm/id/1147220",
"o": "VEMURAFENIB"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C3192263",
"o": "http://linkedlifedata.com/resourc... | [
"http://www.disease-ontology.org/api/metadata/DOID:3963",
"http://www.disease-ontology.org/api/metadata/DOID:1781",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013964"
] |
58e11bf76fddd3e83e00000c | yesno | Are mutations in the C9orf72 gene associated with macular degeneration? | [
"Amyotrophic lateral sclerosis (ALS) is characterized by motor neurone loss resulting in muscle weakness, spasticity and ultimately death. 5-10% are caused by inherited mutations, most commonly C9ORF72, SOD1, TARDBP and FUS."
] | [
"no"
] | [
"Over the years, however, growing evidence from clinical, pathological and genetic findings has suggested that ALS and FTD belong to the same clinic-pathological spectrum disorder. This concept has been further supported by the identification of the most common genetic cause for both diseases, an aberrantly expande... | [
"http://www.ncbi.nlm.nih.gov/pubmed/26303227",
"http://www.ncbi.nlm.nih.gov/pubmed/24521566",
"http://www.ncbi.nlm.nih.gov/pubmed/27632209",
"http://www.ncbi.nlm.nih.gov/pubmed/22892647",
"http://www.ncbi.nlm.nih.gov/pubmed/22300873",
"http://www.ncbi.nlm.nih.gov/pubmed/22366791",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/umls/id/C1428691",
"o": "C9orf72"
},
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"http://www.disease-ontology.org/api/metadata/DOID:4448",
"http://www.disease-ontology.org/api/metadata/DOID:10871",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D057135",
"http... |
58dff3f06fddd3e83e000007 | summary | What is the Genome 10K Project? | [
"The Genome 10K Project was established in 2009 by a consortium of biologists and genome scientists determined to facilitate the sequencing and analysis of the complete genomes of 10,000 vertebrate species."
] | [] | [
"The Genome 10K Project was established in 2009 by a consortium of biologists and genome scientists determined to facilitate the sequencing and analysis of the complete genomes of 10,000 vertebrate species.",
"The Genome 10K project aims to sequence the genomes of 10,000 vertebrates, representing approximately on... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25689317",
"http://www.ncbi.nlm.nih.gov/pubmed/22897955"
] | [] | [] |
58e75d483e8b6dc87c000005 | factoid | Which gene controls the expression of GATA-1 isoforms? | [
"In this study, we report a transcriptional network in which PU.1 positively regulates GATA-1 expression in mast cell development. This isoform contains an alternatively spliced first exon (IB) that is distinct from the first exon (IE) incorporated in the major erythroid mRNA transcript.",
"A transcriptional net... | [
"PU.1"
] | [
"Mutations in exon 2 interfere with the synthesis of the full-length isoform of GATA-1 and lead to the production of a shortened isoform, GATA-1s.",
"In this study, we report a transcriptional network in which PU.1 positively regulates GATA-1 expression in mast cell development. ",
"This isoform contains an alt... | [
"http://www.ncbi.nlm.nih.gov/pubmed/12202480",
"http://www.ncbi.nlm.nih.gov/pubmed/24453067",
"http://www.ncbi.nlm.nih.gov/pubmed/20304827"
] | [] | [] |
588fd7cded9bbee70d000009 | summary | What is MIRA-seq? | [
"MIRA-seq is a reliable, genome-scale DNA methylation analysis platform for scoring DNA methylation differences at CpG-rich genomic regions. The method is not limited by primer or probe design and is cost effective."
] | [] | [
"MIRA-seq for DNA methylation analysis of CpG islands.",
"MIRA-seq is a reliable, genome-scale DNA methylation analysis platform for scoring DNA methylation differences at CpG-rich genomic regions. The method is not limited by primer or probe design and is cost effective.",
"Using MIRA-seq, we have characterize... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25881900",
"http://www.ncbi.nlm.nih.gov/pubmed/26384656",
"http://www.ncbi.nlm.nih.gov/pubmed/27009155",
"http://www.ncbi.nlm.nih.gov/pubmed/25623529"
] | [] | [
"http://amigo.geneontology.org/amigo/term/GO:1905642",
"http://amigo.geneontology.org/amigo/term/GO:0044029",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019175",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018899",
"http://amig... |
58af14ae717cd3f655000001 | summary | How does Ssu72 mediate gene looping? | [
"Investigation of chromosome folding in mutants confirms roles for RSC, \"gene looping\" factor Ssu72, Mediator, H3K56 acetyltransferase Rtt109, and the N-terminal tail of H4 in folding of the yeast genome. The essential N terminus of the Pta1 scaffold protein is required for snoRNA transcription termination and Ss... | [] | [
"Investigation of chromosome folding in mutants confirms roles for RSC, \"gene looping\" factor Ssu72, Mediator, H3K56 acetyltransferase Rtt109, and the N-terminal tail of H4 in folding of the yeast genome.",
"Furthermore, different regions of Pta1 interact with the CPF subunits Ssu72, Pti1, and Ysh1, supporting ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24945319",
"http://www.ncbi.nlm.nih.gov/pubmed/19188448",
"http://www.ncbi.nlm.nih.gov/pubmed/17803944",
"http://www.ncbi.nlm.nih.gov/pubmed/16319194",
"http://www.ncbi.nlm.nih.gov/pubmed/26119342",
"http://www.ncbi.nlm.nih.gov/pubmed/12704082"
] | [] | [] |
58e26ede6fddd3e83e000015 | yesno | Is the number of described human nuclear mutations less than 50000? | [
"No, The number of known mutations in human nuclear genes, underlying or associated with human inherited disease, has now exceeded 100,000 in more than 3700 different genes (Human Gene Mutation Database)."
] | [
"no"
] | [
"The number of known mutations in human nuclear genes, underlying or associated with human inherited disease, has now exceeded 100,000 in more than 3700 different genes (Human Gene Mutation Database).",
"The Human Gene Mutation Database (HGMD®) is a comprehensive collection of germline mutations in nuclear genes ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22948725",
"http://www.ncbi.nlm.nih.gov/pubmed/20569258",
"http://www.ncbi.nlm.nih.gov/pubmed/24077912"
] | [] | [] |
58d131218acda34529000005 | summary | What is the role of peptide aptamers? | [
"Peptide aptamers are artificial short peptides which are able to specifically bind to defined functional domains, track, and inhibit a given target molecule with high affinity, even molecules with poor immunogenicity or high toxicity. They represent a remarkable alternative to antibodies in many different applicat... | [] | [
"Peptide aptamers: The versatile role of specific protein function inhibitors in plant biotechnology.",
" These artificial short peptides are able to specifically bind, track, and inhibit a given target molecule with high affinity, even molecules with poor immunogenicity or high toxicity, and represent a remarkab... | [
"http://www.ncbi.nlm.nih.gov/pubmed/21224349",
"http://www.ncbi.nlm.nih.gov/pubmed/22949372",
"http://www.ncbi.nlm.nih.gov/pubmed/25966787",
"http://www.ncbi.nlm.nih.gov/pubmed/21838684",
"http://www.ncbi.nlm.nih.gov/pubmed/25238402",
"http://www.ncbi.nlm.nih.gov/pubmed/18186614",
"http://www.ncbi.nlm.n... | [
{
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"s": "http://linkedlifedata.com/resource/rxnorm/id/595798",
"o": "http://linkedlifedata.com/resource/rxnorm/label/3218865"
},
{
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"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D052158",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012380",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010455"
] |
58d8e9bd8acda3452900000b | list | Which are the clinical symptoms of left ventricular noncompaction? | [
"The clinical symptoms of left ventricular noncompaction are:\n1) heart failure, \n2) systemic thromboembolic events, \n3) ventricular arrhythmias and\n4) sudden cardiac death."
] | [
"heart failure",
"systemic thromboembolic events",
"systemic thromboembolism",
"ventricular arrhythmias",
"sudden cardiac death"
] | [
"Perioperative management of the patient with LVNC might be challenging due to the clinical symptoms of heart failure, systemic thromboembolic events, and fatal left ventricular arrhythmias.",
"Left ventricular noncompaction cardiomyopathy is a rare type of congenital cardiomyopathy characterized by prematurely a... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27274374",
"http://www.ncbi.nlm.nih.gov/pubmed/15458689",
"http://www.ncbi.nlm.nih.gov/pubmed/11858389",
"http://www.ncbi.nlm.nih.gov/pubmed/19218740",
"http://www.ncbi.nlm.nih.gov/pubmed/24231893",
"http://www.ncbi.nlm.nih.gov/pubmed/20347493",
"http://www.ncbi.nlm.n... | [
{
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"s": "http://linkedlifedata.com/resource/umls/id/C1457887",
"o": "Symptoms"
},
{
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"s": "http://linkedlifedata.com/resource/umls/id/C1457887",
"o": "http://linkedlifedata.com/resource/um... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016277",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018754",
"http://www.disease-ontology.org/api/metadata/DOID:0060480",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=F... |
58cdbbd102b8c60953000045 | summary | What is the Glasgow Coma score? | [
"Glasgow coma sore is used to determine injury severity on admission to a hospital emergency department or by the duration of unconsciousness."
] | [] | [
" Injury severity was determined by the Glasgow Coma Scale (GCS) score on admission or by the duration of unconsciousness",
"Severity analysis was based on the Glasgow Coma Scale and Injury Severity Scor",
"The strongest correlations were found between the Glasgow coma score and quality of life (r = 0.236, P = ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25834958",
"http://www.ncbi.nlm.nih.gov/pubmed/26295284",
"http://www.ncbi.nlm.nih.gov/pubmed/23022643",
"http://www.ncbi.nlm.nih.gov/pubmed/11332457"
] | [] | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015600"
] |
5880b073c872c95565000003 | factoid | Andexanet Alfa is an antidote of which clotting factor inhibitors? | [
"Andexanet alfa is a specific reversal agent for Factor Xa inhibitors.",
"Andexanet alfa is a class-specific antidote targeted to reverse the oral direct factor Xa inhibitors as well as the indirect inhibitor, enoxaparin. Idarucizumab and andexanet alfa are NOAC-specific reversal agents designed to reverse dabiga... | [
"Factor Xa",
"Xa"
] | [
"Andexanet alfa is a class-specific antidote targeted to reverse the oral direct factor Xa inhibitors as well as the indirect inhibitor, enoxaparin.",
"Idarucizumab and andexanet alfa are NOAC-specific reversal agents designed to reverse dabigatran and factor Xa inhibitors accordingly.",
"Andexanet alfa for the... | [
"http://www.ncbi.nlm.nih.gov/pubmed/27147456",
"http://www.ncbi.nlm.nih.gov/pubmed/26449414",
"http://www.ncbi.nlm.nih.gov/pubmed/27082776",
"http://www.ncbi.nlm.nih.gov/pubmed/26559317",
"http://www.ncbi.nlm.nih.gov/pubmed/27575436",
"http://www.ncbi.nlm.nih.gov/pubmed/25516695",
"http://www.ncbi.nlm.n... | [
{
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"s": "http://linkedlifedata.com/resource/umls/id/C0003295",
"o": "antidote"
},
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"s": "http://linkedlifedata.com/resource/umls/id/C0003295",
"o": "http://linkedlifedata.com/resource/um... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000925",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000931",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019774"
] |
58da111c8acda34529000010 | factoid | Which is the main cause of the Patau syndrome? | [
"Patau syndrome is caused by trisomy 13."
] | [
"Trisome 13"
] | [
"Trisomy 13, or Patau syndrome is a rare chromosomal disorder characterized by a triad of cleft lip and palate, postaxial polydactyly and microcephaly.",
"Mosaic trisomy 13 is very rare, it occurs in only 5% of all patients with trisomy 13 phenotype.",
"Among full autosomal trisomies, only trisomies of chromoso... | [
"http://www.ncbi.nlm.nih.gov/pubmed/11885075",
"http://www.ncbi.nlm.nih.gov/pubmed/23613355",
"http://www.ncbi.nlm.nih.gov/pubmed/17603803",
"http://www.ncbi.nlm.nih.gov/pubmed/14506431",
"http://www.ncbi.nlm.nih.gov/pubmed/6458983",
"http://www.ncbi.nlm.nih.gov/pubmed/18467377",
"http://www.ncbi.nlm.ni... | [
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0152095",
"o": "http://linkedlifedata.com/resource/umls/label/A18670259"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#literalForm",
"s": "http://linkedlifedata.com/resource/umls/label/A1867... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002882",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013577",
"http://www.disease-ontology.org/api/metadata/DOID:11665"
] |
58af1cb3717cd3f655000003 | factoid | Which is the main abnormality that arises with Sox9 locus duplication? | [
"The 46,XX testicular disorder of sex development (DSD), also known as 46,XX male syndrome, is a rare form of DSD and clinical phenotype shows complete sex reversal from female to male. A complex network of genes determines sex in mammals. Differentiation of testicular tissue in 46,XX individuals is seen either in ... | [
"Autosomal XX sex reversal"
] | [
"Autosomal XX sex reversal caused by duplication of SOX9",
"Mutations of SOX9 leading to haploinsufficiency can cause campomelic dysplasia and XY sex reversal",
"We report here evidence supporting that SOX9 duplication can cause XX sex reversal",
"Fluorescent in situ hybridization (FISH) with a BAC clone cont... | [
"http://www.ncbi.nlm.nih.gov/pubmed/10588843",
"http://www.ncbi.nlm.nih.gov/pubmed/18391513",
"http://www.ncbi.nlm.nih.gov/pubmed/22678921",
"http://www.ncbi.nlm.nih.gov/pubmed/25010117",
"http://www.ncbi.nlm.nih.gov/pubmed/24040047",
"http://www.ncbi.nlm.nih.gov/pubmed/25077096",
"http://www.ncbi.nlm.n... | [] | [] |
58df779d6fddd3e83e000001 | yesno | Is Musclin a secretory peptide? | [
"Yes, musclin has been described as a muscle-derived secretory peptide."
] | [
"yes"
] | [
"Musclin is a novel skeletal muscle-derived secretory factor,",
"Musclin has been described as a muscle-derived secretory peptide, responsive to insulin in vivo, and inducing insulin resistance in vitro.",
"Musclin is a type of muscle-secreted cytokine and its increased gene expression induces insulin resistanc... | [
"http://www.ncbi.nlm.nih.gov/pubmed/19244276",
"http://www.ncbi.nlm.nih.gov/pubmed/26449458",
"http://www.ncbi.nlm.nih.gov/pubmed/17189616",
"http://www.ncbi.nlm.nih.gov/pubmed/24734231",
"http://www.ncbi.nlm.nih.gov/pubmed/23940802"
] | [] | [] |
58dd0dde8acda34529000027 | factoid | What tissue is commonly affected in Marfan's syndrome | [
"Marfan syndrome (MS) is a connective tissue disorder that affects thousands of adolescents ",
"Marfan syndrome (MS) is a connective tissue disorder that affects thousands of adolescents",
"Marfan syndrome (MS) is a connective tissue disorder that affects thousands of adolescents. ",
"Marfan syndrome (MS) is ... | [
"connective tissue"
] | [
"Marfan syndrome (MS) is a connective tissue disorder that affects thousands of adolescents ",
"Fibrillin-1 mutations have also been found in several other related connective tissue disorders, such as severe neonatal Marfan syndrome, dominant ectopia lentis, familial ascending aortic aneurysm, isolated skeletal f... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23304566",
"http://www.ncbi.nlm.nih.gov/pubmed/26494287",
"http://www.ncbi.nlm.nih.gov/pubmed/21723458",
"http://www.ncbi.nlm.nih.gov/pubmed/21308160",
"http://www.ncbi.nlm.nih.gov/pubmed/17620463",
"http://www.ncbi.nlm.nih.gov/pubmed/26272787",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/umls/id/C0024796",
"o": "Marfan Syndrome"
},
{
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/resource/umls/id/C0024796",
"o": "http://linkedlifedata.com/reso... | [
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008382",
"http://www.disease-ontology.org/api/metadata/DOID:14323"
] |
58853922e56acf5176000016 | factoid | To which disease does the loss of CD28 expression by liver-infiltrating T cells contribute? | [
"Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis.",
"Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis. ",
"loss of cd28 expression by liver-infiltrating t cells contributes to p... | [
"Primary sclerosing cholangitis"
] | [
"Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis.",
"Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis",
"Loss of CD28 expression by liver-infiltrating T cells contributes to pat... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24726754"
] | [] | [
"http://www.uniprot.org/uniprot/CD28_RABIT",
"http://www.uniprot.org/uniprot/CD28_RAT",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008107",
"http://www.uniprot.org/uniprot/CD28_HUMAN",
"http://www.uniprot.org/uniprot/CD28_CHICK",
"http://www.uniprot.org/uniprot/CD2... |
58e11b9b6fddd3e83e00000b | yesno | Are cutaneous porphyrias inherited with a recessive pattern? | [
"No, cutaneous porphyrias are inherited in a dominant (not recessive) pattern."
] | [
"no"
] | [
"Five of the porphyrias are low-penetrance autosomal dominant conditions in which clinical expression results from additional factors that act by increasing demand for haem or by causing an additional decrease in enzyme activity or by a combination of these effects",
"Molecular mechanisms of dominant expression i... | [
"http://www.ncbi.nlm.nih.gov/pubmed/15868463",
"http://www.ncbi.nlm.nih.gov/pubmed/11202049",
"http://www.ncbi.nlm.nih.gov/pubmed/12859407"
] | [] | [] |
5880e417713cbdfd3d000001 | factoid | Which disease is treated with ZMapp? | [
"ZMapp is a combination of antibodies for treatment of Ebola virus disease."
] | [
"Ebola virus disease"
] | [
"This includes agents belonging to various therapeutic classes, namely direct antiviral agents (favipiravir and BCX4430), a combination of antibodies (ZMapp), type I interferons, RNA interference-based drugs (TKM-Ebola and AVI-7537), and anticoagulant drugs (rNAPc2). ",
"During the latest outbreak of Ebola virus ... | [
"http://www.ncbi.nlm.nih.gov/pubmed/25694097",
"http://www.ncbi.nlm.nih.gov/pubmed/25171469",
"http://www.ncbi.nlm.nih.gov/pubmed/27274814",
"http://www.ncbi.nlm.nih.gov/pubmed/26311869",
"http://www.ncbi.nlm.nih.gov/pubmed/25404321",
"http://www.ncbi.nlm.nih.gov/pubmed/26962157",
"http://www.ncbi.nlm.n... | [
{
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"o": "http://linkedlifedata.com/resource/umls/label/A0049608"
},
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"s": "http://linkedlifedata.com/resource/umls/label/A00496... | [
"http://www.disease-ontology.org/api/metadata/DOID:4",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004194",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=diseases_category"
] |
58d8d0cc8acda34529000008 | yesno | Can methylenetetrahydrofolate reductase (MTHFR) gene mutations cause homocystinuria? | [
"Yes, several methylenetetrahydrofolate reductase (MTHFR) gene mutations can cause homocystinuria and hyperhomocysteinemia."
] | [
"yes"
] | [
"Methylenetetrahydrofolate reductase (MTHFR) deficiency is a rare autosomal recessive disorder. ",
"Several mutations seen in methylenetetrahydrofolate reductase (MTHFR) give rise to the formation of hyperhomocysteinemia and homocystinuria, a considerable risk factor for cardiovascular and cerebrovascular disorde... | [
"http://www.ncbi.nlm.nih.gov/pubmed/16629766",
"http://www.ncbi.nlm.nih.gov/pubmed/27130656",
"http://www.ncbi.nlm.nih.gov/pubmed/10980581",
"http://www.ncbi.nlm.nih.gov/pubmed/23095199",
"http://www.ncbi.nlm.nih.gov/pubmed/10923034",
"http://www.ncbi.nlm.nih.gov/pubmed/21626167",
"http://www.ncbi.nlm.n... | [
{
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/umls/id/C0066357",
"o": "MTHFR"
},
{
"p": "http://www.w3.org/2004/02/skos/core#prefLabel",
"s": "http://linkedlifedata.com/resource/#_5034323839380027",
"o": "MTHFR"
},
{
"p": "http://ww... | [
"http://www.uniprot.org/uniprot/MTHR_MOUSE",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006712",
"http://www.uniprot.org/uniprot/MTHR_BOVIN",
"http://www.disease-ontology.org/api/metadata/DOID:9263",
"http://www.uniprot.org/uniprot/MTHR_MACFA",
"https://www.nlm.nih... |
58af16ea717cd3f655000002 | factoid | What happens to H2AX upon DNA bouble strand breaks? | [
" Phosphorylated H2AX (γH2AX) is rapidly concentrated in chromatin domains around DNA double-strand breaks (DSBs) after the action of ionizing radiation or chemical agents and at stalled replication forks during replication stress The nuclear foci of phosphorylated histone H2AX (γH2AX) are frequently used as a mark... | [
"it is rapidly concentrated"
] | [
"Histone H2AX phosphorylation as a measure of DNA double-strand breaks and a marker of environmental stress and disease activity in lupus",
"DSBs were quantified in peripheral blood mononuclear cell subsets from patients with SLE, healthy controls, and patients with rheumatoid arthritis (RA) by measuring phosphor... | [
"http://www.ncbi.nlm.nih.gov/pubmed/24682951",
"http://www.ncbi.nlm.nih.gov/pubmed/27158526",
"http://www.ncbi.nlm.nih.gov/pubmed/22704343",
"http://www.ncbi.nlm.nih.gov/pubmed/21511815"
] | [] | [] |
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